Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Engrafted Nitrergic Neurons Derived from hPSCs Improve Gut Dysmotility in Mice

June 26, 2025

[Nature] Scientists introduced a platform based on hPSCs for therapeutic development targeting gastrointestinal motility disorders.

Cholinergic Basal Forebrain Neurons Regulate Vascular Dynamics and Cerebrospinal Fluid Flux

June 26, 2025

[Nature Communications] Investigators demonstrated that cholinergic neurons modulate blood oxygenation level-dependent-cerebrospinal fluid coupling and glymphatic function.

An Organ-Chip Model of Sporadic ALS Using iPSC-Derived Spinal Cord Motor Neurons and an Integrated Blood-Brain-Like Barrier

June 26, 2025

[Cell Stem Cell] The authors combined motor neurons from patients with early-onset disease with brain microvascular endothelial-like cells in a microfluidic device and added media flow, which enhances neuronal maturation and improved cellular health.

The lncRNA Gas5 Is an Activity-Responsive Scaffold That Mediates cAMP-Dependent Synaptic Plasticity

June 26, 2025

[Science Signaling] Investigators explored the effect of cAMP second-messenger signaling and metabotropic glutamate receptor signaling on the transcriptome in hippocampal neurons and how these pathways operate in distinct and coordinated manners to induce structural changes.

The Mechanisms Underlying TDP-43-Associated Neurodegeneration in Alzheimer’s Disease and Related Dementias

June 26, 2025

[Molecular Psychiatry] Investigators summarize the current understanding of TDP-43 pathology in Alzheimer’s disease and Alzheimer’s disease-related dementias, with a focus on its role in disease progression.

Microglia Promote Inflammatory Cell Death upon Neuronal Mitochondrial Impairment during Neurodegeneration

June 26, 2025

[Nature Structural & Molecular Biology] To investigate the relationship between mitochondrial health, inflammation and neurodegeneration, scientists created a conditional Vps13d-knockout mouse.

Contribution of Glutamatergic Projections to Neurons in the Nonhuman Primate Substantia Nigra Pars Reticulata for Reactive Inhibition

June 26, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Scientists showed that neurons in the primate substantia nigra pars reticulata bidirectionally modulate activity to control action, decreasing firing rates to facilitate movements and increasing rates to suppress them.

Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

June 20, 2025

[Cell] Scientists demonstrated that midbrain cholinergic neuronal activity modulates oligodendrocyte precursor cell and diffuse midline glioma proliferation in a circuit-dependent manner.

Encoding the Glucose Identity by Discrete Hypothalamic Neurons via the Gut-Brain Axis

June 20, 2025

[Neuron] Researchers found that a subset of corticotropin-releasing factor-expressing neurons in the hypothalamic paraventricular nucleus respond specifically to D-glucose in the gut, separately from other macronutrients or sugars.

Loss of DOT1L Disrupts Neuronal Transcription and Leads to a Neurodevelopmental Disorder

June 18, 2025

[Brain] The authors defined the effects of partial DOT1L loss by applying bulk and single-nucleus RNA-sequencing, ChIP-sequencing, imaging, multielectrode array recordings, and behavioral analysis of zebrafish, and multiple mouse models.

Early Life High Fructose Impairs Microglial Phagocytosis and Neurodevelopment

June 18, 2025

[Nature] Investigators showed that offspring born to female mice fed a high-fructose diet and neonates exposed to high fructose exhibit decreased phagocytic activity in vivo.

Morphodynamics of Human Early Brain Organoid Development

June 18, 2025

[Nature] Researchers established long-term, live light-sheet microscopy on unguided brain organoids generated from fluorescently labelled hiPSCs, which enables tracking of tissue morphology, cell behaviors, and subcellular features over weeks of organoid development

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.