Hepatic Cell News Volume 8.31 | Dec 6 2024

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    Noshin Noorjahan
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    2024-12-06 | HCN 8.31


    Hepatic Cell News by STEMCELL Technologies
    Vol. 8.31 – 6 December, 2024
    TOP STORY

    Fetal Hepatocytes Protect the HSPC Genome via Fetuin-A

    Scientists showed that fetal liver hepatocytes provided protection to hematopoietic stem and progenitor cell (HSPC) genomes.
    [Nature]

    Full Article
    PUBLICATIONSListed by the impact factor of the journal

    Tumor-Associated Neutrophils Attenuate the Immunosensitivity of Hepatocellular Carcinoma

    The authors showed that tumor-associated neutrophils affected metabolic dysfunction-associated steatohepatitis HCC more than viral-associated HCC.
    [Journal of Experimental Medicine]

    Abstract

    Effects of Dapagliflozin on Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

    This randomized, open-label, two-arm, parallel-group trial enrolled patients with nonalcoholic fatty liver disease and a controlled attenuation parameter.
    [Hepatology International]

    Abstract

    Glucose-Induced LINC01419 Reprograms the Glycolytic Pathway by Recruiting YBX1 to Enhance PDK1 mRNA Stability in Hepatocellular Carcinoma

    Researchers revealed that glucose-induced LINC01419 promoted the growth and metastasis of HCC cells by driving metabolic reprogramming.
    [Clinical and Translational Medicine]

    Full Article

    Modeling Metabolic-Associated Steatohepatitis with Human Pluripotent Stem Cell-Derived Liver Organoids

    Human liver organoids derived from human pluripotent stem cells were treated with oleic acid and TGFβ to mimic the metabolic-associated steatohepatitis progression.
    [Hepatology Communications]

    Full ArticleGraphical Abstract

    Cell-Permeated Peptide P-T3H2 Inhibits Malignancy on Hepatocellular Carcinoma through Stabilizing HNF4α Protein

    The expression of tribbles homolog 3 and hepatocyte nuclear factor 4α (HNF4α) was evaluated using western blot and immunohistochemistry.
    [Discover Oncology]

    Full Article
    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    REVIEWS

    Targeting PNPLA3 to Treat MASH and MASH Related Fibrosis and Cirrhosis

    Investigators describe the PNPLA3M 148M genetics, function, and preclinical experimental evidence with therapeutic approaches targeting PNPLA3.
    [Liver International]

    Full Article
    INDUSTRY AND POLICY NEWS

    Four KI Researchers Awarded 2024 ERC Consolidator Grant

    Karolinska Institutet (KI) researchers Emma R. Andersson, Volker Lauschke, Gustaf Edgren, and Alireza Salami have been awarded the European Research Council’s (ERC) prestigious consolidation grant and a total of approximately EUR 8 million for their research.
    [Karolinska Institutet]

    Press Release
    FEATURED EVENT

    Translating Targeted Therapies in Combination with Radiotherapy

    January 26-29, 2025
    San Diego, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Graduate Student – Cellular & Molecular Medicine

    Ottawa Hospital Research Institute – Edmonton, Alberta, Canada/p>

    Researcher – Gastrointestinal and Liver Disease

    University of Alberta Hospital – Edmonton, Alberta, Canada/p>

    Postdoctoral Associate – Metabolic Diseases and Liver Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Research Associate – Metabolism

    Baylor College of Medicine – Houston, Texas, United States

    Faculty Position – Translational Cancer Research

    Northwell Health – Manhasset, New York, United States

    > See All Jobs

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