Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Category Archives: Muscle Cell
Muscle Cell NewsMuscle Cell News is an online publication and email newsletter dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News is a publication covering the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
Virtual Lab Tours for Recruitment and Outreach
Trump to Suspend New Visas for Foreign Scholars
With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Sarepta Therapeutics and Codiak BioSciences Collaborate to Research and Develop Exosome-Based Therapeutics for Rare Diseases
Sarepta Therapeutics, Inc. and Codiak BioSciences, Inc. announced a global research and option agreement to design and develop engineered exosome therapeutics to deliver gene therapy, gene editing and RNA technologies for neuromuscular diseases.
[Sarepta Therapeutics, Inc.]
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Clonally Expanding Smooth Muscle Cells Promote Atherosclerosis by Escaping Efferocytosis and Activating the Complement Cascade
Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]
Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., Howe, K. L., Jarr, K.-U., Flores, A. M., Tsantilas, P., Tsao, N., Rao, A., Newman, A. A. C., Eberhard, A. V., Priest, J. R., Ruusalepp, A., Pasterkamp, G., Maegdefessel, L., Miller, C. L., … Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006348117 Cite
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Human MuStem Cell Grafting Into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart
Researchers described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]
Human MuStem cell grafting into infarcted rat heart attenuates adverse tissue remodeling and preserves cardiac function hMuStem cells preserve function of infarcted heart: Molecular Therapy - Methods & Clinical Development. (n.d.). Retrieved June 17, 2020, from https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30133-9 Cite
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Yin Yang 1 Is Required for PHD Finger Protein 20-Mediated Myogenic Differentiation In Vitro and In Vivo
Investigators found that protein and mRNA expression levels of PHF20 were decreased during myogenic differentiation in C2C12 cells.
[Cell Death & Differentiation]
Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo | Cell Death & Differentiation. (n.d.). Retrieved June 18, 2020, from https://www.nature.com/articles/s41418-020-0580-6 Cite
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Dissecting Myogenin-Mediated Retinoid X Receptor Signaling in Myogenic Differentiation
The authors found that rexinoid x receptor signaling associated with the distribution of myogenin at poised enhancers and a distinct E-box motif. They also found an association of myogenin with rexinoid-responsive gene expression and identified an epigenetic signature related to histone acetyltransferase p300.
[Communications Biology]
Khilji, S., Hamed, M., Chen, J., & Li, Q. (2020). Dissecting myogenin-mediated retinoid X receptor signaling in myogenic differentiation. Communications Biology, 3(1), 1–12. https://doi.org/10.1038/s42003-020-1043-9 Cite
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Intracellular Calcium Leak in Heart Failure and Atrial Fibrillation: A Unifying Mechanism and Therapeutic Target
The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]
Dridi, H., Kushnir, A., Zalk, R., Yuan, Q., Melville, Z., & Marks, A. R. (2020). Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target. Nature Reviews Cardiology, 1–16. https://doi.org/10.1038/s41569-020-0394-8 Cite
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The Importance of the ZBED6-IGF2 Axis for Metabolic Regulation in Mouse Myoblast Cells
Scientists showed a significant enrichment of mitochondrial membrane proteins among proteins showing altered expression in Zbed6−/− myoblasts.
[FASEB Journal]
Younis, S., Naboulsi, R., Wang, X., Cao, X., Larsson, M., Sargsyan, E., Bergsten, P., Welsh, N., & Andersson, L. (n.d.). The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.201901321R Cite
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Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix
Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research]
Wu Chi-Chung, Jeratsch Sylvia, Graumann Johannes, & Stainier Didier. (n.d.). Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316303 Cite
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Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification
In vitro cultures of synthetic vascular smooth muscle cells (VSMCs) showed decreased expression of contractile markers CNN1, αSMA and SM22α and an increase in synthetic marker S100A4 compared to contractile VSMCs.
[Circulation Research]
Furmanik Malgorzata, Chatrou Martijn, van Gorp Rick H, Akbulut Asim, Willems Brecht, Schmidt Harald HHW, van Eys Guillaume, Bochaton-Piallat Marie-Luce, Proudfoot Diane, Biessen Erik AL, Hedin Ulf, Matic Ljubica, Mees Barend, Shanahan Catherine M, Reutelingsperger Chris, & Schurgers Leon J. (n.d.). Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316159 Cite
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