 | | Vol. 13.18 – 12 May, 2022 |
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Reciprocal Cell-ECM Dynamics Generate Supracellular Fluidity Underlying Spontaneous Follicle Patterning | Scientists found that contractile cells physically rearranged the ECM and that ECM rearrangement further aligned
cells.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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Klotho in Osx+-Mesenchymal Progenitors Exerts Pro-Osteogenic and Anti-Inflammatory Effects during Mandibular Alveolar Bone Formation and Repair | Researchers identified the mechanism whereby Klotho expressed in Osx+-mensenchymal progenitors controlled
osteoblast differentiation and osteoclastogenesis during mandibular alveolar bone formation and repair.
[Signal Transduction and Targeted Therapy] |
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Autophagic LC3+ Calcified Extracellular Vesicles Initiate Cartilage Calcification in Osteoarthritis | Investigators demonstrated that pathological cartilage calcification occurred in the early stage of osteoarthritis in
which the calcified extracellular vesicles were closely involved.
[Science Advances] |
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Intracellular Hydroxyproline Imprinting Following Resolution of Bleomycin-Induced Pulmonary Fibrosis | The authors followed the dynamic fibrotic features of bleomycin-treated mouse lungs over extended durations through a
combination of the latest technologies — micro-computed tomography imaging and histological detection of degraded collagens — and traditional methods.
[European Respiratory Journal] |
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An Instantly Fixable and Self-Adaptive Scaffold for Skull Regeneration by Autologous Stem Cell Recruitment and Angiogenesis | Scientists designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid chelating
Ca2+ of the microhydroxyapatite surface and bonding type I collagen to highly simulate the natural bony matrix.
[Nature Communications] |
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Single-Cell Profiling of Human Dura and Meningioma Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response | Researchers used single-cell RNA sequencing to perform the first characterization of both non-tumor-associated human dura
and primary meningioma samples.
[Genome Medicine] |
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Bacterial Matrix Metalloproteases and Serine Proteases Contribute to the Extra-Host Inactivation of Enteroviruses in Lake Water | The authors demonstrated the direct effect of bacterial proteases on the inactivation of enteroviruses and identified
matrix metalloproteases as effective controls on enteroviruses’ environmental persistence.
[ISME Journal] |
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A Pan-Cancer Metabolic Atlas of the Tumor Microenvironment | Researchers used a tumor transcriptome deconvolution approach to profile the metabolic states of cancer and non-cancer
cells in bulk tumors of 20 solid tumor types.
[Cell Reports] |
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Histone H3K9 Methyltransferase SETDB1 Augments Invadopodia Formation to Promote Tumor Metastasis | Investigators demonstrated that SETDB1 augmented the migration and invasion capabilities of non-small cell lung cancer
cells by reinforcing invadopodia formation and mediated ECM degradation.
[Oncogene] |
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The Transcription Factor PREP1 (PKNOX1) Regulates Nuclear Stiffness, the Expression of LINC Complex Proteins and Mechanotransduction | The authors showed that PKNOX1 regulated the stiffness of the nucleus, the expression of LINC complex proteins, and
mechanotransduction of YAP-TAZ.
[Communications Biology] |
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Radiobiological Effects of Wound Fluid on Breast Cancer Cell Lines and Human-Derived Tumor Spheroids in 2D and Microfluidic Culture | To clarify the effects of intraoperative radiotherapy-induced wound fluid on tumor progression, scientists treated breast
cancer cell lines and human-derived tumor spheroids in 2D and microfluidic cell culture systems, respectively.
[Scientific Reports] |
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Efficient Deformation Mechanisms Enable Invasive Cancer Cells to Migrate Faster in 3D Collagen Networks | Investigators used 3D time lapse imaging on a confocal microscope and a phase correlation method to follow fiber
deformations, as well as cell morphology and live actin distribution during the migration of cancer cells.
[Scientific Reports] |
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Microfluidics Meets 3D Cancer Cell Migration | The authors discuss recent developments in cancer cell migration and how microfluidic strategies have evolved to address
the physiological complexities of the tumor microenvironment to visualize migration modes adapted by various tumor cells.
[Trends in Cancer] |
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A Guide to the Organ-on-a-Chip | Scientists give an introduction to the aspects of organs-on-chips (OoCs) that need to be considered when developing an
application-specific OoC.
[Nature Reviews Methods Primers] |
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Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai Announce a Joint Center for Engineering and Precision Medicine in New York City | Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai announced the creation of the Center for
Engineering and Precision Medicine, one of the first centers in the nation to bridge engineering and engineering science with medicine.
[Rensselaer Polytechnic Institute] |
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| September 7 – 11, 2022
Woods Hole, Massachusetts, United States |
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| | Jülich Research Centre – Jülich, Germany |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | New York University College of Dentistry – New York, New York, United States |
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| | University of Manchester – Manchester, England, United Kingdom |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
