 | | Vol. 17.31 – 10 August, 2022 |
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| Coupling a stroma-free T cell differentiation system with EZH1-knockdown-mediated epigenetic reprogramming, the authors generated iPSC-derived T cells which displayed a highly diverse T cell receptor repertoire and mature molecular signatures similar to those of TCRαβ T cells from peripheral blood.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the premature expression of the T cell receptor (TCR) or a constitutively expressed chimeric antigen receptor (CAR) in T cell-derived iPSCs promoted the acquisition of an innate phenotype, which could be averted by disabling the TCR and relying on the CAR to drive differentiation.
[Nature Biomedical Engineering] |
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| Scientists reported that PCGF6 controlled neuroectoderm specification of hPSCs by activating the SOX2 gene.
[Nature Communications] |
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| To understand which cell types and pathways are more directly affected by trisomy 21 (T21), the authors used an inducible-XIST system to silence one chromosome 21 in vitro. T21 caused the dysregulation of Notch signaling in iPSCs, potentially affecting cell-type programming.
[Cell Reports] |
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| Amphiphilic chitosan oligosaccharide-cholesterol copolymers were synthesized by varying cholesterol content and self-assembled into spherical micelle in a microfluidic chip with different flow rates.
[Biomaterials Advances] |
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| Researchers used hiPSCs generated from normal and genetically obese subjects and differentiated them into hepatocytes in cell culture. They showed that hepatocytes from obese iPSCs stored more lipids and showed increased cell death than normal iPSCs.
[Cell Death & Disease] |
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| Scientists demonstrated that Mettl14, another component of the methyltransferase complex, could significantly enhance the generation of iPSCs in an m6A-independent manner.
[Stem Cell Reports] |
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| Targeting NEUROG2 (NGN2) and TUBB3 as markers of neurogenic cells and neurons, respectively, the authors established TUBB3EGFP/NGN2TagRFP dual-reporter hiPSCs using CRISPR-Cas9 technology.
[Stem Cell Reports] |
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| Investigators estimated the genetic concordance between trophectoderm, inner cell mass, and the corresponding hESCs, and explored the characteristics of mosaicism in human blastocyst and hESCs on a single cell level.
[PLoS Genetics] |
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| The authors reprogrammed cynomolgus monkey kidney fibroblasts as a control for animal iPSCs and studied autologous transplants.
[Stem Cell Research] |
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| Researchers elucidated the genome-wide landscape of RNA:DNA hybrid structures called “R-loops” in primary neural stem/progenitor cells undergoing aphidicolin-induced, mild replication stress to assess the potential contribution of R-loops to the different, recurrent classes of DNA break “hotspots”.
[Scientific Reports] |
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| The authors describe new applications for generating emerging niches from hPSCs using developmental principles and highlight potential applications for regeneration and therapeutics.
[Trends in Cell Biology] |
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| Scientists provide an update on recent clinical applications using either hPSCs or mesenchymal stem cells derived from bone marrow, adipose tissue, or the umbilical cord for the treatment of human diseases.
[Signal Transduction and Targeted Therapy] |
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| Investigators discuss the early development of the cornea because protocols differentiating iPSCs toward corneal lineages rely heavily upon recapitulating this development.
[Stem Cell Reviews and Reports] |
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| Biomedical scientists using ESCs or fetal tissue could find their studies at risk in conservative states aiming to redefine personhood after the US Supreme Court’s rollback of abortion rights.
[Bloomberg Law] |
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| Turn Biotechnologies, a cell rejuvenation company developing novel mRNA medicines to cure untreatable, age-related conditions, announced that Co-Founder Dr. Vittorio Sebastiano will become its head of research.
[Turn Biotechnologies (Cision US, Inc.)] |
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| October 17 – October 20, 2022
Palermo, Italy |
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| | University of Calgary – Calgary, Alberta, Canada |
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| | Yale University – New Haven, Connecticut, United States |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | AstraZeneca – Cambridge, England, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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