Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Calcium Overload Induced Mitochondrial and Lysosomal Dysfunction Is Regulated by Tousled-Like Kinase in A-Synucleinopathy

January 8, 2026

[Cell Death & Disease] Researchers found that calcium overload caused mitochondrial damage and lysosomal dysfunction, leading to cell death, and these cytotoxic processes were significantly mitigated by the loss of Tousled-like kinase.

USP25 Inhibition Ameliorates Parkinson’s Disease by Restoring Mitophagy

January 8, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Investigators found that USP25 exacerbated dopaminergic neuronal loss and motor deficits in murine models of Parkinson's disease by sabotaging the mitophagy machinery.

Adult Neural Stem Cells Mediate Hippocampal Synapse Elimination for Circuit Homeostasis through MERTK

January 8, 2026

[Proceedings of The National Academy of Sciences of The United States of America] The authors reported that mice in which radial-like NSCs lack the phagocytic receptor MERTK exhibit reduced elimination of excitatory synapses, defective synaptic plasticity, and impaired formation of hippocampal learning and memory, but normal neurogenesis.

IDH-Mutant Gliomas Arise from Glial Progenitor Cells Harboring the Initial Driver Mutation

January 8, 2026

[Science] Scientists conducted deep sequencing on 142 tissues from 70 individuals with isocitrate dehydrogenase (IDH)–mutant gliomas comprising tumors, peritumoral cortex or subventricular zones, and blood.

Long-Range Axon Branching: Contributions to Brain Network Plasticity and Repair

January 7, 2026

[Nature Reviews Neuroscience] The authors consider whether axonal features could enable long-range and large-scale neuroplastic changes at a functional level, particularly following focal brain injury.

Research Award Will Accelerate Research to Map Brain Electrical Circuits

January 7, 2026

[University of Nottingham] Sidahmed Abayzeed, Assistant Professor in the Faculty of Engineering has received £200k for his project NeurOhmics – a platform that combines ultra-high-resolution optical microscopy based on electrical impedance and artificial intelligence for enhanced sensitivity.

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

January 6, 2026

[Advanced Science] Researchers conducted proteomic analyses of human iPSC-derived motor neurons carrying C9ORF72 mutations, alongside spinal ventral horns from mice with pathogenic C9orf72-mutations.

Distinct Endocannabinoids Specifically Signal to Astrocytes or Neurons in the Adult Mouse Hippocampus

January 6, 2026

[Nature Neuroscience] Investigators showed that 2-arachidonoylglycerol selectively signals to neurons, eliciting the depression, which is mediated exclusively by neuronal mechanisms.

TGFβ Signaling Mediates Microglial Resilience to Spatiotemporally Restricted Myelin Degeneration

January 6, 2026

[Nature Neuroscience] By examining spinal cord white matter tracts in mice, the authors determined that myelin degeneration was particularly prominent in the dorsal column during normal aging.

NLRP3 Facilitates α-Synuclein-Induced Dopaminergic Neuronal Senescence in a Mouse Model of Parkinson’s Disease through SATB1/DNA Damage/P21 Signaling Pathway

January 6, 2026

[Acta Pharmacologica Sinica] Scientists identified the cell type susceptible to α-synuclein-induced cellular senescence in the substantia nigra and investigated the specific role of microglia with a particular focus on the NLRP3 inflammasome.

Atypical Cell Cycle Regulation over Neural Stem Cell Expansion

January 6, 2026

[Stem Cell Reports] Using a conditional mouse model, we demonstrate that driving the expression of Spy1, in the Nestin-enriched NSC population of the brain, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation.

DMTF1 Up-Regulation Rescues Proliferation Defect of Telomere Dysfunctional Neural Stem Cells via the SWI/SNF-E2F Axis

January 6, 2026

[Science Advances] Investigators found that DMTF1, a transcription factor that regulates the Arf/p53 axis in cancer, is down-regulated in the NSCs of a premature aging model driven by telomerase deficiency.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.