 | | Vol. 13.19 – 19 May, 2022 |
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A Basement Membrane Discovery Pipeline Uncovers Network Complexity, Regulators, and Human Disease Associations | By developing a bioinformatic and in vivo discovery pipeline, researchers defined a network of 222 human proteins and their animal orthologs localized to basement membranes.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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Topography-Induced Large-Scale Antiparallel Collective Migration in Vascular Endothelium | The authors showed that unconfined endothelial cell monolayers on microgroove substrates that mimic the anisotropic organization of the ECM exhibited a specific type of collective movement that took the form of a periodic pattern of antiparallel cell streams.
[Nature Communications] |
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Chemotherapy-Induced Collagen IV Drives Cancer Cell Motility through Activation of Src and Focal Adhesion Kinase | Scientists showed that decellularized ECM (dECM) obtained from chemotherapy-treated mice increased motility of treatment-naïve breast cancer cells compared with vehicle-treated dECM.
[Cancer Research] |
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Mast Cell Infiltration of the Choroid and Protease Release Are Early Events in Age-Related Macular Degeneration Associated with Genetic Risk at Both Chromosomes 1q32 and 10q26 | Investigators found that increased mast cell infiltration of the inner choroid, degranulation, and subsequent extracellular matrix remodeling were early events in age-related macular degeneration (AMD) pathogenesis and represented a unifying mechanistic link between chromosome (Chr)1- and Chr10-mediated AMD.
[Proceedings of the National Academy of Sciences of the United States of America] |
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Mussel-Inspired Multifunctional Surface through Promoting Osteogenesis and Inhibiting Osteoclastogenesis to Facilitate Bone Regeneration | Through a facile surface coating process, mussel-inspired polydopamine was adhered to the surface of a biocompatible porous scaffold followed by the immobilization of a small-molecule activator and the subsequent in situ coprecipitation of hydroxyapatite nanocrystals.
[npj Regenerative Medicine] |
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Synovial Mesenchymal Progenitor Derived Aggrecan Regulates Cartilage Homeostasis and Endogenous Repair Capacity | Using mice models of osteoarthritis (OA) and cartilage repair, the authors demonstrated that intra-articular injection of aggrecan into OA joints inhibited cartilage degeneration and stimulated cartilage repair respectively.
[Cell Death & Disease] |
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An Injectable Gelatin/Sericin Hydrogel Loaded with Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Uterine Injury | A methacrylate gelatin and methacrylate sericin hydrogel with human umbilical cord mesenchymal stem cells encapsulation was designed for facilitating endometrial regeneration and fertility restoration through in situ injection.
[Bioengineering & Translational Medicine] |
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New Approach to Prepare Cytocompatible 3D Scaffolds via the Combination of Sodium Hyaluronate and Colloidal Particles of Conductive Polymers | Scientists used a technique of scaffold preparation that overcame the limitations of conductive polymers and led to the preparation of cytocompatible scaffolds with potentially cell-instructive properties, which may be of advantage in the healing of damaged electro-sensitive tissues.
[Scientific Reports] |
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99mTc-NTP 15–5 Is a Companion Radiotracer for Assessing Joint Functional Response to Sprifermin (rhFGF-18) in a Murine Osteoarthritis Model | Researchers showed that articular cartilage could be quantitatively assessed in nuclear medicine imaging by their radiotracer 99mTc-NTP 15-5 targeting cartilage proteoglycans.
[Scientific Reports] |
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Laminin-Integrin a6b4 Interaction Activates Notch Signaling to Facilitate Bladder Cancer Development | A 2D collagen/laminin culture system was established and CCK-8/transwell assay was conducted to evaluate the proliferation/migration ability of Biu-87 and MB49 cells cultured on 2D gels.
[BMC Cancer] |
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ONOO−-Mediated Oxidative Modification of Extracellular Matrix Aggravates Atherosclerosis by Affecting Biological Behaviors of Vascular Smooth Muscle Cells | Investigators studied the effect of oxidizing agent peroxynitrite-mediated oxidization of ECM proteins on the biological behaviors of vascular smooth muscle cells and the development of atherosclerosis.
[Cell Biology International] |
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A Biomimetic High Throughput Model of Cancer Cell Spheroid Dissemination onto Aligned Fibrillar Collagen | Scientists implemented a spheroid-based migration assay, integrated with a fibrillar type I collagen matrix, in a manner compatible with high throughput image acquisition and quantitative analysis.
[Slas Technology] |
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Skeletal and Extraskeletal Disorders of Biomineralization | The authors discuss the current knowledge of biomineralization derived from basic and clinical research and point to future studies that will lead to new therapeutic approaches for biomineralization disorders.
[Nature Reviews Endocrinology] |
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Microfluidics Meets 3D Cancer Cell Migration | Investigators discuss developments in cancer cell migration and how microfluidic strategies have evolved to address the physiological complexities of the tumor microenvironment to visualize migration modes adapted by various tumor cells.
[Trends in Cancer] |
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The Alternative Matrisome: Alternative Splicing of ECM Proteins in Development, Homeostasis and Tumor Progression | Scientists address the complexity of the ECM by highlighting the importance of the yet-to-be-fully-characterized “alternative” matrisome in physiological and pathological states such as cancer.
[Matrix Biology] |
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Historic $200 Million Commitment to the University of Colorado Anschutz Medical Campus Fuels Advancements in Treatments and Cures | The University of Colorado Anschutz Medical Campus announced the creation of the Gates Institute, a state-of-the-art facility that will focus on rapidly translating laboratory findings into regenerative, cellular and gene therapies for patients.
[University of Colorado Anschutz Medical Campus] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Jülich Research Centre – Jülich, Germany |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | New York University College of Dentistry – New York, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
