 | | Vol. 14.10 – 4 June, 2025 |
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| Scientists developed a manganese-coordination driven glutamine and cancer stemness dual-tailored nano-herb for high-efficiency activation of dendritic cells.
[Biomaterials] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| Researchers validated the critical role of the histone methyltransferase SET and MYND domain-containing 3 (SMYD3) in the maintenance of leukemia stem cells in chronic myeloid leukemia.
[Cancer Research] |
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| Investigators showed that complete loss of Cdx1 or concurrent loss of Cdx1/2 increase the stemness and malignancy of intestinal tumors.
[Cell Death & Disease] |
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| Scientists investigated DAZ-associated protein 1’s (DAZAP1’s) impact on gastric cancer stemness and its mechanisms. DAZAP1 promotes tumor progression in gastric cancer stem cells, as shown by sphere formation assays and stemness marker analysis.
[JCI Insight] |
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| Investigators identified a novel long non-coding RNA NEAT1 in cancer-associated fibroblast-derived extracellular vesicles that plays a critical role in the induction of CSCs and hepatocellular carcinoma tumorigenesis.
[Cell Communication and Signaling] |
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| Researchers demonstrated that Sohlh1 functions through the SFRP1/Wnt/β-catenin signaling pathway and leads to the consequent suppression of glioma stem-like cells (GSLC) stemness and the promotion of GSLC differentiation in vitro and in vivo.
[Journal of Cellular and Molecular Medicine] |
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| IL-33 overexpression enhances proliferation, migration, and CSC marker expression in 4T1 and MDA-MB-231 cells, whereas ST2 knockdown via CRISPR or adeno-associated virus attenuates tumor growth and metastasis in vivo, reducing CSC frequency.
[Scientific Reports] |
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| Researchers explored the role of the vascular endothelial growth factor (VEGF) a/VEGF receptor 2 (VEGFR2) autocrine pathway in cinobufagin-induced inhibition of hepatocellular carcinoma metastasis.
[Discover Oncology] |
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| An RNA-sequencing data-based combined analysis of somatic mutations and gene expression was performed to explore the role of CSCs in disease progression using the novel Indian-origin Gingivobuccal oral squamous cell carcinoma cell line ‘IIOC019’ from a patient with tobacco-chewing habit.
[Computational Biology and Chemistry] |
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| CSC-derived exosomal transforming growth factor-β is a key driver of cancer-associated fibroblasts and type 2 macrophage polarization, with the latter mediated through activation of signal transducer and activator of transcription 3.
[Medical Oncology] |
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| Avenzo Therapeutics, Inc.announced initiation of a Phase I/II clinical study of its potential best-in-class EGFR/HER3 bispecific antibody-drug conjugate, AVZO-1418, in patients with advanced solid tumors.
[Avenzo Therapeutics, Inc.] |
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| July 2-5, 2025
Barcelona, Spain |
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| | University of Macau – Macau, China |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Indiana University – Bloomington, Indiana, United States |
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| | Erasmus University Medical Center – Rottterdam, Netherland |
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| | City of Hope – Monrovia, California, United States |
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Cancer Stem Cell News
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