Fibronectin 1 Activates WNT/β-Catenin Signaling to Induce Osteogenic Differentiation via Integrin β1 Interaction

Researchers report that fibronectin 1 promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts.
[Laboratory investigation]
Yang, C., Wang, C., Zhou, J., Liang, Q., He, F., Li, F., Li, Y., Chen, J., Zhang, F., Han, C., Liu, J., Li, K., & Tang, Y. (2020). Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction. Laboratory Investigation, 1–9. https://doi.org/10.1038/s41374-020-0451-2 Cite
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Piezo2 Expressed in Proprioceptive Neurons Is Essential for Skeletal Integrity

While loss of Piezo2 in chondrogenic or osteogenic lineages did not lead to human-like skeletal abnormalities, its loss in proprioceptive neurons led to spine malalignment and hip dysplasia.
[Nature Communications]
Assaraf, E., Blecher, R., Heinemann-Yerushalmi, L., Krief, S., Carmel Vinestock, R., Biton, I. E., Brumfeld, V., Rotkopf, R., Avisar, E., Agar, G., & Zelzer, E. (2020). Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity. Nature Communications, 11(1), 3168. https://doi.org/10.1038/s41467-020-16971-6 Cite
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Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo

Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
[International Journal of Molecular Sciences]
Samper Agrelo, I., Schira-Heinen, J., Beyer, F., Groh, J., Bütermann, C., Estrada, V., Poschmann, G., Bribian, A., Jadasz, J. J., Lopez-Mascaraque, L., Kremer, D., Martini, R., Müller, H. W., Hartung, H. P., Adjaye, J., Stühler, K., & Küry, P. (2020). Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. International Journal of Molecular Sciences, 21(12), 4350. https://doi.org/10.3390/ijms21124350 Cite
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Bone Regeneration Capacities of Alveolar Bone Mesenchymal Stem Cells Sheet in Rabbit Calvarial Bone Defect

Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
Liu, Y., Wang, H., Dou, H., Tian, B., Li, L., Jin, L., Zhang, Z., & Hu, L. (2020). Bone regeneration capacities of alveolar bone mesenchymal stem cells sheet in rabbit calvarial bone defect: Journal of Tissue Engineering. https://doi.org/10.1177/2041731420930379 Cite
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Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39-CD73 Signaling Pathway

Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
[Journal of Autoimmunity]
Dang, J., Xu, Z., Xu, A., Liu, Y., Fu, Q., Wang, J., Huang, F., Zheng, Y., Qi, G., Sun, B., Bellanti, J. A., Kandalam, U., Emam, H. A., Jarjour, W., & Zheng, S. G. (2020). Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39−CD73 signaling pathway. Journal of Autoimmunity, 102491. https://doi.org/10.1016/j.jaut.2020.102491 Cite
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Regenerative Potential of Wharton’s Jelly-Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of WJ‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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Nanospheres Loaded with Curcumin Improve the Bioactivity of Umbilical Cord Blood-Mesenchymal Stem Cells via c-Src Activation during the Skin Wound Healing Process

Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
[Cells]

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Emmes Announces Its Work on a Phase III Clinical Trial for Breakthrough Therapy Designation Product

Emmes announced that it provided the Phase III clinical trial support for a new investigational cell therapy that offers a promising treatment opportunity for patients who need an allogeneic bone marrow transplant.
[Emmes (PR Newswire, Inc.)]
Press Release
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Plasma Membrane Vesicles of Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Acetaminophen-Induced Damage in HepG2 Cells: A Novel Stem Cell Therapy

PMVs from human umbilical cord (hUC) MSCs were prepared with an improved procedure including a chemical enucleation step followed by a mechanical extrusion. Plasma membrane vesicles of hUCMSCs were characterized and supplemented to hepatocyte cultures.
[Stem Cell Research & Therapy]
Lin, M., Li, S., Yang, L., Ye, D., Xu, L., Zhang, X., … Wei, C. (2020). Plasma membrane vesicles of human umbilical cord mesenchymal stem cells ameliorate acetaminophen-induced damage in HepG2 cells: a novel stem cell therapy. Stem Cell Research & Therapy, 11(1), 225. https://doi.org/10.1186/s13287-020-01738-z Cite
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Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
[Cell Biology and Toxicology]
Song, Y., Wang, B., Zhu, X., Hu, J., Sun, J., Xuan, J., & Ge, Z. (2020). Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09530-8 Cite
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Cross Talk between Mesenchymal and Glioblastoma Stem Cells: Communication beyond Controversies

The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
[Stem Cells Translational Medicine]
Bajetto, A., Thellung, S., Dellacasagrande, I., Pagano, A., Barbieri, F., & Florio, T. (n.d.). Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0161 Cite
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