Category Archives: Mesenchymal Cell

Mesenchymal Cell News is an online publication and email newsletter that delivers updates on the latest research in the mesenchymal stem cell field.
Subscribe
Mesenchymal Cell News is a weekly email newsletter covering topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.

Induction of ASC Pyroptosis Requires Gasdermin D or Caspase-1/11-Dependent Mediators and IFNβ from Pyroptotic Macrophages

Scientists found that LPS, flagellin, dsDNA, nigericin, or LPS combined with nigericin could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells.
[Cell Death & Disease]
Zhang, C., Zhao, C., Chen, X., Tao, R., Wang, S., Meng, G., Liu, X., Shao, C., & Su, X. (2020). Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages. Cell Death & Disease, 11(6), 1–13. https://doi.org/10.1038/s41419-020-2664-0 Cite
Full Article
Bookmark

No account yet? Register

Share

Geriatric Fragility Fractures are Associated with a Human Skeletal Stem Cell Defect

Functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity.
[Aging Cell]
Ambrosi, T. H., Goodnough, L. H., Steininger, H. M., Hoover, M. Y., Kim, E., Koepke, L. S., Marecic, O., Zhao, L., Seita, J., Bishop, J. A., Gardner, M. J., & Chan, C. K. F. (n.d.). Geriatric fragility fractures are associated with a human skeletal stem cell defect. Aging Cell, n/a(n/a), e13164. https://doi.org/10.1111/acel.13164 Cite
Full Article
Bookmark

No account yet? Register

Share

TGF-β-Driven Downregulation of the Transcription Factor TCF7L2 affects Wnt/β-Catenin Signaling in PDGFRα+ Fibroblasts

The authors investigated whether damage-induced transforming growth factor β signaling impaired the expression and function of T-cell factor 4, using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors.
[Journal of Cell Science]
Contreras, O., Soliman, H., Theret, M., Rossi, F. M. V., & Brandan, E. (2020). TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts. Journal of Cell Science, 133(12). https://doi.org/10.1242/jcs.242297 Cite
Abstract
Bookmark

No account yet? Register

Share

Exosomes: Roles and Therapeutic Potential in Osteoarthritis

The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discusses the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
[Bone Research]
Ni, Z., Zhou, S., Li, S., Kuang, L., Chen, H., Luo, X., Ouyang, J., He, M., Du, X., & Chen, L. (2020). Exosomes: roles and therapeutic potential in osteoarthritis. Bone Research, 8(1), 1–18. https://doi.org/10.1038/s41413-020-0100-9 Cite
Full Article
Bookmark

No account yet? Register

Share

Fibronectin 1 Activates WNT/β-Catenin Signaling to Induce Osteogenic Differentiation via Integrin β1 Interaction

Researchers report that fibronectin 1 promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts.
[Laboratory investigation]
Yang, C., Wang, C., Zhou, J., Liang, Q., He, F., Li, F., Li, Y., Chen, J., Zhang, F., Han, C., Liu, J., Li, K., & Tang, Y. (2020). Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction. Laboratory Investigation, 1–9. https://doi.org/10.1038/s41374-020-0451-2 Cite
Abstract
Bookmark

No account yet? Register

Share

Piezo2 Expressed in Proprioceptive Neurons Is Essential for Skeletal Integrity

While loss of Piezo2 in chondrogenic or osteogenic lineages did not lead to human-like skeletal abnormalities, its loss in proprioceptive neurons led to spine malalignment and hip dysplasia.
[Nature Communications]
Assaraf, E., Blecher, R., Heinemann-Yerushalmi, L., Krief, S., Carmel Vinestock, R., Biton, I. E., Brumfeld, V., Rotkopf, R., Avisar, E., Agar, G., & Zelzer, E. (2020). Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity. Nature Communications, 11(1), 3168. https://doi.org/10.1038/s41467-020-16971-6 Cite
Full Article
Bookmark

No account yet? Register

Share

Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo

Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
[International Journal of Molecular Sciences]
Samper Agrelo, I., Schira-Heinen, J., Beyer, F., Groh, J., Bütermann, C., Estrada, V., Poschmann, G., Bribian, A., Jadasz, J. J., Lopez-Mascaraque, L., Kremer, D., Martini, R., Müller, H. W., Hartung, H. P., Adjaye, J., Stühler, K., & Küry, P. (2020). Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. International Journal of Molecular Sciences, 21(12), 4350. https://doi.org/10.3390/ijms21124350 Cite
Full Article
Bookmark

No account yet? Register

Share

Bone Regeneration Capacities of Alveolar Bone Mesenchymal Stem Cells Sheet in Rabbit Calvarial Bone Defect

Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
Liu, Y., Wang, H., Dou, H., Tian, B., Li, L., Jin, L., Zhang, Z., & Hu, L. (2020). Bone regeneration capacities of alveolar bone mesenchymal stem cells sheet in rabbit calvarial bone defect: Journal of Tissue Engineering. https://doi.org/10.1177/2041731420930379 Cite
Full Article
Bookmark

No account yet? Register

Share

Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39-CD73 Signaling Pathway

Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
[Journal of Autoimmunity]
Dang, J., Xu, Z., Xu, A., Liu, Y., Fu, Q., Wang, J., Huang, F., Zheng, Y., Qi, G., Sun, B., Bellanti, J. A., Kandalam, U., Emam, H. A., Jarjour, W., & Zheng, S. G. (2020). Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39−CD73 signaling pathway. Journal of Autoimmunity, 102491. https://doi.org/10.1016/j.jaut.2020.102491 Cite
Abstract
Bookmark

No account yet? Register

Share

Regenerative Potential of Wharton’s Jelly-Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of WJ‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
Abstract
Bookmark

No account yet? Register

Share

Nanospheres Loaded with Curcumin Improve the Bioactivity of Umbilical Cord Blood-Mesenchymal Stem Cells via c-Src Activation during the Skin Wound Healing Process

Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
[Cells]

Sorry, but the selected Zotpress account can't be found.

AbstractGraphical Abstract
Bookmark

No account yet? Register

Share
Share