 | | Vol. 10.21 – 25 November, 2024 |
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| Focusing on psoriasis as a disease model, investigators used high-resolution mass spectrometry imaging and identified keratin 14-expressing keratinocytes executing a ferroptotic death program in human psoriatic skin.
[Journal of Clinical Investigation] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| The authors highlighted the role of the protein tyrosine kinase 2 (PTK2)-itchy E3 ubiquitin protein ligase (ITCH)-melan-A (MLANA)-optineurin (OPTN) cascade in orchestrating melanophagy progression.
[Autophagy] |
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| Transgenic mouse experiments confirmed that integrin beta-like 1 (Itgbl1)-expressing fibroblasts were required for granulation tissue formation and drove fibrogenesis during skin repair. Scientists detected a minority population of Acta2high-expressing myofibroblasts with apparent involvement in scarring.
[EMBO Reports] |
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| Researchers leveraged 3D bioprinting technology to fabricate a full-thickness human skin equivalent with hypodermis. The collagen hydrogel-based structure provided a mimetic environment for skin cells to adhere, proliferate, and differentiate.
[Communications Biology] |
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| Scientists focused on treatment responses of 3D skin replicas. Cytokine-priming of skin organoids induced psoriatic features like inflammation, antimicrobial peptides, hyperproliferation, and impaired differentiation.
[Communications Biology] |
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| This Phase Ib trial study assessed the efficacy and safety of the combination of neoadjuvant oncolytic virus orienX010 (ori) and anti-PD-1 toripalimab (tori) for resectable acral melanoma (AM). Neoadjuvant ori and tori demonstrated antitumor activity with high response rates for AM with acceptable tolerability.
[Signal Transduction and Targeted Therapy] |
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| Atypical telomerase reverse transcriptase promoter (TERTp) mutations occured with canonical driver mutations in large cancer cohorts and arose subclonally specifically on the TERTp driver mutant chromosome homolog of melanoma cells treated with UV light in vitro.
[Nature Communications] |
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| Researchers showed that the small hydrolyze guanosine triphosphate Rab7a strongly enhanced the activity of TPC2 and that effects of TPC2 on melanoma hallmarks, in vitro and in vivo strongly depended on the presence of Rab7a.
[Nature Communications] |
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| Scientists reported that acetyl-CoA synthetases (ACSS) 1 and 2 were differentially expressed in cancer. ACSS1 knockdown decreased acute myeloid leukemia burden (AML) in vivo and inhibited melanoma tumor and metastatic growth.
[Cell Reports] |
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| Investigators found that Myc-associated zinc-finger protein (MAZ) could target and regulate the transcription of NADH dehydrogenase iron-sulfur protein 3 (NDUFS3), a core subunit of mitochondrial complex I, to enhance mitochondrial metabolism and thus promote malignant progression of melanoma.
[Communications Biology] |
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| The use of fibroblasts and keratinocytes as cell therapy has shown promise in skin disorders such as epidermolysis bullosa. Future efforts include testing the ability of fibroblasts to reprogram nonvolar to volar skin to reduce stump dermatoses in patients with limb loss using prosthetics.
[Journal of Investigative Dermatology] |
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| The authors examine the multifaceted implication of the cGAS-STING pathway in melanoma pathogenesis and treatment. They explore its molecular mechanisms, including epigenetic regulation and interaction with signaling pathways such as androgen receptor signaling.
[Cell Communication and Signaling] |
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| Sanofi, the Agency for Science, Technology and Research (A*STAR), and the National Skin Centre Singapore established a Memorandum of Understanding to advance research in acne treatment. This collaboration will encompass a Phase I clinical study in patients with mild acne.
[A*STAR] |
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| Irish research into new bandaging aims to ease the agony experienced by those living with genetic skin condition epidermolysis bullosa. Scientists are leading research into whether “spray on, wash off” bandages will be a viable alternative to those currently used.
[Maynooth University] |
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| A visionary gift from Pamela Galli AO will sustain and advance research into neurodevelopmental disorders, skin cancer prevention and treatments, as well as enabling new areas of investigation and research collaboration.
[University of Melbourne] |
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| | Dallas, Texas, United States |
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| | Spanish National Cancer Research Center – Madrid, Spain |
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| | Northwell Health – Manhasset, New York, United States |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | University of Wisconsin Madison – Madison, Wisconsin, United States |
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