 | | Vol. 14.30 – 1 August, 2023 |
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| Researchers developed CD117/LNP–mRNA, a lipid nanoparticle that encapsulated mRNA and was targeted to the stem cell factor receptor, CD117, on HSCs.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors imagined a future where lab-on-a-chip technologies utilized novel predictive markers of red blood cell quality identified by -omics and machine learning to usher in a new era of safer and precise transfusion medicine.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers generated malignant brain tumor domain containing 1 (Mbtd1) conditional knockout mice and analyzed adult hematopoietic tissues deficient in Mbtd1.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists found that DNAJC10, a member of HSP40 family, was frequently upregulated in various types of AML and in leukemia stem cell-enriched cells.
[Haematologica] |
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| Researchers performed an amino acid drop-out screen and applied pre-clinical models of chronic phase chronic myeloid leukemia (CML) to identify arginine as a nutrient essential for primary human CML cells.
[EMBO Reports] |
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| Investigators examined the clinical significance of genes involved in iron-related cell death and apoptotic pathways in AML, with the intention of providing insights that could have prognostic implications and facilitate the development of targeted therapeutic interventions.
[Frontiers in Oncology] |
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| Scientists examined whether DTX2 was involved in the regulation of RUNX1 using in vitro and ex vivo analyses. DTX2 bound to RUNX1 and other RUNX family members RUNX2 and RUNX3 through their C-terminal region.
[FEBS Journal] |
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| | Researchers characterized the transcriptional and epigenetic landscape with the isocitrate dehydrogenase (IDH) 2i AG-221, using an IDH2 mutated AML cell line model and AML patient cohorts.
[Leukemia] |
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| A total of 59 consecutive subjects diagnosed with myelodysplasia, 48 with AML, and 17 with clonal cytopenia with unknown significance were screened for somatic mutations in AML-related genes by next-generation sequencing.
[European Journal of Haematology] |
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| Transposable elements play a role in hematopoiesis, especially during periods of high cellular plasticity, such as development, regeneration, and aging.
[Disease Models & Mechanisms] |
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| Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
[Science Insider] |
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| September 12 – 14, 2023
Munich, Germany |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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