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Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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Acquired Genetic and Cell-State Changes in IDH-Mutant Glioma Progression
[Nature] Researchers showed that malignant cell states transcriptionally resemble stages of normal glial–neuronal lineage development or a reactive mesenchymal-like state, mirroring states previously described in isocitrate dehydrogenase (IDH) wild-type glioblastoma.
Epigenetic Control of Microglial Mitochondrial Immunity by KAT7 Drives Alzheimer’S Disease Pathogenesis
[Neuron] Investigators identified the histone acetyltransferase KAT7 as a central epigenetic regulator that links chromatin remodeling to mitochondrial immune activation.
IQGAP3 Bridges Matrix Stiffness with Glioma Stem Cell Maintenance and Radioresistance by Stabilizing SOX2
[Nature Communications] Differential gene expression revealed that stiff matrices induce expression of IQ Motif Containing GTPase Activating Protein 3 (IQGAP3) through YAP1 and TEAD transcription factors in GBM stem cells.
Microglial CD31 Suppresses aβ Clearance and Promotes Alzheimer Pathology in 5×FAD Mice
[Nature Communications] The authors showed that CD31, a recognized endothelial marker, is predominantly expressed in microglia but not in neurons or astrocytes, and it is significantly elevated in the brains of Alzheimer’s disease patients and mouse models.
miR-151-5p Regulates Neural Stem Cell Fate by Targeting APH1A to Modulate Notch Signaling Gradients
[Stem Cell Reports] Researchers found miR-151-5p is expressed in neural stem cells (NSCs) of the developing mouse cerebral cortex. Conditional knockout of miR-151-5p increased SOX2 expression in NSCs and enhanced their proliferative capacity.
Overexpression of miR-219 As a Potential Therapeutic Strategy of Glioblastoma Cells In Vitro
[Scientific Reports] Scientists evaluated miR-219 effects on glioblastoma in vitro, in combination with radiation and temozolomide. They indicated that miR-219 may modulate tumor-related processes through the negative regulation of target genes such as REST and AKAP13.
A 2026 Perspective on Neural Stem Cells and Glial Plasticity
[Trends in Cell Biology] Investigators focus particularly on astrocytes and integrate evidence from invertebrate models demonstrating that glial cells possess an intrinsic capacity for neurogenesis.
Keck Foundation Funds Three Innovative Early-Career Salk Projects
[The Salk Institute] Three Salk faculty members, Drs. Sung Han, Daniel Hollern, and Graham McVicker, have been chosen as Keck Scholars, alongside corresponding graduate students as Keck Fellows, in a special W. M. Keck Foundation Bridge Funding Initiative.
An Oncostatin M Receptor and Chloride Intracellular Channel 1 Crosstalk Drives Key Oncogenic Pathways in Glioblastoma
[Signal Transduction and Targeted Therapy] Researchers uncovered a bidirectional crosstalk between Oncostatin M receptor (OSMR) and tmCLIC1 in glioblastoma, essential for fueling its malignant growth.
Ferroptosis Susceptibility in Hippocampal Neural Precursor Cells Influences Neurogenesis and Memory across Aging
[Cell Stem Cell] Scientists tested whether ferroptosis-related vulnerability contributes to the regulation of hippocampal neural precursor cells and their progeny.
Light- and Chemical-Induced Ciliary Signaling Governs Dorsal/Ventral Regionalization of Human Telencephalic Organoids
[Nature Communications] Using a human telencephalic organoid model, investigators performed comprehensive proteomic profiling of neural stem/progenitor cell cilia and found enrichment in GTPase signaling.
Mapping Neuro-Vascular Unit Communications Reveals Distinct Angiogenic Programs across Developing Mouse Brain Regions
[Nature Communications] Researchers combined spatial transcriptomics with region-resolved endothelial single-cell RNA sequencing in the postnatal mouse brain to map cortical and thalamic neurovascular unit communication dynamics.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
