 | | Vol. 6.23 – 24 June, 2022 |
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| Cells expressing human sodium-taurocholate cotransporting polypeptide were inoculated with hepatitis B virus (HBV) or hepatitis delta virus. HBV pre-genomic RNA, covalently closed circular DNA and different relaxed circular DNA intermediates were produced in vitro.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To identify liver-regulated pathways linking intra-hepatic and plasma triglyceride metabolism, researchers performed transcriptomic analysis of liver biopsies from two independent cohorts of obese patients.
[Hepatology] |
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| Scientists reported that macroH2A1.2 and macroH2A2 modulated the transcriptional ground state of cancer cells and how they responded to inflammatory cytokines.
[Cell Reports] |
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| Silencing ANKFN1 expression suppressed HCC cell proliferation, migration, invasion, and metastasis in vitro and subcutaneous tumorigenesis in vivo.
[Oncogene] |
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| The authors demonstrated that FoxO3 deletion accelerated liver regeneration primarily by limiting polyploidization and promoting the proliferation of hepatocytes during liver regeneration.
[NPJ Regenerative Medicine] |
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| Scientists used a proteomics approach to circumvent the mechanism for lipotoxicity using hepatocellular carcinoma cells as a model.
[Cell Death & Disease] |
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| Researchers reported that hepatic stellate cells (HSCs) underwent senescence within two days after 2/3 partial hepatectomy in young mice, and elimination of these senescent cells by the senolytic drug ABT263 or using a genetic mouse model impaired liver regeneration.
[JCI Insight] |
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| The manifestations of liver injury triggered by P. multiflorum and the associated metabolic enzymes/transporters in the metabolic pathways of bilirubin and bile acid were investigated to elucidate the mechanism and target of the hepatotoxicity of P. multiflorum and related components.
[Journal of Ethnopharmacology] |
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| The authors genotyped 42 non-alcoholic fatty liver disease (NAFLD) patients for three IFNL4 single-nucleotide variants in order to investigate the genetic relationship between IFNL4 and fibrosis in NAFLD patients.
[Genes & Immunity] |
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| Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease. Severity classification and diagnostic approaches regarding mild forms of HE are still a matter of debate.
[Nature Reviews Disease Primers] |
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| Echosens and Novo Nordisk A/S announced a partnership to advance early diagnosis of non-alcoholic steatohepatitis (NASH) and increase awareness of the disease among patients, healthcare providers, and other stakeholders.
[Echosens] |
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| November 7 – 8, 2022
London, England, United Kingdom |
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| | Pennsylvania State University – State College, Pennsylvania, United States |
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| | The Ohio State University Comprehensive Cancer Center – Columbus, Ohio, United States |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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