Hematopoiesis News Volume 8.28 | Jul 18 2017

TOP STORY

Bone Marrow Adipocytes Promote the Regeneration of Stem Cells and Hematopoiesis by Secreting SCF

The authors discovered that bone marrow adipocytes synthesize stem cell factor (SCF). They arose from Adipoq-Cre/ER⁺ progenitors, which represent ~5% of leptin receptor⁺ cells, and proliferated after irradiation. [Nat Cell Biol] Abstract

(Ranked by impact factor of the journal)

Essential Role of FBXL5-Mediated Cellular Iron Homeostasis in Maintenance of Hematopoietic Stem Cells

Researchers showed that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal. Conditional deletion of Fbxl5 in mouse HSCs resulted in cellular iron overload and a reduced cell number. Bone marrow transplantation revealed that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion. [Nat Commun] Full Article

The miR-23a~27a~24-2 MicroRNA Cluster Buffers Transcription and Signaling Pathways during Hematopoiesis

The authors investigated the mechanism by which mirn23a regulates hematopoietic differentiation and observed that mirn23a promotes myeloid development of hematopoietic progenitors through regulation of hematopoietic transcription factors and signaling pathways. [PLoS Genet] Full Article

Dipeptidyl Peptidase‐4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress

Scientists investigated the novel molecular requirements between dipeptidyl peptidase‐4 (DPP4)‐glucagon‐like peptide‐1 (GLP‐1)/GLP‐1 and β3‐adrenergic receptor (Adrβ3)/C‐X‐C motif chemokine 12 (CXCL12) signals in bone marrow (BM) hematopoietic stem cell activation in response to chronic stress. The stress increased the blood and brain DPP4 levels, the plasma epinephrine and norepinephrine levels, and the BM niche cell Adrβ3 expression, and it decreased the plasma GLP‐1 levels and the brain GLP‐1 receptor and BM CXCL12 expressions. [J Am Heart Assoc] Full Article

The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis

Erf is a ubiquitously expressed ets-DNA-binding containing transcriptional repressor. Erf haploinsufficiency caused craniosynostosis in human and mice, while its absence in mice leads to failed chorioallantoic fusion and death at E10.5. Investigators showed that Erf is required in all three waves of embryonic hematopoiesis. [Mol Cell Biol] Abstract

Clock1a Affects Mesoderm Development and Primitive Hematopoiesis by Regulating Nodal-Smad3 Signalings in the Zebrafish Embryo

The authors showed that Clock1a coordinated mesoderm development and primitive hematopoiesis in zebrafish embryos by directly up-regulating Nodal-Smad3 signaling. They found that Clock1a is expressed both maternally and zygotically throughout early zebrafish development. [J Biol Chem] Abstract | Full Article

CLINICAL RESEARCH

MRI-Based Evaluation of Multiorgan Iron Overload Is a Predictor of Adverse Outcomes in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

The medical records of 44 pediatric patients who underwent allogeneic transplantation from 2011 to 2015 were retrospectively reviewed. Investigators compared transplant-related outcomes in the two groups. Iron overload was a negative prognostic risk factor for sinusoidal obstruction syndrome, osteoporosis, pancreatic insufficiency and metabolic syndrome. [Oncotarget] Full Article

A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit ATG Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplants for the Treatment of Myeloid Malignancies

Researchers sought to develop a myeloablative chemotherapeutic regimen to secure consistent engraftment of T-cell depleted hematopoietic stem cell transplants without the need for total body irradiation, thereby reducing toxicity, while maintaining low rates of GvHD and without increasing relapse. [Biol Blood Marrow Transplant] Abstract

Long-Term Systolic Function in Children and Young Adults after Hematopoietic Stem Cell Transplant

Scientists analyzed echocardiograms in 95 children and young adults with malignancies or bone marrow failure syndromes performed before hematopoietic stem cell transplant (HSCT) and 1–6 years after HSCT. In children and young adult survivors of HSCT, ejection fraction was unchanged in the first years after HSCT. [Bone Marrow Transplant] Abstract

Blood on the Tracks: Hematopoietic Stem Cell-Endothelial Cell Interactions in Homing and Engraftment

Recent studies have dissected the unique molecular and physical properties of the endothelial cells in the HSC vascular niche and their role in HSC biology, which may be manipulated to enhance hematopoietic stem cell transplantation therapies. [J Mol Med (Berl)] Abstract

miRNAs in Normal and Malignant Hematopoiesis

The authors highlight the roles of miRNAs in B-cell development and malignancies, and discuss how miRNA expression profiles correlate with disease prognoses and phenotypes. They also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Daiichi Sankyo, Max Planck Innovation and Lead Discovery Center Announce Cancer Research Collaboration

Daiichi Sankyo Co., Limited, Max Planck Innovation GmbH and the Lead Discovery Center GmbH have signed an agreement providing Daiichi Sankyo with the option to receive the exclusive rights to a new lead compound for the treatment of cancer to be discovered and developed at the Lead Discovery Center. [Daiichi Sankyo Co., Limited] Press Release

Second Phase III Study Shows KYPROLIS^® (Carfilzomib) Regimen Significantly Improves Overall Survival in Patients with Relapsed Multiple Myeloma

Amgen announced positive results from the final analysis of the Phase III ASPIRE trial. The study met the key secondary endpoint of overall survival, demonstrating that KYPROLIS^®, lenalidomide and dexamethasone reduced the risk of death by 21 percent over lenalidomide and dexamethasone alone. [Amgen Inc.] Press Release

IMMUNE Pharmaceuticals’ Oncology Subsidiary, CYTOVIA, Announces the Filing of a World-Wide Patent Protecting the Use of Ceplene^® in Acute Myeloid Leukemia (AML) and Other Hematological Cancers with Mutated NPM1

Cytovia, Inc. announced the filing of a patent protecting the use of Ceplene^® in hematologic cancers. The new patent is based on favorable clinical results in patients with AML who had persistent cancer cells in their bone marrow. [Cytovia, Inc. (Business Wire, Inc.)] Press Release

Relatively Few NIH Grantees Get Lion’s Share of Agency’s Funding

The rich have been getting richer in the biomedical research enterprise, and the system favors those who are already doing pretty well, according to a new analysis of National Institutes of Health (NIH) grant recipients. [ScienceInsider] Editorial

Two Female Scientists Sue Salk Institute, Alleging Discrimination at ‘Old Boys Club’

Two senior female scientists are suing their employer, the prestigious Salk Institute for Biological Studies, alleging pervasive, long-standing gender discrimination. In the pair of lawsuits, filed in California Superior Court in San Diego, plaintiffs Vicki Lundblad and Katherine Jones seek unspecified compensation for an array of harms. [ScienceInsider] Editorial

To Woo Public, Europe Opens Up on Animal Experiments, but U.S. Less Transparent

A London-based group that supports the use of animals in biomedical science began inviting the public to take an unusual digital tour of laboratories at four U.K. research institutions. At LabAnimalTour.org, users can watch a monkey with a bolt in its skull forage in its cage at a University of Oxford neuroscience lab and a technician check on some of the 8000 mice housed in one room at the Medical Research Council’s Harwell Institute. [ScienceInsider] Editorial

Why a Flat 2018 Budget Could Tie NSF’s Hands

What would a flat budget mean for the National Science Foundation (NSF)? For many agencies, it means maintaining the status quo. And NSF may have trouble doing anything other than that thanks to some pointed instructions from a key legislator. [ScienceInsider] Editorial

NEW European Society for Medical Oncology (ESMO) 2017 Congress
September 8-12, 2017
Madrid, Spain

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Epigenetics and Immune Signaling in Cancer (Thomas Jefferson University)

NEW Postdoctoral Research Fellow – Molecular and Cellular Therapeutics (Royal College of Surgeons in Ireland)

Postdoctoral Fellow – Regenerative Medicine (Loma Linda University)

Postdoctoral Fellow – Epigenetics of Hematopoiesis (International Clinical Research Center)

Senior/Principal Scientist – Stem Cell Research (Plasticell Ltd)

Postdoctoral Associate – Normal and Malignant Hematopoiesis (University of Miami)

PhD Studentship – Genome Editing of Hematopoietic Stem Cells (CHU Saint Justine Research Center)

Associate Director, Clinical Development – Hematology/Oncology (Jazz Pharmaceuticals)

Postdoctoral Fellow – Stem Cell Biology and Epigenetics (University of South Carolina)

Postdoctoral Fellow – Single Cell Sequencing (University of British Columbia Mechanical Engineering)

Postdoctoral Fellow – Hematopoietic Chimeras (Children’s Hospital of Chicago and Northwestern University)

Postdoctoral Position – Experimental Leukemia Research (University Children’s Hospital Basel)

Lab Director – Pharmacokinetics (Seattle Cancer Care Alliance)

Postdoctoral Fellow – Age Associated Changes of the Hematopoietic Stem Cell Compartment (National Institutes of Health/National Institute on Aging)

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