Hepatic Cell News Volume 8.21 | Jul 19 2024

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    2024-07-19 | HCN 8.22


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.17 – 19 July, 2024
    TOP STORY

    ESRP1-Mediated Biogenesis of circPTPN12 Inhibits Hepatocellular Carcinoma Progression by PDLIM2/ NF-κB Pathway

    A newly discovered hsa-circ-0003764 was identified from the circbase database. QRT-PCR analysis was utilized to assess the expression levels of hsa-circ-0003764 in both HCC tissues and cells.
    [Molecular Cancer]

    Full Article
    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    The Obesity-Related Mutation Gene on Nonalcoholic Fatty Liver Disease

    The authors investigated the impact of high body weight and BMI on HCC survival using The Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset.
    [Human Genetics]

    Abstract

    Proteomic and Phosphoproteomic Profiling of Urinary Small Extracellular Vesicles in Hepatocellular Carcinoma†

    Scientists defined the proteomic and phosphoproteomic landscape of urinary small extracellular vesicles (sEVs) in patients with HCC. Mass spectrometry-based methods were used to detect the global proteome and phosphoproteome profiles of sEVs isolated by differential ultracentrifugation.
    [Analyst]

    AbstractGraphical Abstract

    Interleukin-1 Receptor 1 Deficiency Worsens Hepatocellular Carcinoma, While Gemcitabine Treatment Alleviates the Hepatocellular Carcinoma-Induced Increase in Intra-Hepatic Immune Cells

    Hydrodynamics-based transfection, employing the sleeping beauty transposase system, delivered surrogate tumor antigens, NRAS, ShP53, and SB100 to C57BL/6 mice.
    [Journal of Gastroenterology and Hepatology]

    Full Article

    Changes of Circulating Tumor Cells Expressing CD90 and EpCAM in Early-Phase of Atezolizumab and Bevacizumab for Hepatocellular Carcinoma

    Researchers investigated the cellular characteristics of circulating tumor cells focusing on monitoring during atezolizumab and bevacizumab therapy in patients with HCC. Peripheral blood samples were collected from 10 healthy controls and 40 patients with HCC.
    [Heliyon]

    Full Article

    Single-Cell Analysis Revealed That MTIF2 Could Promote Hepatocellular Carcinoma Progression through Modulating the ROS Pathway

    Gene expression analysis on TIMER 2.0, UALCAN, and GEPIA databases was performed to measure the expression of MTIF2 in HCC tissues.
    [Heliyon]

    Full ArticleGraphical Abstract
    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Role of Hepatocyte Nuclear Factor 4 Alpha in Liver Cancer

    Investigators summarize the role of HNF4α in liver cancer pathogenesis and highlights its potential as a potential therapeutic target for HCC.
    [Seminars in Liver Disease]

    AbstractGraphical Abstract

    Metabolic Dysfunction−Associated Liver Disease and Diabetes: Matrix Remodeling, Fibrosis, and Therapeutic Implications

    While there has been great progress in drug development and clinical trials for MASLD/MASH, the complexity of these pathways highlights the need to improve diagnosis/early detection and develop more successful antifibrotic therapies that not only prevent but reverse fibrosis.
    [Annals of The New York Academy of Sciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    UNSW Joins NSW Government Initiative to Reduce Animal Testing

    UNSW Sydney will form part of a new network established by the NSW government to help reduce and replace animals in medical research.
    [UNSW Sydney]

    Full Article

    HepaRegeniX Raises €15 Million Series C Round to Advance Clinical Development of HRX-215 for Liver Regeneration

    HepaRegeniX GmbH announced the closing of a Series C round led by Vesalius Biocapital IV with participation of existing investors Novo Holdings, Boehringer Ingelheim Venture Fund, and High-Tech Gründerfonds.
    [HepaRegeniX]

    Press Release
    FEATURED EVENT

    Biomolecular Condensates: Mechanisms and Therapeutic Opportunities

    September 6-9, 2024
    Breckenridge, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant Professor – Pharmacology and Pharmacy

    University of Hong Kong – Hong Kong, Hong Kong

    Director – Pediatric Gastroenterology

    University of Michigan – Ann Arbor, Michigan, United States

    Associate Professor – Liver Genomics and Biomarker Development

    University of Copenhagen – Copenhagen, Denmark

    Director – Office of Cancer Centers

    National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Positions – Biochemistry

    Goethe University Frankfurt am Main – Frankfurt, Germany

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