Extracellular Matrix News Volume 13.30 | Aug 4 2022

    0
    23








    2022-08-04 | ECM 13.30


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.30 – 4 August, 2022
    TOP STORY

    Amphiphilic and Fatigue-Resistant Organohydrogels for Small-Diameter Vascular Grafts

    Amphiphilic and fatigue-resistant organohydrogels were fabricated via the click chemical reaction of unsaturated functional microbial polyhydroxyalkanoates and polyethylene glycol diacrylate and a combination of 2D material graphdiyne.
    [Science Advances]

    Full Article

    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    In Mouse Chronic Pancreatitis CD25+FOXP3+ Regulatory T Cells Control Pancreatic Fibrosis by Suppression of the Type 2 Immune Response

    The authors identified regulatory T cells as central regulators of the fibroinflammatory reaction by a selective depletion of FOXP3-positive cells in a transgenic mouse model of experimental chronic pancreatitis.
    [Nature Communications]

    Full Article

    Synaptotagmin-13 Orchestrates Pancreatic Endocrine Cell Egression and Islet Morphogenesis

    By internalizing a subset of plasma membrane proteins at the front domain, including α6β4 integrins, Syt13 modulated cell-matrix adhesion and allowed efficient endocrine cell egression.
    [Nature Communications]

    Full Article

    Wound Healing in Aged Skin Exhibits Systems-Level Alterations in Cellular Composition and Cell-Cell Communication

    Scientists used single-cell RNA sequencing to define the epithelial, fibroblast, immune cell types, and encompassing heterogeneities in young and aged skin during homeostasis and identified major changes in cell compositions, kinetics, and molecular profiles during wound healing.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Conducting Polymer-ECM Scaffolds for Human Neuronal Cell Differentiation

    Using the freeze-drying technique, porous 3D composite scaffolds consisting of poly (3,4-ethylene-dioxythiophene) doped with polystyrene sulfonate, containing ECM components were engineered for hosting neuronal cells.
    [Advanced Healthcare Materials]

    Abstract

    ADAMTS10 Inhibits Aggressiveness via JAK/STAT/C-MYC Pathway and Reprograms Macrophage to Create an Anti-malignant Microenvironment in Gastric Cancer

    Researchers unveiled the role of disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10) in gastric cancer.
    [Gastric Cancer]

    Abstract

    Peptide Nanogels as a Scaffold for Fabricating Dermal Grafts and 3D Vascularized Skin Models

    Investigators tested the efficacy of ultrashort tetrameric peptides for the fabrication of dermal grafts and 3D vascularized skin tissue models.
    [Journal of Tissue Engineering]

    Full ArticleGraphical Abstract

    Sulfated Glycosaminoglycans Inhibit Transglutaminase 2 by Stabilizing Its Closed Conformation

    The authors investigated the recognition of glycosaminoglycans derivatives by transglutaminase 2 using an enzyme-crosslinking activity assay in combination with in silico molecular modeling and docking techniques.
    [Scientific Reports]

    Full Article

    Effects of Protease Inhibitors on Dentin Erosion: An In Situ Study

    Researchers evaluated the effects of the inhibitors of matrix metalloproteinases and cysteine cathepsins on dentin erosion.
    [Clinical Oral Investigations]

    Abstract

    Proteome and Phosphoproteome Signatures of Recurrence for HPV+ Head and Neck Squamous Cell Carcinoma

    To gain insights into the mechanisms of recurrence and to inform patient stratification and personalized treatment, investigators compared the proteome and phosphoproteome of recurrent and non-recurrent tumors by quantitative mass spectrometry.
    [Communications Medicine]

    Full Article

    Listen to the Stem Cell Podcast episodes covering ISSCR 2022 sessions.
    REVIEWS

    The Biofilm Life Cycle: Expanding the Conceptual Model of Biofilm Formation

    The authors describe the origin of the current five-step biofilm development model and why it fails to capture many aspects of bacterial biofilm physiology.
    [Nature Reviews Microbiology]

    Full Article

    Origin of Critical Nature and Stability Enhancement in Collagen Matrix Based Biomaterials: Comprehensive Modification Technologies

    Various existing modification methods are classified from a new perspective, scilicet whether to introduce exogenous substances, to reveal the basic scientific theories of collagen modification.
    [International Journal of Biological Macromolecules]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Regenative Labs and AAPC Announce Collaboration to Further Healthcare Compliance

    Regenative Labs and AAPC announced a strategic healthcare compliance collaboration. They will support the pioneering of the first Wharton’s jelly allografts to be approved for application directly to a defect using a syringe.
    [Regenative Labs (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

    Advances in Therapeutic Applications of Stem Cells

    December 8 – 10, 2022
    Los Angeles, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Master Thesis – Biohybrid Synapse on Flexible Substrates

    Jülich Research Centre – Jülich, Germany

    Faculty Position – Cancer Biology

    Mayo Clinic – Scottsdale, Arizona, United States

    Postdoctoral Researcher – Biofabrication of 3D Bone Metastasis Model

    Warsaw University of Technology – Warsaw, Poland

    Research Assistant Professor – Cardiovascular and Regenerative Medicine

    Ohio State University Wexner Medical Center – Columbus, Ohio, United States

    Postdoctoral Researcher – Microfluidics, Organoids, and Precision Medicine

    Lehigh University – Bethlehem, Pennsylvania, Untied States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Extracellular Matrix News Twitter