Investigators provided in vivo evidence that Runx2 played a crucial role in tooth root development and in regulating the differentiation of root progenitor cells.
[Journal of Bone and Mineral Research]
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Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity, mineralization ability, and gene expression of osteogenic makers.
[International Journal of Oral Science]
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Cui, Y., Xie, J., Fu, Y., Li, C., Zheng, L., Huang, D., Zhou, C., Sun, J., & Zhou, X. (2020). Berberine mediates root remodeling in an immature tooth with apical periodontitis by regulating stem cells from apical papilla differentiation. International Journal of Oral Science, 12(1), 1–10. https://doi.org/10.1038/s41368-020-0085-7 Cite
Scientists found that LPS, flagellin, dsDNA, nigericin, or LPS combined with nigericin could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells.
[Cell Death & Disease]
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Zhang, C., Zhao, C., Chen, X., Tao, R., Wang, S., Meng, G., Liu, X., Shao, C., & Su, X. (2020). Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages. Cell Death & Disease, 11(6), 1–13. https://doi.org/10.1038/s41419-020-2664-0 Cite
Functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity.
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Ambrosi, T. H., Goodnough, L. H., Steininger, H. M., Hoover, M. Y., Kim, E., Koepke, L. S., Marecic, O., Zhao, L., Seita, J., Bishop, J. A., Gardner, M. J., & Chan, C. K. F. (n.d.). Geriatric fragility fractures are associated with a human skeletal stem cell defect. Aging Cell, n/a(n/a), e13164. https://doi.org/10.1111/acel.13164 Cite
The authors investigated whether damage-induced transforming growth factor β signaling impaired the expression and function of T-cell factor 4, using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors.
[Journal of Cell Science]
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The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discusses the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
Researchers report that fibronectin 1 promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts.
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Yang, C., Wang, C., Zhou, J., Liang, Q., He, F., Li, F., Li, Y., Chen, J., Zhang, F., Han, C., Liu, J., Li, K., & Tang, Y. (2020). Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction. Laboratory Investigation, 1–9. https://doi.org/10.1038/s41374-020-0451-2 Cite
While loss of Piezo2 in chondrogenic or osteogenic lineages did not lead to human-like skeletal abnormalities, its loss in proprioceptive neurons led to spine malalignment and hip dysplasia.
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Assaraf, E., Blecher, R., Heinemann-Yerushalmi, L., Krief, S., Carmel Vinestock, R., Biton, I. E., Brumfeld, V., Rotkopf, R., Avisar, E., Agar, G., & Zelzer, E. (2020). Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity. Nature Communications, 11(1), 3168. https://doi.org/10.1038/s41467-020-16971-6 Cite
Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
[International Journal of Molecular Sciences]
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Samper Agrelo, I., Schira-Heinen, J., Beyer, F., Groh, J., Bütermann, C., Estrada, V., Poschmann, G., Bribian, A., Jadasz, J. J., Lopez-Mascaraque, L., Kremer, D., Martini, R., Müller, H. W., Hartung, H. P., Adjaye, J., Stühler, K., & Küry, P. (2020). Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. International Journal of Molecular Sciences, 21(12), 4350. https://doi.org/10.3390/ijms21124350 Cite
Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
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Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
[Journal of Autoimmunity]
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