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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
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Calcitonin Receptor Downregulation and Exercise-Conditioned Blood Enable Systemic Muscle Stem Cell Proliferation
[Nature Communications] Researchers found that increased loading reduces calcitonin receptor (CalcR) expression, and forced activation of protein kinase A, a downstream of CalcR signaling, suppresses muscle stem cell proliferation.
Transient Overexpression of hPKM2 in Porcine Cardiomyocytes Prevents Heart Failure after Myocardial Infarction
[Nature Communications] Researchers used a targeted, non-viral modified mRNA system to transiently boost expression of a regenerative enzyme, pyruvate kinase muscle isozyme M2, in heart muscle cells of juvenile and adult pig models after ischemic injury.
Mechanical Unloading Coupled with Coronary Reperfusion Stimulates Cardiomyocyte Proliferation and Prevents Unloading-Induced Fibrosis after Myocardial Infarction
[Basic Research In Cardiology] The authors investigated the effect coronary reperfusion coupled with mechanical unloading has on myocardial fibrosis, and the impact of these changes in extracellular matrix on the heart's regenerative potential.
TBC1D1 Functions As a Negative Regulator of Satellite Cells for Muscle Regeneration
[Nature Communications] Scientists showed that TBC1D1, a Rab GTPase activating protein related to AS160, forms a super-complex with AS160 and STAT3 to retain the AS160–STAT3 complex in the cytosol.
TGFβ-Smad3 Signaling Restores Cell-Autonomous Srsf1-Mediated Splicing of Fibronectin in Aged Skeletal Muscle Stem Cells
[Nature Communications] Investigators demonstrated that activated muscle stem cells secrete an autoregulatory fibronectin splice variant containing the EDB extra domain, which is not expressed by accessory cells in the niche.
The Canonical ER Stress IRE1α/XBP1 Pathway Mediates Skeletal Muscle Wasting during Pancreatic Cancer Cachexia
[EMBO Molecular Medicine] Researchers demonstrated that the IRE1α/XBP1 branch of the unfolded protein response promotes activation of the ubiquitin–proteasome system, autophagy, JAK-STAT3 signaling, and fatty acid metabolism in the skeletal muscle of the KPC mouse model of pancreatic cancer cachexia.
Distinct Populations of Vascular Smooth Muscle and Sinoatrial Progenitors Are Localized Adjacent to Pro-Epicardium
[Cell Reports] Scientists found that the pro-epicardial region contains three adjacent cell clusters that have distinct gene expression profiles and distinct spatial locations.
PDZ Domain Containing Protein 1 Aggravates Mouse Vascular Smooth Muscle Cells Calcification via PDZ1 Domain Mediated β-catenin Stabilization and Nuclear Translocation
[Communications Biology] Investigators showed that the expression levels of PDZ domain containing 1 are notably boosted in calcified mice aortas, human and mouse vascular smooth muscle cells.
Impact of Dystrophin Deficiency on Vascular Smooth Muscle Cell
[Scientific Reports] Scientists examined how dystrophin deficiency alters vascular smooth muscle cells (VSMCs) plasticity using mdx mice and Duchenne muscular dystrophy patient-derived iPSC VSMCs.
Cardiomyocyte Maturation and Proliferation Is a Flip Coin
[BMC Cardiovascular Disorders] The authors discuss the relationship between postnatal cardiomyocyte maturation and cardiomyocyte proliferation.
Grant to Sokol Todi, Ph.D., to Fund Research into Kennedy’s Disease
[Wayne State University] The Kennedy’s Disease Association has awarded Dr. Sokol Todi a $200,000 grant to advance research in spinal and bulbar muscular atrophy, also known as Kennedy's Disease.
Przytycki Lab Secures Funding for Project on Skeletal Muscle Spatial Transcriptomics
[Boston University] The LAMA2 Association in France has awarded $28,982 to Pawel Przytycki in support of his pilot project entitled “Spatial Transcriptomics in Pediatric Human LAMA2 Skeletal Muscle”.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
