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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Dusp14-Mediated Dephosphorylation of MLKL Protects Against Cardiomyocyte Necroptosis in Hypothyroidism-Induced Heart Failure
[Circulation] Scientists addressed the urgent need to explore the pathologic mechanism of hypothyroidism-induced heart failure in detail and to discover and develop drugs that can target and manage heart failure in patients with hypothyroidism.
Allogenic Mitochondria Transfer Improves Cardiac Function in iPS-Cell-Differentiated Cardiomyocytes of a Patient With Barth Syndrome
[Experimental & Molecular Medicine] Investigators explored the possibility of using stem-cell-derived cardiomyocytes as a source of mitochondrial transplantation to treat Barth syndrome.
Cardiomyocyte-Derived YOD1 Promotes Pathological Cardiac Hypertrophy by Deubiquitinating and Stabilizing STAT3
[Science Advances] Scientists observed that the deubiquitinating enzyme YOD1 was moderately elevated in human hypertrophic myocardium and mouse models. Cardiomyocyte-specific knockout of YOD1 reduced Ang II– and TAC-induced cardiac hypertrophy.
AEBP1 As a Promising Therapeutic Target for Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus: Convergent Evidence from Mendelian Randomization and Functional Validation
[Metabolism Clinical and Experimental] Potential causative genetic factors in skeletal muscle and blood causally associated with type 2 diabetes mellitus were identified by Summary-data-based Mendelian randomization analysis.
Smooth Muscle-Specific HuR Knockout Attenuates Vascular Calcification
[Journal of Molecular and Cellular Cardiology] Researchers generated smooth muscle-specific human antigen R (HuR) knockout mice to investigate the function of HuR in vascular calcification.
EDIL3 Regulates Pulmonary Artery Smooth Muscle Cell Proliferation and Migration via Integrin αVβ3/ERK1/2 Axis in Pulmonary Hypertension
[European Journal of Pharmacology] Researchers found that EDIL3 levels were elevated in patients with idiopathic pulmonary arterial hypertension, as well as in hypoxia-treated pulmonary artery smooth muscle cells compared to normoxia-treated controls.
Stem Cell Aging and Rejuvenation in the Skeletal Muscle System
[Rejuvenation Research] The authors explore some of the recent discoveries of how misregulation of intrinsic and extrinsic mechanisms drives the decline of muscle stem cell (MuSC) function in aging muscles, and we discuss new strategies to rejuvenate aged MuSC function for regenerative medicine.
HeartBeat.bio and biotx.ai Sign License and Technology Access Agreement to Identify Novel Targets in Heart Failure
[HeartBeat.bio (Biotech Newswire)] HeartBeat.bio AG and biotx.ai GmbH announced a strategic partnership to identify and validate novel therapeutic targets in heart failure. The collaboration combines biotx.ai’s causal mapping of the genome for target discovery with HeartBeat.bio’s human-based Cardioid Drug Discovery Platform to drive innovation in heart failure drug development.
Early-Stage Morphogenesis of T-Tubules in Rat Cardiomyocytes: The Role of pBIN1
[Circulation Research] To understand early-stage morphogenesis of cardiac transverse tubules (TTs), researchers utilized a scanning electron microscope equipped with a focused ion beam to reconstruct a 3-dimensional spatial profile of the developing TT network in cardiomyocytes from 2-week-old rats.
Insights into tissue- and Cell Type-Specific Effects of Grb10 on Pig Skeletal Muscle Growth by Multi-Omics Analysis
[Science China Life Sciences] Researchers identified the specificity of GRB10 in muscle tissue and cells between obese and lean pigs by combining genomics, transcriptomics, epigenomics, and single-cell transcriptomics.
Cardiomyocyte Growth on Cardiac Infusible Extracellular Matrix-Coated and Annealed Biodegradable Polyurethane Fibers
[Langmuir] Investigators explored strategies to mitigate shrinkage and enhance the functionality of polyurethane fibers for the cardiac cell culture.
Premature Cell Senescence Promotes Vascular Smooth Muscle Cell Phenotypic Modulation and Resistance to Re-Differentiation.
[Cardiovascular Research] DNA damage and senescence induce genes associated with de-differentiated/fibromyocytic vascular smooth muscle cells, and persistence of these cells in vivo.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
