 | | Vol. 11.22 – 8 June, 2022 |
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| Overexpression of nuclear HK2 increased leukemic stem cell properties and decreased differentiation, whereas selective nuclear HK2 knockdown promoted differentiation and decreased stem cell function.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that platelet-derived growth factor (PDGF) signaling induced N6-methyladenosine accumulation in glioblastoma stem cells to regulate mitophagy.
[Developmental Cell] |
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| The authors identified six mitochondria-affecting compounds that exhibited selective cytotoxicity against acute myeloid leukemia cells in vitro.
[Leukemia] |
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| Scientists defined the events that contributed to dynamic adaptation of glioblastoma (GBM) during treatment with human skin-derived induced neural stem cells releasing the pro-apoptotic agent TRAIL and developed strategies which converted initial tumor kill into sustained GBM suppression.
[Molecular Therapy Oncolytics] |
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| Glioblastoma (GBM) stem cells were divided into high and low β8 integrin subpopulations. Investigators assessed the proliferative, migratory, and angiogenic capacity of GBM cells and human brain microvascular endothelial cells.
[Cell Death & Disease] |
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| The authors investigated the effects associated with snail family transcriptional repressor 2 (SNAI2) on the proliferation of glioma stem cells to elucidate its underlying molecular mechanism in the development of glioma.
[Cell Death & Disease] |
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| Researchers investigated the role of AMP-activated protein kinase in the maintenance of breast CSCs state/function.
[Disease Models & Mechanisms] |
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| Scientists found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures.
[Cancer Gene Therapy] |
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| RNA-sequencing analyses of ALDH+ colon CSCs from colon cancer patient-derived organoids and xenografts showed CSCs to be enriched for neural development genes.
[iScience] |
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| The effect of cisplatin on mitochondrial activity was assessed by JC1 staining and expression of oxidative phosphorylation (OXPHOS) genes by RT-qPCR. Cisplatin-induced changes in Sirtuin 1 levels and activity were assessed by western blot.
[Journal of Translational Medicine] |
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| The authors discuss the mechanisms, pathophysiology, genetic predisposition and cells of origin of Barrett esophagus, and opine on the clinical implications and future research directions.
[Nature Reviews Gastroenterology & Hepatology] |
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| Oryzon Genomics, S.A. announced that the US FDA has granted Orphan Drug Designation to the company’s clinical stage LSD1 inhibitor iadademstat for the treatment of patients with small cell lung cancer.
[Oryzon Genomics, S.A.] |
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| Asher Biotherapeutics announced that it has entered into a clinical trial collaboration and supply agreement with Merck for a planned Phase Ia/Ib dose-escalation and expansion trial to evaluate AB248, Asher Bio’s novel investigational CD8-targeted interleukin 2.
[Asher Biotherapeutics] |
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| October 3 – 5, 2022
Vancouver, British Columbia, Canada |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | La Jolla Institute for Immunology – La Jolla, California, United States |
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| | Norwegian University of Science and Technology -Trondheim, Norway |
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| | Stem Cell Network – Ottawa, Ontario, Canada |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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