Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
Sarepta Therapeutics, Inc. and Codiak BioSciences, Inc. announced a global research and option agreement to design and develop engineered exosome therapeutics to deliver gene therapy, gene editing and RNA technologies for neuromuscular diseases.
[Sarepta Therapeutics, Inc.]
Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]
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Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., Howe, K. L., Jarr, K.-U., Flores, A. M., Tsantilas, P., Tsao, N., Rao, A., Newman, A. A. C., Eberhard, A. V., Priest, J. R., Ruusalepp, A., Pasterkamp, G., Maegdefessel, L., Miller, C. L., … Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006348117 Cite
Researchers described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]
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Human MuStem cell grafting into infarcted rat heart attenuates adverse tissue remodeling and preserves cardiac function hMuStem cells preserve function of infarcted heart: Molecular Therapy - Methods & Clinical Development. (n.d.). Retrieved June 17, 2020, from https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30133-9 Cite
Investigators found that protein and mRNA expression levels of PHF20 were decreased during myogenic differentiation in C2C12 cells.
[Cell Death & Differentiation]
The authors found that rexinoid x receptor signaling associated with the distribution of myogenin at poised enhancers and a distinct E-box motif. They also found an association of myogenin with rexinoid-responsive gene expression and identified an epigenetic signature related to histone acetyltransferase p300.
The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]
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Scientists showed a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6−/− myoblasts.
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Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
In vitro cultures of synthetic vascular smooth muscle cells (VSMCs) showed decreased expression of contractile markers CNN1, αSMA and SM22α and an increase in synthetic marker S100A4 compared to contractile VSMCs.
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Furmanik Malgorzata, Chatrou Martijn, van Gorp Rick H, Akbulut Asim, Willems Brecht, Schmidt Harald HHW, van Eys Guillaume, Bochaton-Piallat Marie-Luce, Proudfoot Diane, Biessen Erik AL, Hedin Ulf, Matic Ljubica, Mees Barend, Shanahan Catherine M, Reutelingsperger Chris, & Schurgers Leon J. (n.d.). Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316159 Cite