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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Hope Biosciences Secures FDA RMAT Designation for Stem Cell Therapy in Relapsing-Remitting Multiple Sclerosis
[Hope Biosciences (Business Wire)] Hope Biosciences announced that the US FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation for Hope Biosciences’ adipose-derived mesenchymal stem cells for the treatment of patients living with relapsing-remitting multiple sclerosis.
Interpenetrating Polymer Network Hydrogel Composition Alters Encapsulated MSC Spreading and In Vivo Degradation Behavior
[ACS Biomaterials Science & Engineering] Researchers mimicked the ECM by providing a more supportive environment for encapsulated cells, allowing them to adhere, spread, and proliferate, which may be useful in various MSC-based tissue engineering and regenerative medicine applications.
Human Umbilical Cord Mesenchymal Stem Cells Inhibit the Progression of Osteoarthritis by Suppressing NLRP3-Mediated Synovial Inflammation in the Early Stages of the Disease
[Stem Cells International] Researchers suggested that human umbilical cord mesenchymal stem cells exert therapeutic effects on osteoarthritis (OS), at least in part, through inhibiting nod-like receptor heat protein domain protein 3 (NLRP3)-mediated synovial inflammation in the early stage of OA.
Borate-Ion-Stimulated Macrophages Promote Osteogenic Differentiation of Mesenchymal Stem Cells
[Advanced Healthcare Materials] The effects of borate-ion-stimulated mouse macrophages on the osteogenic differentiation of mouse bone marrow–derived MSCs were investigated.
Molecular Signature and Regulatory Network of Human Umbilical Cord Mesenchymal Stromal Cells As a Niche for Hematopoietic Stem Cells and Progenitors
[Stem Cells] Cocultures of umbilical cord MSCs and umbilical cord blood CD34+ (UCB-CD34+) cells were established. Immunophenotype, cell proliferation, and hematopoietic function of UCB-CD34+ cells were evaluated on days 0 to 7.
Hanging Drop Culture Reprograms Mesenchymal Stem Cell Transcriptome to Enhance Cell Delivery Efficiency via Attenuated Pulmonary Entrapment
[Drug Delivery and Translational Research] Scientists utilized a hanging drop method to generate 3D spheroid-derived MSCs and compared them to conventionally 2D-cultured MSCs. The results showed that 3D MSCs exhibited distinct phenotypic features than 2D-cultured MSCs and expressed different transcriptional responses, as found from RNA-Seq analysis.
Cyclic Stretch Bioreactor Enhances Tenogenic Differentiation of MSCs in Biomimicked PCL-tdECM Membranes through Dynamic Mechanical Loading
[ACS Biomaterials Science & Engineering] Investigators demonstrated a tissue engineering approach combining dynamic mechanical cues from a bioreactor and biochemical cues from goat tendon decellularized extracellular matrix (tdECM) to induce tenogenesis in umbilical cord MSCs.
Mesenchymal Stem Cells-Derived Mir-143-3p Attenuate Acute Kidney Injury by Suppressing TAK1-Driven Necroptosis
[Biochemical and Biophysical Research Communications] Scientists demonstrated that human umbilical cord MSCs alleviated cisplatin-induced AKI by suppressing necroptosis through targeting transforming growth factor-β-activated kinase 1 (TAK1).
Engineering a Cell-Free Bone Regeneration Platform Using Osteogenically Primed MSC-EVs and nHAp-Enriched IPN Hydrogels
[Regenerative Medicine] Investigators enhanced the osteoinductive potential of MSC-derived extracellular vesicles by integrating them into a nano-hydroxyapatite (nHAp)-enriched hydrogel scaffold for bone regeneration applications.
Periadventitial Delivery of Mesenchymal Stem Cells Improves Vascular Remodeling and Maturation in Arteriovenous Fistulas
[Science Translational Medicine] A Phase I randomized trial in patients undergoing upper extremity arteriovenous fistula (AVF) placement was performed to evaluate the safety and efficacy of autologous adipose–derived MSCs in improving AVF function.
Chromosomal Abnormalities of Mesenchymal Stromal Cells in Hematological Malignancies
[Oncogene] Chromasomal instability can lead to abnormal gene expression, cellular senescence, and inflammation, altering MSCs.
The Interrelationship Between Interleukin-17Â a and the Immunomodulation of Mesenchymal Stromal Cells
[Stem Cell Research & Therapy] The authors elucidate the complex relationship between IL-17 A and MSCs in immune regulation, and to provide a theoretical foundation and new insights for the development of immunotherapy strategies based on MSCs in the future.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
