Scientists found that LPS, flagellin, dsDNA, nigericin, or LPS combined with nigericin could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells.
[Cell Death & Disease]
6445218 SED4YGTA items 1 apa default asc 1
Zhang, C., Zhao, C., Chen, X., Tao, R., Wang, S., Meng, G., Liu, X., Shao, C., & Su, X. (2020). Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages. Cell Death & Disease, 11(6), 1–13. https://doi.org/10.1038/s41419-020-2664-0 Cite
Functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity.
6445218 T9HH8RIZ items 1 apa default asc 1
Ambrosi, T. H., Goodnough, L. H., Steininger, H. M., Hoover, M. Y., Kim, E., Koepke, L. S., Marecic, O., Zhao, L., Seita, J., Bishop, J. A., Gardner, M. J., & Chan, C. K. F. (n.d.). Geriatric fragility fractures are associated with a human skeletal stem cell defect. Aging Cell, n/a(n/a), e13164. https://doi.org/10.1111/acel.13164 Cite
The authors investigated whether damage-induced transforming growth factor β signaling impaired the expression and function of T-cell factor 4, using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors.
[Journal of Cell Science]
6445218 PN5RRH3X items 1 apa default asc 1
The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discusses the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
Researchers report that fibronectin 1 promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts.
6445218 J88CEPNB items 1 apa default asc 1
Yang, C., Wang, C., Zhou, J., Liang, Q., He, F., Li, F., Li, Y., Chen, J., Zhang, F., Han, C., Liu, J., Li, K., & Tang, Y. (2020). Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction. Laboratory Investigation, 1–9. https://doi.org/10.1038/s41374-020-0451-2 Cite
While loss of Piezo2 in chondrogenic or osteogenic lineages did not lead to human-like skeletal abnormalities, its loss in proprioceptive neurons led to spine malalignment and hip dysplasia.
6445218 SFBWXGD9 items 1 apa default asc 1
Assaraf, E., Blecher, R., Heinemann-Yerushalmi, L., Krief, S., Carmel Vinestock, R., Biton, I. E., Brumfeld, V., Rotkopf, R., Avisar, E., Agar, G., & Zelzer, E. (2020). Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity. Nature Communications, 11(1), 3168. https://doi.org/10.1038/s41467-020-16971-6 Cite
Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
[International Journal of Molecular Sciences]
6445218 Z3SDSJFJ items 1 apa default asc 1
Samper Agrelo, I., Schira-Heinen, J., Beyer, F., Groh, J., Bütermann, C., Estrada, V., Poschmann, G., Bribian, A., Jadasz, J. J., Lopez-Mascaraque, L., Kremer, D., Martini, R., Müller, H. W., Hartung, H. P., Adjaye, J., Stühler, K., & Küry, P. (2020). Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. International Journal of Molecular Sciences, 21(12), 4350. https://doi.org/10.3390/ijms21124350 Cite
Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
1254621 Y7XANNDI items 1 apa default asc 1
Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
[Journal of Autoimmunity]
1254621 4EQAK4JN items 1 apa default asc 1
Dang, J., Xu, Z., Xu, A., Liu, Y., Fu, Q., Wang, J., Huang, F., Zheng, Y., Qi, G., Sun, B., Bellanti, J. A., Kandalam, U., Emam, H. A., Jarjour, W., & Zheng, S. G. (2020). Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39−CD73 signaling pathway. Journal of Autoimmunity, 102491. https://doi.org/10.1016/j.jaut.2020.102491 Cite
The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of WJ‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
Sorry, but the selected Zotpress account can't be found.