 | | Vol. 10.17 – 22 July, 2024 |
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| Investigators reported an unexpected effect of keratin isoform variation on kinase signal transduction. Increased expression of wound-associated keratin 6A, but not of steady-state keratin 5, potentiated keratinocyte migration and wound closure without compromising mechanical stability.
[Developmental Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists reported an unexpected role of adult zebrafish appendages (fins) in accelerating the re-epithelialization process. Through whole-body monitoring of single-cell dynamics in live animals, they found that fin-resident epithelial cells were highly mobile and migrated to cover wounds in nearby body regions.
[Current Biology] |
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| By employing mouse psoriasis and skin organoid models, investigators discovered a mechano-chemical signaling pathway that originated from dendritic cells, extended to dermal fibroblasts, and ultimately enhanced basal cell proliferation in psoriatic skin.
[Cell Reports] |
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| Researchers uncovered a novel form of Golgi-lysosome cross-talk and its role in maintaining specialized secretory lysosomes in differentiated keratinocytes.
[Cell Death & Disease] |
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| Scientists discovered that reduced lamin A levels significantly induced nuclear influx of argonaute (AGO) 2 in SHSY5Y neuroblastoma and A375 melanoma cancer cell lines, which normally have no nuclear AGO2.
[Nucleic Acids Research] |
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| Investigators reported that the clinically relevant combination of MAP kinase pathway inhibitors Dabrafenib and Trametinib synergized with RIG-I agonist-induced immunotherapy to kill BRAF-mutated human and mouse melanoma cells.
[Molecular Therapy – Nucleic Acids] |
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| The authors discuss the determinants of melanoma tumor heterogeneity, mechanisms of therapy resistance, and effective therapy regimens that hold curative promise.
[Nature Cancer] |
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| Scientists review the most recent advances in the design and applications of skin-on-a-chip platforms (SoC) for disease modeling as well as the analysis of drugs and cosmetics. They also identify the existing obstacles that hinder the advancement of SoC platforms, proposing directions for future improvements.
[Biofabrication] |
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| NCInnovation announced the approval of $5.2 million in research funding for eight research projects at seven North Carolina public universities. Projects recently approved include multi-year vaccine development, neuro drug delivery system, and melanoma research.
[Dermatology Times] |
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| August 19 – 21, 2024
San Diego, California, United States |
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| | University of Nottingham – Nottingham, England, United Kingdom |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | Goethe University Frankfurt am Main – Frankfurt, Germany |
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| | Northwestern University – Chicago, Illinois, United States |
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| | KU Leuven – Leuven, Belgium |
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