 | | Vol. 11.02 – 10 February, 2025 |
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| Scientists reported that selectively silencing the ribosomal protein S6 kinase (S6K) 2 while preserving the activity of S6K1 perturbed lipid metabolism and triggerd lethal lipid peroxidation in NRASMUT melanoma cells that were resistant to MAPK inhibition.
[Science Translational Medicine] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers developed a highly efficient and versatile gene editing strategy for recessive dystrophic epidermolysis bullosa that incorporated the small molecule inhibitor M3814 to enhance homology-directed repair (HDR).
[Molecular Therapy – Nucleic Acids] |
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| The authors identified a stem cell–specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisions in skin epidermis. CerS4 prevented the proper development of the adult hair follicle bulge stem cell compartment due to altered differentiation trajectories.
[Journal of Cell Biology] |
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| Researchers showed that Zika virus immediately altered gene/protein expression patterns in infected-dermal fibroblasts, altering their metabolism to increase the release of mosquito-attractive volatile organic compounds, which improved its transmission success.
[Communications Biology] |
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| Using CD4 knockout mice, scientists demonstrated that CD4 expression was essential for maintaining fast-cycling epidermal stem cells during homeostasis and that CD4 loss mitigated the age-related decline in wound repair capacity.
[Scientific Reports] |
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| Utilizing mouse models that mimic human melanoma brain metastases, researchers investigated the necessity of focal adhesion kinase in the development of distant metastases and its potential as a therapeutic target.
[Cell Reports Medicine] |
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| The authors identified a robust poly ADP ribosyl polymerase 14 (PARP14) catalytic inhibitor gene signature and evaluated its association with patient survival.
[Journal for Immunotherapy of Cancer] |
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| To identify tumor-intrinsic modulators of immunity to melanoma, investigators performed a whole-genome CRISPR screen in melanoma and identified Setdb1 as well as all components of the human silencing hub complex.
[Cancer Immunology Research] |
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| Scientists revealed that poly (ADP-ribose) polymerase 4 (PARP4) played a role in double-strand break repair by regulating the non-homologous end joining pathway through its involvement in Ku80 mono-ADP-ribosylation.
[Cell Death Discovery] |
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| Given the unique roles and significant contributions of various cell types involved in the process of psoriasis, a thorough analysis of specific epigenetic patterns in different cell types becomes a key entry point for elucidating the mechanisms of disease development.
[Clinical Reviews In Allergy & Immunology] |
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| The authors summarize the connection between mitochondrial dysfunction and hair follicle development, outline the links between diseases related to mitochondrial disorders and hair issues, and highlight the influence of mitochondrial dysfunction on androgenetic alopecia.
[Stem Cell Research & Therapy] |
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| Metabolic pathways, together with receptor- and nonreceptor-mediated phenotypic activities of its intermediates, have been identified as a cutaneous melatoninergic system. Pharmacological modulation of melatonin or its metabolites may be used to treat cutaneous disorders and aging.
[Journal of Investigative Dermatology] |
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| Dermata Therapeutics, Inc. announced issuance by the US Patent and Trademark Office of a new patent for its XYNGARI™ product candidate for the treatment of acne.
[Dermata Therapeutics, Inc. (BioSpace)] |
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| March 18-19, 2025
London, England, United Kingdom |
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| | UConn Health – Farmington, Connecticut, United States |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Stony Brook University – Stony Brook, New York, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | The University of Arizona – Tucson, Arizona, United States |
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