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Pulmonary Cell News| Endothelial Cell News 3.27 August 13, 2018 | |
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TOP STORYUCLA Researchers Discover How the Body Regenerates Blood Vessel Lining Normal wear and tear damages the endothelial lining. The body, however, has the ability to initiate molecular activity that regenerates and repairs this damage. Researchers have for the first time followed this regeneration in progress and identified the genes and proteins responsible for spurring it. [Press release from the University of California, Los Angeles discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors performed droplet-based single-cell RNA sequencing (scRNA-seq) on human induced pluripotent stem cells (iPSCs) after iPSC-endothelial cell differentiation. Droplet-based scRNA-seq enabled analysis of thousands of cells in parallel, allowing comprehensive analysis of transcriptional heterogeneity. [Circ Res] Full Article Microfabrication of Angiochip, a Biodegradable Polymer Scaffold with Microfluidic Vasculature Scientists provided a detailed protocol for fabricating the AngioChip scaffold, populating it with endothelial cells and parenchymal tissues, and applying it in organ-on-a-chip drug testing in vitro and surgical vascular anastomosis in vivo. [Nat Protoc] Abstract EGFL7 Enhances Surface Expression of Integrin α5β1 to Promote Angiogenesis in Malignant Brain Tumors Epidermal growth factor‐like protein 7 (EGFL7) expression promoted glioma growth in experimental glioma models in vivo and stimulated tumor vascularization. Mechanistically, this was mediated by an upregulation of integrin α5β1 on the cellular surface of endothelial cells, which enhanced fibronectin‐induced angiogenic sprouting. [EMBO Mol Med] Full Article | Graphical Abstract Researchers report a method for the scalable manufacturing of endothelial cells (ECs) from human pluripotent stem cells (hPSCs). hPSCs were expanded and differentiated into ECs in a 3D thermoreversible PNIPAAm-PEG hydrogel. [Stem Cell Reports] Full Article | Graphical Abstract The authors demonstrated that exosomes delivered miR-130a from gastric cancer cells into vascular cells to promote angiogenesis and tumor growth by targeting c-MYB both in vivo and in vitro. [Mol Ther] Abstract Scientists investigated whether mesenchymal stem cells (MSCs) could ameliorate high-glucose-induced endothelial injury through the modulation of mitophagy. They observed that exposure of HUVECs to high glucose triggered mitochondrial impairment with excessive mitochondrial fragmentation and ROS generation, loss of membrane potential and reduced ATP production. [Cell Death Dis] Full Article The fabricated corneal endothelium with cultured human corneal endothelial cells easily survived and functioned as corneal endothelium in vivo. [Adv Healthc Mater] Abstract Tigecycline effectively inhibited angiogenesis through suppressing capillary network formation, migration, proliferation and survival of human retinal microvascular endothelial cells. [Sci Rep] Full Article Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival Investigators found that vasoactive intestinal peptide significantly accelerated endothelial wound closure and suppressed interferon-γ– and tumor necrosis factor-α–induced corneal endothelial cells apoptosis in vitro in a dose-dependent manner. [Am J Pathol] Full Article | Press Release Overexpression of steroid receptor coactivator (SRC)-1 and SRC-3 in high glucose-treated endothelial cells significantly increased cell viability, suspended cell senescence, and inhibited cell apoptosis compared with control cells. [Acta Pharmacol Sin] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSRegulation of Tumor Angiogenesis by MicroRNAs: State of the Art Several miRNAs have been identified that affect different targets in the tumor angiogenesis pathway. Most of these miRNAs affect VEGF and its tyrosine kinase receptors expression downstream of the hypoxia‐inducible factor 1. The authors focus on tumor angiogenesis regulation by miRNAs and the mechanism underlying this regulation. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSRegeneron Pharmaceuticals, Inc. announced that due to ongoing labeling discussions the FDA has issued a complete response letter regarding the supplemental Biologics License Application (sBLA) for EYLEA® injection in patients with wet age-related macular degeneration. [Regeneron Pharmaceuticals, Inc.] Press Release Eisai Co., Ltd. and Merck & Co., Inc. announced that the FDA granted Breakthrough Therapy designation for LENVIMA®, in combination with Merck & Co., Inc.’s anti-PD-1 therapy KEYTRUDA® for the potential treatment of patients with advanced and/or metastatic non-microsatellite instability high/proficient mismatch repair endometrial carcinoma who have progressed following at least one prior systemic therapy. [Eisai Co., Ltd.] Press Release Xcovery announced that the first cohort of patients has been enrolled to the Phase I/II clinical trial evaluating the safety and efficacy of the combination of vorolanib and nivolumab for the treatment of non-small cell lung cancer or thymic carcinoma. [Xcovery (Business Wire Inc.)] Press Release | |
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POLICY NEWSGene-Silencing Technology Gets First Drug Approval after 20-Year Wait US regulators have approved the first therapy based on RNA interference, a technique that can be used to silence specific genes linked to disease. The drug, patisiran, targets a rare condition that can impair heart and nerve function. [Nature News] Editorial US Congress Leaves Science Agencies Hanging — Again Lawmakers in the US Congress are running out of time to pass a budget for the 2019 fiscal year, and have yet to resolve major disagreements over climate-change and environment programs. [Nature News] Editorial Gottlieb: FDA Will Streamline Drug Safety Evaluations The FDA will soon standardize the way it handles data on the safety and effectiveness of drugs in an effort to reduce inconsistencies in the drug review process. [STAT News] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) 2019 Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Lymph Node Vasculature (Uppsala University) NEW Postdoctoral Fellow – Pulmonary Arterial Hypertension (National Institutes of Health) NEW Postdoctoral Fellow – Tumor and Autoimmune Pathogenesis (Stanford University) NEW Scientist – Cardiovascular Research (University of Iowa Hospital and Clinics) NEW Senior Postdoctoral Research Position – Cardiovascular Research (University of Tennessee) Research Scientist – Corneal Cells (The Veneto Eye Bank Foundation) Postdoctoral Research Assistant – Cancer and Vascular Biology (University of Oxford) Postdoctoral Fellow – Cardiovascular Stem Cell Biology (University of Illinois at Chicago) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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