Hematopoiesis News Volume 13.32 | Aug 16 2022

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    Danielle Corrigan
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    2022-08-16 | HN 13.32


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.32 – 16 August, 2022
    TOP STORY

    Diverse Mutational Landscapes in Human Lymphocytes

    After developing protocols for expansion of single-cell lymphocyte cultures, the authors sequenced whole genomes from 717 normal naive and memory B and T cells and HSCs.
    [Nature]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Unprecedented Small Molecule-Based Uniform Two-Dimensional Platelets with Tailorable Shapes and Sizes

    Investigators reported the construction of unprecedented uniform 2D platelets with tailorable shapes and controlled sizes by creating new nuclei from a donor–acceptor molecule and 1-hexanol to initiate 2D living self-assembly.
    [Journal of the American Chemical Society]

    AbstractGraphical Abstract

    Competition between Hematopoietic Stem and Progenitor Cells Controls Hematopoietic Stem Cell Compartment Size

    Scientists suggested that an intricate homeostatic balance between HSCs and proximal hematopoietic progenitors was regulated by cell competition for limited amounts of membrane-bound stem cell factor.
    [Nature Communications]

    Full Article

    Ultra-Deep Sequencing Validates Safety of CRISPR/Cas9 Genome Editing in Human Hematopoietic Stem and Progenitor Cells

    In three separate primary human hematopoietic stem and progenitor cell donors assessed in technical triplicates, researchers electroporated high-fidelity Cas9 protein targeted to three loci and harvested genomic DNA at days four and ten.
    [Nature Communications]

    Full Article

    miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML

    DNA methylation and miRNA expression were evaluated in human AML patient samples and in Dnmt3a/Flt3-mutant AML mice.
    [Clinical Cancer Research]

    Abstract

    Alternatively Spliced CSF3R Isoforms in SRSF2 P95H Mutated Myeloid Neoplasms

    The authors reported that the myelodysplastic syndromes-associated splicing factor SRSF2 affected the expression of Class III and Class IV isoforms and perturbed granulopoiesis.
    [Leukemia]

    Full Article

    Inhibition of Mutant IDH1 Promotes Cycling of Acute Myeloid Leukemia Stem Cells

    Using a multi-allelic mouse model of IDH1-mutant AML, investigators demonstrated that the clinical IDH1 inhibitor AG-120 exerted cell-type-dependent effects on leukemic cells, promoting delayed disease regression.
    [Cell Reports]

    Full ArticleGraphical Abstract

    γ-Secretase Inhibitors Augment Efficacy of BCMA-Targeting Bispecific Antibodies against Multiple Myeloma Cells without Impairing T Cell Activation and Differentiation

    Scientists defined the impacts of γ-secretase inhibitors on T-cell-dependent BCMA-specific multiple myeloma cell lysis and immunomodulatory effects induced by bispecific antibodies.
    [Blood Cancer Journal]

    Full Article

    Phenotypically-Defined Stages of Leukemia Arrest Predict Main Driver Mutations Subgroups, and Outcome in Acute Myeloid Leukemia

    The authors established a novel flow cytometry-based immunophenotypic stratification showing that AML blasts were blocked at specific stages of differentiation where features of normal myelopoiesis were preserved.
    [Blood Cancer Journal]

    Full Article

    Sorting Nexin 24 Is Required for α-Granule Biogenesis and Cargo Delivery in Megakaryocytes

    Reserachers investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets harboring a DNA-binding variant of FLI1.
    [Haematologica]

    Full Article

    Potent Preclinical Activity of FLT3-Directed Chimeric Antigen Receptor T Cell Immunotherapy against FLT3-Mutant Acute Myeloid Leukemia and KMT2A-Rearranged Acute Lymphoblastic Leukemia

    Investigators developed monovalent FLT3-targeted CAR T cells (FLT3CART) and bispecific CD19xFLT3CART and assessed their anti-leukemia activity in preclinical models of FLT3-mutant AML and KMT2Arearranged infant ALL.
    [Haematologica]

    Abstract

    Detection of Early Seeding of Richter Transformation in Chronic Lymphocytic Leukemia

    The authors characterized the whole genome, epigenome and transcriptome, combined with single-cell DNA/RNA-sequencing analyses and functional experiments, of 19 cases of chronic lymphocytic leukemia developing Richter transformation.
    [Nature Medicine]

    Full Article

    An Immunity and Pyroptosis Gene-Pair Signature Predicts Overall Survival in Acute Myeloid Leukemia

    In this retrospective multi-cohort study, scientists investigated whether combining pyroptosis- and immune-related genes improved prognostic classification of AML patients.
    [Leukemia]

    Full ArticleGraphical Abstract

    Explore this validated protocol for high-efficiency CRISPR-Cas9 gene editing of Human Primary T Cells.
    REVIEWS

    Sodium-Glucose Co-Transporter 2 Inhibitors and Hematopoiesis

    The authors presented the potential pathways by which sodium-glucose cotransporter 2 inhibitors may have modulated hematopoiesis and stimulated erythropoiesis.
    [Journal of Cellular Physiology]

    Abstract

    Therapy Resistance Mechanisms in Hematological Malignancies

    Scientists discuss that cellular heterogeneity and plasticity, together with adaptive genetic and epigenetic processes, lead to reduced sensitivity to various treatment regimens such as chemotherapy and pathway inhibitors such as tyrosine kinase inhibitors.
    [International Journal of Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    NexImmune Sizes Up the Competition and Decides to Pause Myeloma T Cell Therapy Plans

    Turns out NexImmune is not resistant to the tough competition in multiple myeloma. The company cited the competitive environment in the blood cancer space as reason for pausing enrollment on one of its two clinical candidates.
    [Fierce Biotech]

    Press Release

    FEATURED EVENT

    5th International Cancer Symposium

    November 2-4, 2022
    Lyon, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scholar – Cancer TCR Gene Therapy

    The University of Chicago – Chicago, Illinois, United States

    Research Project Coordinator – Biology

    Dalla Lana School of Public Health – Toronto, Ontario, Canada

    Postdoctoral Fellow – Stem Cell Biology

    University of Illinois at Chicago – Chicago, Illinois, United States

    Director – Division of Blood Diseases and Resources

    National Institutes of Health – Bethesda, Maryland, United States

    Postdoctoral Researcher – Immuno-Oncology

    Essen University Hospital – Essen, Germany

    > See All Jobs

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