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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Stepwise Differentiation of Airway Epithelial Cells from Human Tonsil-Derived Mesenchymal Stem Cells
[Stem Cell Research & Therapy] Investigators developed an alternative approach to respiratory epithelial regeneration using human tonsil-derived MSCs to induce epithelial cell differentiation through a stepwise process.
Gelated Microvesicle-Mediated Delivery of Mesenchymal Stem Cell Mitochondria for the Treatment of Myocardial Infarction
[Proceedings of the National Academy of Sciences of the United States of America] Scientists introduced a gelated microvesicle–based mitochondria delivery system designed to deliver active MSC mitochondria to injured cells, rescuing mitochondrial dysfunction and thereby treating myocardial infarction.
A Review on Mesenchymal Stem Cells and Their Secretome in Hepatocellular Carcinogenesis and Its Related Signaling Pathways: Recent Update
[Discover Oncology] The authors summarize the role of MSCs in hepatocellular carcinoma (HCC), highlighting its involvement in different cell signaling pathways, including NF-κB, Wnt/β-catenin, Notch1, Stat3, and TGF-β, which play a significant role in HCC.
Divide-and-Conquer Strategy with Engineered Ossification Center Organoids for Rapid Bone Healing through Developmental Cell Recruitment
[Nature Communications] Researchers engineered an ossification center-like organoid that consists of an inner-core bone morphogenetic and neurotrophic spheroid generated via MSCs-loaded 3D printing, alongside the interstitially distributed outer-shell proangigenic neurotrophic phase.
Therapeutic Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on ER Stress in a Murine Model of Metabolic Dysfunction-Associated Steatohepatitis: An In Vivo and In...
[Stem Cell Research & Therapy] Scientists investigated the therapeutic mechanism of adipose tissue-derived stem cells in metabolic dysfunction-associated steatohepatitis, focusing on their modulation of endoplasmic reticulum stress in hepatocytes.
Single-Cell Transcriptome Atlas Reveals Mitophagy Dynamics in Acute Chemical Injury Model and the Role of MSCs Transplantation
[Stem Cell Research & Therapy] The authors explored the distinct mitophagy states in hepatocytes and macrophages during MSC therapy. MSCs are capable of alleviating disease progression by modulating the distinct mitophagy states of cells.
Novel Sponge Formulation of Mesenchymal Stem Cell Secretome and Hyaluronic Acid: A Safe and Effective Topical Therapy for Psoriasis Vulgaris
[Stem Cell Research & Therapy] Researchers explored a novel therapeutic approach using the secretome from Wharton Jelly-derived MSCs, biologically stabilized and enhanced with hyaluronic acid, its presentation is an easy-to-apply topical sponge.
PIEZO1 Activity Promotes Stemness in Mesenchymal Stem Cells under Shear Stress and Enhances Protection of Leukemia Cells
[Scientific Reports] The authors determined the cellular effects of piezo-type mechanosensitive ion channel component 1 (PIEZO1), a mechanically activated ion channel protein on proliferation, differentiation, migration, and leukemia support of human bone marrow-derived MSCs.
Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long-Term Neuroprotection After Traumatic Brain Injury in Mice
[Advanced Science] Researchers demonstrated the neuroprotective effects of MSC-secretome treatment in traumatic brain injury and highlight prostaglandins and kynurenine as key mediators of this response.
A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis
[Advanced Science] The authors revealed that hematopoietic stem cells (HSCs) and MSCs within skeletal stem cells interact via a feedback loop: HSCs undergo premature senescence, leading to depletion of HSCs and secondary senescence of MSCs.
Integrative Analysis of Bulk and Single-Cell Gene Expression Profiles to Identify Bone Marrow Mesenchymal Cell Heterogeneity and Prognostic Significance in Multiple Myeloma
[Journal of Translational Medicine] Scientists investigated the heterogeneity of MSCs in multiple myeloma using single-cell RNA sequencing and bulk transcriptomic data.
Bone Mesenchymal Stem Cells Attenuate Hepatic Stellate Cell Activation and Liver Fibrosis through REDD1/Autophagy Pathway
[Stem Cells Translational Medicine] Researchers provide preliminary evidence for the protective roles of bone marrow MSCs in liver fibrosis through regulated in development and DNA damage response 1 (REDD1)/autophagy pathway.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
