|
| The authors proposed that FMNL2 regulated pathology-dependent plasticity of the blood-brain-barrier by controlling gliovascular interactions and stimulating the clearance of extracellular aggregates.
[Acta Neuropathologica] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists examined the potential biological function of phosphoenolpyruvate carboxykinase 1 (PCK1) in angiogenesis. Short hairpin RNA- or CRISPR-Cas9–induced PCK1 depletion potently inhibited endothelial cell proliferation, migration, sprouting, and tube formation, whereas ectopic PCK1 overexpression exerted opposite activity.
[Science Advances] |
|
|
|
| Researchers demonstrated the role of VEGF, a key mediator of vascular angiogenesis and blood-brain barrier (BBB) permeability, in stress-induced BBB dysfunction and depressive-like behavior development.
[Molecular Psychiatry] |
|
|
|
| The authors showed that unconfined endothelial cell monolayers on microgroove substrates that mimicked the anisotropic organization of the extracellular matrix exhibited a specific type of collective movement that took the form of a periodic pattern of antiparallel cell streams.
[Nature Communications] |
|
|
|
| Investigators showed that extracellular vimentin contributed to immune suppression and functioned as a vascular immune checkpoint molecule.
[Nature Communications] |
|
|
|
| The glioblastoma-associated microglia M2 polarization was constructed, and microglia-derived exosomes were isolated to co-culture with human brain microvessel endothelial cells.
[Oncogene] |
|
|
|
| Scientists reported that miRNA-188-3p expression was upregulated in skeletal endothelium and negatively regulated the formation of type H vessels during aging.
[Cell Death & Disease] |
|
|
|
| Investigators ablated Notch1 in keratocytes using Twist2-Cre mice and found that Twist2-Cre; Notch1f/f mice developed stroma expansion and neovascularization, followed by hyperproliferation and metaplasia of corneal epithelial progenitor cells and plaque formation at central cornea, leading to loss of transparency.
[Stem Cell Reports] |
|
|
|
| Researchers established trastuzumab-resistant cells and patient-derived gastric cancer xenografts models to measure metabolic levels and vascular density and shape.
[British Journal of Cancer] |
|
|
|
| The authors demonstrated that H3 receptor (H3R) antagonism promoted angiogenesis after cerebral ischemia, which was independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2.
[Acta Pharmacologica Sinica] |
|
|
|
| Scientists investigated the patterns of endothelial wall shear stress (ESS) across coronary lesions from non-invasive imaging with coronary computed tomography angiography and defined plaque-associated ESS values in patients with coronary artery disease.
[European Heart Journal-Cardiovascular Imaging] |
|
|
|
| In vitro studies using human retinal microvascular endothelial cells showed that IL-33 induced sprouting angiogenesis and required NFκB-mediated Jagged1 expression and Notch1 activation.
[Communications Biology] |
|
|
|
| Researchers developed an integrated process for simultaneous isolation and culture of the main cell types comprising the microcirculation in adult mouse heart: endothelial cells, pericytes, and vascular smooth muscle cells.
[Scientific Reports] |
|
|
|
|
| The authors review the molecular mechanisms that mediate cell death and its implications for atherosclerosis and vascular calcification.
[Cell Death & Disease] |
|
|
|
|
| Elevar Therapeutics, Inc. announced its Phase II clinical trial evaluating rivoceranib, an orally administered tyrosine kinase inhibitor, demonstrated clinical effectiveness in patients with progressive recurrent or metastatic adenoid cystic carcinoma.
[Elevar Therapeutics, Inc.] |
|
|
|
| Dr. Yeoheung Yun, the creator of a mini-brain model used to study Alzheimer’s disease, was announced the winner of the 2022 O. Max Gardner Award, the most prestigious annual prize for faculty awarded by the 17-campus University of North Carolina System.
[North Carolina Agricultural and Technical State University] |
|
|
|
|
| September 7 – 11, 2022
Woods Hole, Massachusetts, United States |
|
|
|
|
|
| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
|
|
|
|
| | UC Davis – Davis, California, United States |
|
|
|
| | Flanders Institute for Biotechnology (VIB) – Leuven, Belgium |
|
|
|
| Johns Hopkins University School of Medicine – St. Petersburg, Florida, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
