 | | Vol. 13.10 – 27 May, 2025 |
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| Researchers investigated how CD39-AS affects the function of Tregs and Th17 cells in healthy subjects and inflammatory bowel disease patients.
[Cellular & Molecular Immunology] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| Investigators identified pyroptosis as a likely mechanism of central nervous system injury underlying progressing independently of relapse activity even outside of clemastine toxicity.
[Journal of Clinical Investigation] |
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| Scientists identified IL-32–expressing CD8+ memory T cells and Tregs as key components of the indoleamine 2,3-dioxygenase 1/programmed death–ligand 1 niche in Sri Lankan patients with cutaneous leishmaniasis and in patients with distinct forms of dermal leishmaniasis in Brazil and India.
[Journal of Clinical Investigation] |
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| Researchers investigated whether lymphocyte-activation gene 3 (LAG-3)/PD-1 inhibition would improve clinical outcomes in a mismatch repair proficient colorectal cancer subset.
[Clinical Cancer Research] |
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| Analysis of RNA-sequencing data revealed a downregulation of the type I interferon response in NRAS-mutant tumors compared with NRAS wild-type tumors, which is associated with poor prognosis in NRAS-mutant melanoma.
[Cancer Research] |
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| Scientists reported an immunocytokine, IGM-7354, which was designed to bind multiple PD-L1 receptors while trans-presenting a single IL-15/IL-15Rα complex on the joining chain to IL-15Rβγ-expressing cytotoxic natural killer and CD8+ T cells.
[Cancer Immunology Research] |
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| Investigators explored whether group 2 innate lymphoid cells (ILC2s) that produce IL-10 could enhance islet function and prevent allograft rejection in humanized mouse models of islet transplantation.
[American Journal of Transplantation] |
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| Scientists described the development of a flow cytometry-based assay to assess leucine-rich repeat protein kinase 2 (LRRK2) activity in individual cells and the generation of an EGFP-Lrrk2 knock-in reporter mouse to analyse cell-specific LRRK2 expression.
[EMBO Reports] |
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| Researchers investigated the molecular mechanism underlying transformation of chronic lymphocytic leukemia to histiocytic sarcoma with indeterminate dendritic cell features.
[American Journal of Clinical Pathology] |
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| The authors focus on the experimental evidence suggesting that expression of X-linked genes due to dysregulation in X chromosome inactivation maintenance could contribute to the female predisposition for autoautoimmunity.
[European Journal of Immunology] |
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| Brain Cancer Canada awarded $68,000 for an innovative research initiative led by Dr. Aru Narendran and Dr. Patrick Sipila, at The University of Calgary and Alberta Children’s Hospital.
[Brain Cancer Canada (Globe Newswire)] |
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| June 24-27, 2024
Heidelberg, Germany and Virtual |
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| | King’s College London – London, England, United Kingdom |
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| | Karolinksa Institutet – Solna, Sweden |
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| | University of Glasgow – Glasgow, Scotland |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Fondazione per l’Istituto oncologico di ricerca IOR – Bellinzona, Switzerland |
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