 | | Vol. 4.37 – 9 October, 2020 |
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| Oncogenic function of RNase7 was analyzed by cell proliferation, migration, invasion assays and xenograft mouse model. The anti-ROS1 inhibitor treatment efficacy was evaluated in hepatocellular carcinoma patient-derived xenograft and orthotopic models.
[Journal of Hepatology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Combining olaparib with NU7441, a DNA-PKcs inhibitor that blocks nonhomologous end-joining in hepatocellular carcinoma (HCC), synergistically suppressed HCC growth in both mice and HCC patient-derived-xenograft models.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Dysregulated lncRNAs in hepatocellular carcinoma (HCC) were identified through circlncRNAnet and GEPIA bioinformatics tools. Biological function of LL22NC03-N14H11.1 in HCC was detected by CCK-8 assay, flow cytometry analysis, transwell invasion, and wound healing assays.
[Cell Death & Disease] |
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| Immunohistochemical analysis performed on two independent hepatocellular carcinoma (HCC) cohorts confirmed the upregulation of EFTUD2 in HCC tissues and further suggested that a high level of EFTUD2 expression predicted shorter overall and recurrence-free survival in HCC patients.
[Cell Death & Disease] |
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| Researchers examined the metabolic effects of fructose on hepatocellular carcinoma growth in vitro and in vivo. Fructose sugar was found to reduce cell growth in vitro, and caused alterations in the expression of enzymes involved in the serine-glycine synthesis and pentose phosphate pathways.
[Scientific Reports] |
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| Because N-acetyltransferase (NAT) is expressed in hepatocytes, whereas CD38 is expressed in Kupffer cells and hepatic stellate cells, investigators explored cell type-specific roles of CD38 in the formation of a primary INH metabolite mediated isoniazid (INH)-β-nicotinamide adenine dinucleotide (NAD) as well as INH-NAD.
[Drug Metabolism and Disposition] |
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| The pcDNA3.1-NFAT2 plasmid was transfected into HepG2 cells to construct NFAT2 overexpressed HepG2 cells. Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed.
[BMC Cancer] |
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| Scientists explored whether p53 played a crucial role in the senescence of activated hepatic stellate cells and degradation of collagen mediated by interleukin-10.
[Experimental Biology and Medicine] |
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| The authors collected the evidence of HGF/c‐Met as a tumor progression and prognostic marker, discussed the anti‐c‐Met therapy in vitro, summarized the outcome of c‐Met inhibitors in clinical trials, and identified potential impetus for future anti‐c‐Met treatments.
[Medicinal Research Reviews] |
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| Investigators demonstrate that combination of different immunotherapies or immunotherapy with other modalities results in better overall survival and progression free survival compared to single immunotherapy agent.
[Cancers] |
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| A trio of scientists who identified and characterized the virus responsible for many cases of hepatitis and liver disease- hepatitis C- are the recipients of the 2020 Nobel Prize in Physiology or Medicine.
[Nature News] |
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| New blood tests and drugs for this deadly disease have already saved millions of lives. But for millions more around the world, the celebration is bittersweet and the revolution in diagnosis and treatment remains a distant dream.
[STAT News] |
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| Provectus announced the completion of enrollment of 12 patients into the company’s Phase I study of small molecule autolytic cancer immunotherapy PV-10, an injectable formulation of Provectus’ proprietary rose bengal disodium, for the treatment of symptomatic neuroendocrine tumors metastatic to the liver refractory to somatostatin analogs and peptide receptor radionuclide therapy.
[Provectus Biopharmaceuticals] |
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| January 25 – January 28, 2021
Virtual |
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| | Company – Vienna, Austria |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | University of Toronto – Toronto, Ontario, Canada |
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| | University of Miami – Miami, Florida, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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