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Vol. 12.45 – 6 December, 2023
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Investigators showed SPINK1 to strongly associate with CD133 + hepatocellular carcinoma and tumor dedifferentiation.
[Nature Communications]
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PUBLICATIONSRanked by the impact factor of the journal
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Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.
[Small]
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Scientists developed a stem cell factor SOX9-based reporter for isolating CSCs in primary tumors and metastases of spontaneous mammary tumor models.
[Science Advances]
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Investigators found that increased RAB27B in leukemia stem cells prevented their senescence and maintained their stemness in vitro and in vivo.
[Leukemia]
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Scientists explored novel miRNA–mRNA regulatory mechanisms that contribute to osimertinib resistance in lung cancer. They found that miR-204 expression in osimertinib-resistant lung cancer cells was markedly reduced compared to that in osimertinib-sensitive parental cells.
[Molecular Therapy – Nucleic Acids]
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Researchers demonstrated that the expression of sine oculis homeobox homolog 1 (SIX1) varied among different subtypes of breast cancer and that it upregulated breast cancer grading and lymph node metastasis.
[Journal of Translational Medicine]
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Loss- and gain-of-function experiments were utilized to assess the biological effects of METTL3 and SOCS3 on the proliferation and stemness phenotypes in vitro and in vivo.
[Cancer Gene Therapy]
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Scientists examined how elevated extracellular periostin, as they found was present in recurrent ovarian cancer (OC), impacted OC cell functions and phenotypes, including stemness.
[Scientific Reports]
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Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cells from NF1 were isolated and cultured using fluorescence-activated cell sorting and colony formation experiments.
[Translational Oncology]
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The authors highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix, stromal cells, cancer-associated fibroblasts, mesenchymal stem cells, and physiological changes.
[Cancer Cell International]
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AbbVie announced that the company will pay $10 billion to the biotech firm Immunogen for the acquirement of an approved treatment for ovarian cancer and buying into a burgeoning area of oncology.
[STAT]
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February 14 – 18, 2024
Cancun, Mexico
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Albert Einstein College of Medicine – Bronx, New York, United States
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Jinfeng Labs & Institute of Functional Genomics – Chongqing, China
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Westlake University – Zhejiang, China
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Swammerdam Institute for Life Sciences – Amsterdam, Netherlands
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Babraham Institute – Cambridge, England, United Kingdom
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