Hematopoiesis News Volume 9.27 | Jul 10 2018

TOP STORY

Somatic Mutations Precede Acute Myeloid Leukemia Years before Diagnosis

The authors discovered that mutations in IDH1, IDH2, TP53, DNMT3A, TET2 and spliceosome genes significantly increased the odds of developing acute myeloid leukemia (AML). All subjects with TP53 mutations and IDH1 and IDH2 mutations eventually developed AML in the study. [Nat Med] Abstract | Press Release

(Ranked by impact factor of the journal)

Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs

Investigators used γ-retroviral integration sites from a gene therapy trial for ten patients with Wiskott-Aldrich syndrome to mark active enhancers and promoters in functionally defined long-term repopulating HSCs. [Cell Stem Cell] Abstract | Graphical Abstract

Self-Repopulating Recipient Bone Marrow Resident Macrophages Promote Long-Term Hematopoietic Stem Cell Engraftment

Investigators used a myeloid reporter gene to dissect the persistence of bone marrow and splenic macrophage subsets following lethal irradiation and autologous hematopoietic stem cell transplantation in a mouse model. [Blood] Abstract

Spleen Mediates a Distinct Hematopoietic Progenitor Response Supporting Tumor-Promoting Myelopoiesis

Researchers showed that heightened splenic myelopoiesis in tumor-bearing hosts was not only characterized by the accumulation of myeloid precursors, but also associated with profound functional alterations of splenic early hematopoietic stem/progenitor cells. [J Clin Invest] Full Article

Quantitative Spatial Analysis of Hematopoiesis-Regulating Stromal Cells in the Bone Marrow Microenvironment by 3D Microscopy

Using three-dimensional quantitative microscopy we show that sinusoidal endothelial and mesenchymal reticular subsets are remarkably more abundant than estimated by conventional flow cytometry. Moreover, both cell types assemble in topologically complex networks, associate to extracellular matrix and pervade marrow tissues. [Nat Commun] Full Article

Ca²⁺-Mitochondria Axis Drives Cell Division in Hematopoietic Stem Cells

To elucidate the mechanism underlying the transition of cell cycle state in HSCs, scientists analyzed the change of mitochondria in HSCs after bone marrow suppression induced by 5-fluoruracil. [J Exp Med] Abstract | Graphical Abstract

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

Researchers found that UM171 significantly enhanced both the lentivirus-mediated transduction and yield of CD34⁺ and CD34⁺CD45RA^– hematopoietic cells from human cord blood to give a six-fold overall higher recovery of transduced hematopoietic stem cells, including cells with long-term lympho-myeloid repopulating activity in immunodeficient mice. [Mol Ther Methods Clin Dev] Abstract

Aberrant Wnt Signaling Pathway in the Hematopoietic Stem/Progenitor Compartment in Experimental Leukemic Animal

Scientists investigated the pathobiology of leukemia by studying the expression profile of Wnt proteins, receptors, key signaling intermediates and endogenous Wnt antagonist involved in canonical and non-canonical pathways in the bone marrow hematopoietic stem/progenitor cell compartment of experimental leukemic mice. [J Cell Commun Signal] Abstract

CLINICAL RESEARCH

Outcome of Domino Hematopoietic Stem Cell Transplantation in Humans – an International Case Series

Researchers demonstrated that at a median follow up of ten years, domino-HSCT results in overall survival of 80%, event-free survival of 49%, and low risk of GvHD. [J Allergy Clin Immunol] Abstract

Depletion of αβ⁺ T Cells for a Haploidentical Hematopoietic Stem Cell Transplantation in Children

The authors evaluated the efficacy of an ex vivo technique for depletion of αβ⁺ T cells using a biotinylated anti-TCRαβ monoclonal antibody, which was performed by one clinical nurse specialist. Between 2012 and 2017, 119 depletion procedures from 216 apheresis using the anti-TCRαβ monoclonal antibody were performed on 105 pediatric patients. [J Clin Apher] Abstract

Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News.

Protagonist or Antagonist? The Complex Roles of Retinoids in the Regulation of Hematopoietic Stem Cells and their Specification from Pluripotent Stem Cells

The authors summarize the known roles of vitamin A and retinoic acid receptors in the regulation of hematopoiesis from HSCs, embryonic stem and induced pluripotent stem cells. [Exp Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

European Commission Approves Expanded Indication for Sprycel (Dasatinib) to Include Treatment of Children with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase

Bristol-Myers Squibb Company announced that the European Commission has expanded the indication for Sprycel to include the treatment of children and adolescents aged one year to 18 years with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase, and to include a powder for oral suspension formulation. [Bristol-Myers Squibb Company] Press Release

Aptose Biosciences and CrystalGenomics Announce Issuance of Japanese Patent for CG-806

Aptose Biosciences Inc. announced that the Japan Patent Office has issued Japanese Patent No. 6325573 for CG-806. The granted patent claims various compounds, including the CG-806 compound, pharmaceutical compositions comprising the CG-806 compound, and uses for the treatment of various diseases, such as cancer. [Aptose Biosciences, Inc.] Press Release

Kalytera Announces Pre-IND Meeting Date with FDA

Kalytera Therapeutics, Inc. announced that it will meet with the Center for Drug Evaluation and Research of the FDA on Tuesday, July 31, 2018. The meeting is to discuss numerous aspects of Kalytera’s planned registration study evaluating cannabidiol for the treatment of acute graft versus host disease. [Kalytera Therapeutics, Inc.] Press Release

Report Advocates Broader Return of Research Results

A 335-page report from the National Academies of Sciences, Engineering, and Medicine urges researchers and regulators to return more biological data to the people whose samples yielded it in the first place. [ScienceInsider] Editorial

New Scheme for Overseas Researchers to Come to the UK

The new ‘UKRI Science, Research and Academia’ scheme, which allows non-EEA researchers, scientists and academics to come to the UK for up to two years, opened on Friday 6 July. The new scheme, which is being added to the Tier 5 visa route, has been introduced to reflect and encourage the ongoing growth of the research sector in the UK. [UK Visas and Immigration] Editorial

Germany’s Prestigious Max Planck Society Investigates New Allegations of Abuse

The Max Planck Society, one of Germany’s wealthiest and most prestigious research organizations, is investigating fresh allegations of bullying and sexual harassment following an anonymous survey at one of its institutes. [Nature News] Editorial

NEW Annual Sickle Cell Disease and Thalassaemia Conference (ASCAT) 2018
October 22-24, 2018
London, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Endowed Chair – Cancer Research (University of Iowa Health Care)

Research Technologist – Hematopoietic (STEMCELL Technologies Inc.)

Investigator Scientist – DNA Repair Pathways (Medical Research Council)

Postdoctoral Research Fellows – Tissue Morphogenesis (Max-Planck-Institute for Molecular Biomedicine)

Career Development Program – Glycoscience (BloodCenter of Wisconsin)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Postdoctoral Researcher – Regulation of Normal and Malignant Hematopoiesis (Karolinska Institutet)

Research Fellow – Epigenetics and Hematology (University of Edinburgh)

Postdoctoral Fellow – Leukemogenesis (Erasmus Medical Center Cancer Institute)

Postdoctoral Position – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Postdoctoral Research Associate – Mechanisms of Leukemia (University of Virginia)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Hematopoiesis News? Click here to submit!

Comments or suggestions? Submit your feedback here.