Dermal Cell News Volume 7.06 | Feb 22 2021

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    Justin.choi
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    2021-02-22 | DCN 7.06


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.06 – 22 February, 2021
    TOP STORY

    Injectable Hydrogels of Newly Designed Brush Biopolymers as Sustained Drug-Delivery Vehicle for Melanoma Treatment

    Cellular studies indicated the biocompatible nature of the brush copolymers whose controlled and slow release of drug exhibited significant cytotoxic effects on cancer cells.
    [Signal Transduction and Targeted Therapy]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Polycomb Complexes Redundantly Maintain Epidermal Stem Cell Identity during Development

    Researchers showed how polycomb repressive complex 1 (PRC1) and PRC2 function as two independent counterparts, thereby providing a repressive safety net that protects and preserves lineage identity.
    [Genes & Development]

    AbstractPress Release

    Improved Diabetic Wound Healing by Bovine Lactoferricin Is Associated with Relevant Changes in the Skin Immune Response and Microbiota

    The wound healing potential of bovine lactoferricin was investigated using in vitro, ex vivo, and in vivo models. Cell migration and proliferation were tested on keratinocytes and on porcine ears.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Spermidine-Induced Recovery of Human Dermal Structure and Barrier Function by Skin Microbiome

    Treatment with secretions of S. pneumoniae and S. infantis induced the expression of genes associated with the formation of skin structure and the skin barrier function in human skin cells.
    [Communications Biology]

    Full Article

    G9a Inhibition Enhances Checkpoint Inhibitor Blockade Response in Melanoma

    Investigators demonstrated G9a histone methyltransferase inhibition was able to not only robustly induce LC3B level to augment the efficacy of checkpoint inhibitor blockade, but also induced melanoma cell death.
    [Clinical Cancer Research]

    Abstract

    Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment

    Researchers hypothesized ICI resistance mutations in the IFNγ pathway would simultaneously render melanomas susceptible to oncolytic virus therapy.
    [Clinical Cancer Research]

    Abstract

    USP22 Deficiency in Melanoma Mediates Resistance to T-Cell through IFNγ-JAK1-STAT1 Signal Axis

    Scientists perturbed genes in melanoma cells to screen for genes involved in tumor escape from T cell-mediated killing. Multiple interferon gamma (IFNγ) signaling related genes were enriched in melanoma cells resistant to T-cell killing.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Autophagy Buffers Ras-Induced Genotoxic Stress Enabling Malignant Transformation in Keratinocytes Primed by Human Papillomavirus

    Investigators showed that highly transforming mitogenic signals triggered by HRasG12V activity in E6E7–HPV–keratinocytes generated strong replication and oxidative stresses.
    [Cell Death & Disease]

    Full Article

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    REVIEWS

    Functional Hair Follicle Regeneration: An Updated Review

    Scientists review potential cell sources with hair follicle (HF)-inducive capacities and summarize current bioengineering strategies for HF regeneration with functional restoration.
    [Signal Transduction and Targeted Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    Dutch Consortium Investigates Biomarker to Identify Early-Stage Melanoma at High-Risk of Recurrence

    SkylineDx announced a research collaboration with an academic hospital and a Dutch cancer registry to investigate patients with early-stage melanoma at high risk of disease-related fatality.
    [SkylineDx, Inc.]

    Press Release

    FEATURED EVENT

    10th International Meeting of the Stem Cell Network

    March 29 – 30, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Signaling Pathways and Melanoma

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    Postdoctoral Scholar – Immune Responses in Human Skin and Mucosal Surfaces

    University of Washington – Seattle, Washington, United States

    Research Assistant – Melanoma Research

    Portland VA Research Foundation – Portland, Oregon, United States

    Postdoctoral Studies – Skin Cell Biology

    Karolinska Institutet – Stockholm, Sweden

    Postdoctoral Position – Wound Healing and Regulatory RNA

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

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