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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Mesenchymal Stem Cell-Secreted KGF Ameliorates Acute Lung Injury via the Gab1/ERK/NF-κB Signaling Axis
[Cellular & Molecular Biology Letters] Researchers focused on investigating the impact of keratinocyte growth factor (KGF) secreted from MSCs on acute lung injury, and clarifying its specific mechanism in regulating the expression of epithelial sodium channel.
Integrin Tension Represents the Directed Differentiation of Mesenchymal Stem Cells via Mechanoadaptation
[ACS Nano] Researchers applied reversible shearing DNA-based tension probes to assess MSCs’ integrin tension during spreading after biochemical induction to osteogenesis and chondrogenesis.
In Vivo Generation of CAR Macrophages via the Enucleated Mesenchymal Stem Cell Delivery System for Glioblastoma Therapy
[Proceedings of the National Academy of Sciences of the United States of America] Investigators utilized enucleated MSC vehicles for the targeted delivery of chimeric antigen receptor (CAR)-encoding plasmid to reprogram glioma-associated microglia/macrophages, thereby achieving CAR-macrophage preparation in vivo.
GLUL Mediates FOXO3 O-GlcNAcylation to Regulate the Osteogenic Differentiation of BMSCs and Senile Osteoporosis
[Cell Death & Differentiation] Scientists found that glutamine synthetase (GLUL) expression is downregulated in the bone marrow MSCs (BMSCs) of senile osteoporosis patients. Mice with BMSC-specific Glul-knockout exhibits dysplasia of the skull and phalanges due to disordered osteogenic differentiation.
Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D-Printed Titanium Truss
[Advanced Healthcare Materials] The authors investigated the effect of mechanotransduction on human MSCs attached to structural elements of an implant, specifically a titanium truss element.
Advances in Photobiomodulation: Effects on Mesenchymal Stem Cells and their Paracrine Factors
[Stem Cell Reviews and Reports] Investigators explore the current advancements in photobiomodulation technology and its application in MSC research, with a focus on understanding its mechanisms and therapeutic potential.
Mesoblast and FDA Align on Key Items for Revascor® Biologic License Application in Ischemic Heart Failure
[Mesoblast (GlobeNewswire)] Mesoblast announced alignment with the US FDA on items required for filing a Biologics License Application for Revascor® (rexlemestrocel-L) in the treatment of patients with ischemic heart failure with reduced ejection fraction and inflammation.
Stepwise Differentiation of Airway Epithelial Cells from Human Tonsil-Derived Mesenchymal Stem Cells
[Stem Cell Research & Therapy] Investigators developed an alternative approach to respiratory epithelial regeneration using human tonsil-derived MSCs to induce epithelial cell differentiation through a stepwise process.
Gelated Microvesicle-Mediated Delivery of Mesenchymal Stem Cell Mitochondria for the Treatment of Myocardial Infarction
[Proceedings of the National Academy of Sciences of the United States of America] Scientists introduced a gelated microvesicle–based mitochondria delivery system designed to deliver active MSC mitochondria to injured cells, rescuing mitochondrial dysfunction and thereby treating myocardial infarction.
A Review on Mesenchymal Stem Cells and Their Secretome in Hepatocellular Carcinogenesis and Its Related Signaling Pathways: Recent Update
[Discover Oncology] The authors summarize the role of MSCs in hepatocellular carcinoma (HCC), highlighting its involvement in different cell signaling pathways, including NF-κB, Wnt/β-catenin, Notch1, Stat3, and TGF-β, which play a significant role in HCC.
Divide-and-Conquer Strategy with Engineered Ossification Center Organoids for Rapid Bone Healing through Developmental Cell Recruitment
[Nature Communications] Researchers engineered an ossification center-like organoid that consists of an inner-core bone morphogenetic and neurotrophic spheroid generated via MSCs-loaded 3D printing, alongside the interstitially distributed outer-shell proangigenic neurotrophic phase.
Therapeutic Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on ER Stress in a Murine Model of Metabolic Dysfunction-Associated Steatohepatitis: An In Vivo and In...
[Stem Cell Research & Therapy] Scientists investigated the therapeutic mechanism of adipose tissue-derived stem cells in metabolic dysfunction-associated steatohepatitis, focusing on their modulation of endoplasmic reticulum stress in hepatocytes.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
