Dermal Cell News Volume 6.29 | Aug 17 2020

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    DCN 6.29 | Aug 17


    Dermal Cell News by STEMCELL Technologies
    Vol. 6.29 – 17 August, 2020
    TOP STORY

    Disease-Associated KIF3A Variants Alter Gene Methylation and Expression Impacting Skin Barrier and Atopic Dermatitis Risk

    Researchers found that KIF3A SNP rs11740584 and rs2299007 risk alleles created cytosine-phosphate-guanine sites, which were highly methylated and resulted in lower KIF3A expression.
    [Nature Communications]

    Full Article

    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    PUBLICATIONSRanked by the impact factor of the journal

    Proenkephalin+ Regulatory T Cells Expanded by Ultraviolet B Exposure Maintain Skin Homeostasis with a Healing Function

    Scientists found that skin Treg cells possessing a healing function were expanded by UVB exposure with the expression of an endogenous opioid precursor, proenkephalin.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Keratinocyte-Specific Peptides-Based Surfaces for Hemidesmosome Upregulation and Prevention of Bacterial Colonization

    The co-immobilized peptide surfaces showed anti-biofilm activity against Streptococcus gordonii while enhancing proliferation, hemidesmosome formation, and mechanical attachment of orally-derived keratinocytes.
    [ACS Biomaterials Science & Engineering]

    Abstract

    Selective Antibiofilm Properties and Biocompatibility of Nano-ZnO and Nano-ZnO/Ag Coated Surfaces

    Researchers demonstrated that surfaces coated with nano-ZnO or nano-ZnO/Ag composites were not cytotoxic to human keratinocytes and possessed species-selective medium-dependent antibiofilm activity against Escherichia coli, Staphylococcus aureus and Candida albicans.
    [Scientific Reports]

    Full Article

    Inhibition of Wnt Signaling Pathway Suppresses Radiation-Induced Dermal Fibrosis

    Radiation with a single dose of 2 Gy not only facilitated fibrosis in cultured human dermal fibroblasts via activation of the Wnt/β-catenin pathway but also initiated EMT in cultured keratinocytes, developing collagen-producing mesenchymal cells.
    [Scientific Reports]

    Full Article

    Costello Syndrome Model Mice with a Hras G12S Mutation Are Susceptible to Develop House Dust Mite-Induced Atopic Dermatitis

    Cultured HrasG12S/+ keratinocytes exhibited increased IL-33 expression after Dermatophagoides farinae stimulation.
    [Cell Death & Disease]

    Full Article

    Usefulness of 2D Shear Wave Elastography for the Diagnosis of Inguinal Lymph Node Metastasis of Malignant Melanoma and Squamous Cell Carcinoma

    Scientists determined the presence or absence of metastatic lymphadenopathy in the inguinal lymph nodes of five patients with malignant melanoma and squamous cell carcinoma.
    [Journal of Dermatology]

    Full Article

    Ursolic Acid Inhibits Pigmentation by Increasing Melanosomal Autophagy in B16F1 Cells

    Researchers showed that ursolic acid inhibited skin pigmentation by promoting melanosomal autophagy, or melanophagy, in melanocytes.
    [Biochemical and Biophysical Research Communications]

    Abstract

    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    CD146, from a Melanoma Cell Adhesion Molecule to a Signaling Receptor

    Overexpression of CD146 can be observed in most of malignancies and is implicated in nearly every step of the development and progression of cancers, especially vascular and lymphatic metastasis.
    [Signal Transduction and Targeted Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    RenovaCare Receives FDA Conditional IDE Approval of CellMistâ„¢ System and SkinGunâ„¢ Device, Enabling Clinical Study for Safety and Feasibility

    RenovaCare, Inc. has announced that the US FDA conditionally approved the company’s Investigational Device Exemption application to conduct a clinical trial to evaluate the safety and feasibility of autologous stem cells rendered by its CellMist™ System from donor skin and applied topically with the SkinGun™ spray device for treatment of burn wounds.
    [RenovaCare, Inc.]

    Press Release

    FEATURED EVENT

    NCRI 2020: Virtual Showcase

    November 2 – November 3
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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Translational Cancer

    University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States

    Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    Postdoctoral Positions – Cancer Genomics/Computational Biology

    Stanford Institute for Stem Cell Biology and Regenerative Medicine – Stanford, California, United States

    Postdoctoral Fellow – Immune and Stem Cell Engineering

    Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

    Postdoctoral Fellow – Novel Melanoma Therapies

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    > See All Jobs

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