 | | Vol. 8.02 – 19 January, 2024 |
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| Scientists developed a cis-targeted CD8-interleukin-2 fusion protein, aiming to selectively stimulate dysfunctional CD8+ T cells in chronic hepatitis B virus.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators uncovered in primary hepatocytes from a preclinical model fed with a Western diet an increased basal MET phosphorylation and a strong downregulation of the PI3K-AKT pathway.
[Molecular Systems Biology] |
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| Researchers investigated the roles and mechanisms of Periostin in phenotypic transition of hepatic stellate cells and relevant abnormal cellular crosstalk during liver fibrosis.
[Cell Death & Disease] |
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| Scientists investigated the functional role of transketolase (TKT) in the repair of DNA double-strand breaks (DSBs) in HCC. They unveiled that TKT was involved in DSB repair, and its depletion significantly reduced both non-homologous end joining and homologous recombination-mediated DSB repair.
[Oncogene] |
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| Investigators showed that G protein-coupled receptors (GPCRs) could regulate interferon regulatory factor 3 (IRF3) phosphorylation through GPCR-Gα protein interaction.
[Cell Communication And Signaling] |
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| Researchers investigated the impacts of ginkgetin on liver fibrosis and the underlying mechanisms. The impacts of ginkgetin on liver fibrosis were assessed in mouse models induced by thioacetamide or bile duct ligation.
[Phytotherapy Research] |
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| To gain more accurate understanding, the effects of T-2 toxin were investigated in the present study in chicken-derived 3D primary hepatic cell cultures. 3D spheroids were treated with three concentrations of T-2 toxin for 24 hours.
[Scientific Reports] |
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| Investigators developed a highly efficient method for generating functional liver organoids from human-induced pluripotent stem cell-derived carboxypeptidase M liver progenitor cells, using a microwell structure, and enhanced maturation through direct oxygenation in oxygen-permeable culture plates.
[Biotechnology And Bioengineering] |
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| Researchers investigated the antiproliferative and antitelomerase effects of silymarin on four human colorectal cancer and HepG2 HCC cell lines. The cell viability and telomerase activity were assessed using MTT and the TRAP assay, respectively.
[Planta Medica] |
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| The authors explore the potential of adeno-associated virus (AAV) vectors as versatile tools for targeted gene therapy (GT) in HCC. They encapsulate the multifaceted exploration of AAV vectors in HCC GT, underlining their transformative potential within the landscape of oncology and human health.
[Virology Journal] |
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| Atea Pharmaceuticals, Inc. announced the achievement of two significant clinical milestones from its Hepatitis C Virus (HCV) and COVID-19 programs. The company reported positive initial data from the first 52 patients in the lead-in cohort of its Phase 2 combination 8-week study of bemnifosbuvir and ruzasvir.
[Atea Pharmaceuticals, Inc.] |
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| February 14 – 16, 2024
Hinxton, England, United Kingdom |
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| | Instituto de Investiga̤̣o e Inova̤̣o em Sa̼de da Universidade do Porto РPorto, Portugal |
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| | Karolinska Institutet – Solna, Sweden |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | National University of Singapore – Singapore, Singapore |
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