 | | Vol. 6.22 – 17 June, 2022 |
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| MiR-690 directly inhibited fibrogenesis in hepatic stellate cells, inflammation in recruited hepatic macrophages, and de novo lipogenesis in hepatocytes.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that a mitochondrial protein FUN14 domain containing 2 (FUNDC2) was transcriptionally upregulated in primary mouse liver tumors, and in approximately 40% of human HCC.
[Nature Communications] |
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| The authors introduced a platform for routine grafting of liver and other tissues on an in vitro grown microvascular bed.
[Angiogenesis] |
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| Scientists found that activation of hepatocyte p53 created a microenvironment prone to tumor formation from hepatic progenitor cells and that optimization of p53 activity in hepatocytes was important to prevent chronic liver disease patients from hepatocarcinogenesis.
[Cancer Research] |
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| Intact PPARα activity in hepatocytes was required for the cross-talk between adipose tissues and the liver during fat mobilization.
[Cell Reports] |
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| Investigators reported that Calpain-2 promoted the proliferation and invasion of HCC, and showed a positive correlation with the levels of invasion-related markers.
[Oncogene] |
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| Researchers reported that exosomal miR-411-5p from M2 macrophages inhibited hepatic stellate cells activation and miR-411-5p directly downregulated the expression of calmodulin regulated spectrin associated protein 1 (CAMSAP1) to inactivate stellate cells.
[iScience] |
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| The authors reported that silencing PRDX1 increased the accumulation of ferrous ions and lipid peroxidation accumulation in HEPG2 cells and promoted ferroptosis in hepatocellular carcinoma.
[Scientific Reports] |
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| Scientists revealed that PLIN2 was frequently upregulated in HCC cells and tissues, and increased PLIN2 expression was associated with poor prognosis outcomes in HCC.
[Experimental Cell Research] |
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| HepG2 and SMMC7721 cells were treated with 1.7%, 3.4%, and 5.1 % sevoflurane for six hours. Cell migration was analyzed using invasion, migration, and scratch assays.
[Cell Transplantation] |
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| Investigators review COVID-19 liver manifestations and pathophysiological aspects related to SARS-CoV-2 infection in patients without liver disease as well as the impact of COVID-19 in patients with chronic liver disease, particularly cirrhosis and liver transplantation.
[Gut] |
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| The authors discuss the pros and cons of different immune therapies, observed in patients with chronic hepatitis B (CHB) during the last 30 years, to derive insights into the development of an evidence-based, effective, and patient-friendly regimen of immune therapy for the treatment of CHB.
[Journal of Gastroenterology] |
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| Syndecan-1 represents the major proteoglycan of the liver, expressed by hepatocytes and cholangiocytes, and its elevated expression is a characteristic feature of liver diseases.
[American Journal of Physiology-Cell Physiology] |
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| Surrozen, Inc. announced that the first subject has been dosed in its two-part Phase I clinical trial for SZN-043 which is in development for the potential treatment of severe alcoholic hepatitis.
[Surrozen, Inc.] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | La Jolla Institute for Immunology – La Jolla, California, United States |
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| | Norwegian University of Science and Technology -Trondheim, Norway |
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