Cancer Stem Cell News Volume 11.22 | Jun 8 2022

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    2022-06-08 | CSCN 11.22


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.22 – 8 June, 2022
    TOP STORY

    The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem and Progenitor Cells to Maintain Stemness

    Overexpression of nuclear HK2 increased leukemic stem cell properties and decreased differentiation, whereas selective nuclear HK2 knockdown promoted differentiation and decreased stem cell function.
    [Nature Cell Biology]

    Full Article

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    PDGF Signaling Inhibits Mitophagy in Glioblastoma Stem Cells through N6-Methyladenosine

    Researchers demonstrated that platelet-derived growth factor (PDGF) signaling induced N6-methyladenosine accumulation in glioblastoma stem cells to regulate mitophagy.
    [Developmental Cell]

    AbstractGraphical Abstract

    Novel Mitochondria-Targeting Compounds Selectively Kill Human Leukemia Cells

    The authors identified six mitochondria-affecting compounds that exhibited selective cytotoxicity against acute myeloid leukemia cells in vitro.
    [Leukemia]

    Abstract

    Spatiotemporal Analysis of Induced Neural Stem Cell Therapy to Overcome Advanced Glioblastoma Recurrence

    Scientists defined the events that contributed to dynamic adaptation of glioblastoma (GBM) during treatment with human skin-derived induced neural stem cells releasing the pro-apoptotic agent TRAIL and developed strategies which converted initial tumor kill into sustained GBM suppression.
    [Molecular Therapy Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Paradoxical Role of β8 Integrin on Angiogenesis and Vasculogenic Mimicry in Glioblastoma

    Glioblastoma (GBM) stem cells were divided into high and low β8 integrin subpopulations. Investigators assessed the proliferative, migratory, and angiogenic capacity of GBM cells and human brain microvascular endothelial cells.
    [Cell Death & Disease]

    Full Article

    Transcription Factor SNAI2 Exerts Pro-Tumorigenic Effects on Glioma Stem Cells via PHLPP2-Mediated Akt Pathway

    The authors investigated the effects associated with snail family transcriptional repressor 2 (SNAI2) on the proliferation of glioma stem cells to elucidate its underlying molecular mechanism in the development of glioma.
    [Cell Death & Disease]

    Full Article

    AMP-Activated Protein Kinase Promotes Breast Cancer Stemness and Drug Resistance

    Researchers investigated the role of AMP-activated protein kinase in the maintenance of breast CSCs state/function.
    [Disease Models & Mechanisms]

    Abstract

    Extracellular Sialyltransferase ST6GAL1 in Breast Tumor Cell Growth and Invasiveness

    Scientists found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures.
    [Cancer Gene Therapy]

    Full Article

    Identification of a Neural Development Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for EGR2 in Tumorigenesis

    RNA-sequencing analyses of ALDH+ colon CSCs from colon cancer patient-derived organoids and xenografts showed CSCs to be enriched for neural development genes.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian Cancer

    The effect of cisplatin on mitochondrial activity was assessed by JC1 staining and expression of oxidative phosphorylation (OXPHOS) genes by RT-qPCR. Cisplatin-induced changes in Sirtuin 1 levels and activity were assessed by western blot.
    [Journal of Translational Medicine]

    Full Article

    How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
    REVIEWS

    Mechanisms and Pathophysiology of Barrett Esophagus

    The authors discuss the mechanisms, pathophysiology, genetic predisposition and cells of origin of Barrett esophagus, and opine on the clinical implications and future research directions.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    ORYZON announces FDA Orphan Drug Designation granted to iadademstat for treatment of Small Cell Lung Cancer

    Oryzon Genomics, S.A. announced that the US FDA has granted Orphan Drug Designation to the company’s clinical stage LSD1 inhibitor iadademstat for the treatment of patients with small cell lung cancer.
    [Oryzon Genomics, S.A.]

    Press Release

    Asher Bio Announces Clinical Trial Collaboration with Merck to Evaluate AB248 in Combination with KEYTRUDA® (pembrolizumab) in Patients with Locally Advanced or Metastatic Solid Tumors

    Asher Biotherapeutics announced that it has entered into a clinical trial collaboration and supply agreement with Merck for a planned Phase Ia/Ib dose-escalation and expansion trial to evaluate AB248, Asher Bio’s novel investigational CD8-targeted interleukin 2.
    [Asher Biotherapeutics]

    Press Release

    FEATURED EVENT

    Till & McCulloch Meetings

    October 3 – 5, 2022
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Candidate – Cancer Biology

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Fellow – Cancer Immunology & Genomics

    La Jolla Institute for Immunology – La Jolla, California, United States

    PhD Candidate – Cellular and Molecular Mechanisms of Cancer

    Norwegian University of Science and Technology -Trondheim, Norway

    Research Specialist – Stem Cells and Regenerative Medicine

    Stem Cell Network – Ottawa, Ontario, Canada

    Postdoctoral Fellow – Tumor Microenvironment in Metastasis

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    > See All Jobs

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