Human Immunology News Volume 9.41 | Oct 19 2021

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    2021-10-19 | HIN 9.41


    Human Immunology News by STEMCELL Technologies
    Vol. 9.41 – 19 October, 2021
    TOP STORY

    Spatially Confined Sub-Tumor Microenvironments in Pancreatic Cancer

    Investigators deconvoluted the human pancreatic tumor microenvironment through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models.
    [Cell]

    Full ArticleGraphical Abstract


    Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Costimulation Molecules Differentially Regulate the ERK-Zfp831 Axis to Shape T Follicular Helper Cell Differentiation

    Scientists found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.
    [Immunity]

    AbstractGraphical Abstract

    CD73-Mediated Adenosine Production by CD8 T Cell-Derived Extracellular Vesicles Constitutes an Intrinsic Mechanism of Immune Suppression

    The authors showed that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner.
    [Nature Communications]

    Full Article

    Genomic and Transcriptomic Correlates of Immunotherapy Response within the Tumor Microenvironment of Leptomeningeal Metastases

    To examine the efficacy of immune checkpoint inhibitors in patients with Leptomeningeal disease, researchers completed two Phase II clinical trials.
    [Nature Communications]

    Full Article

    Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy

    Researchers demonstrated the first application of label-free Raman spectroscopy for elucidating biomolecular changes induced by anti-CTLA-4 and anti-PD-L1 immune checkpoint inhibitors in the tumor microenvironment of colorectal tumor xenografts.
    [Cancer Research]

    Abstract

    Proinflammatory Cytokines Promote TET2-Mediated DNA Demethylation during CD8 T Cell Effector Differentiation

    To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, scientists explored the role of interleukin-12 in the imprinting of IFNg expression during CD8 T cell priming.
    [Cell Reports]

    Full ArticleGraphical Abstract

    PI3Kδ Coordinates Transcriptional, Chromatin, and Metabolic Changes to Promote Effector CD8+ T Cells at the Expense of Central Memory

    Using patient samples and a mouse model, scientists demonstrated that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibited exaggerated features of effector populations both in vitro and after viral infection that were associated with increased Fas-mediated apoptosis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Prognostic Implications of Tumor-Infiltrating T Cells in Early-Stage Endometrial Cancer

    The proportion of T cells and their subpopulations were associated with clinicopathological features and relapse-free survival outcomes. CD3+ CD4+ infiltrates were more abundant in the patients with higher grade or non-endometrioid histology.
    [Modern Pathology]

    Abstract

    Therapeutically Expanded Human Regulatory T Cells Are Super-Suppressive Due to HIF1A Induced Expression of CD73

    Scientists demonstrated that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha driven acquisition of CD73 expression.
    [Communications Biology]

    Full Article

    Machine Learning Identification of Specific Changes in Myeloid Cell Phenotype during Bloodstream Infections

    An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to control subjects, postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and blood culture-positive patients.
    [Scientific Reports]

    Full Article

    Differential Expression Profile of Gluten-Specific T Cells Identified by Single-Cell RNA-Seq

    In this first single-cell RNA-seq study of tetramer-sorted T cells from untreated celiac disease patients blood, investigators found that gluten-specific T cells showed distinct transcriptomic profiles consistent with activated effector memory T cells that shared features with Th1 and follicular helper T cells.
    [PLOS ONE]

    Full Article

    Differential Levels of mRNAs in Normal B Lymphocytes, Monoclonal B Lymphocytosis and Chronic Lymphocytic Leukemia Cells from the Same Family Identify Susceptibility Genes

    Researchers hypothesized that progressive changes in gene expression resulted in malignant transformation of B lymphocytes to family histroy of monoclonal B lymphocytosis, and subsequent alterations in gene expression occur before overt family history of chronic lymphocytic leukemia develops.
    [Oncology and Therapy]

    Full Article

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    REVIEWS

    Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

    Recent advances in bioinspired delivery platforms for cancer vaccines, existing obstacles faced, as well as insights and future directions for the field are discussed.
    [Advanced Materials]

    Abstract

    INDUSTRY AND POLICY NEWS

    Bristol Myers Squibb Receives Positive CHMP Opinion for Zeposia (Ozanimod) as a Treatment for Adult Patients with Moderately to Severely Active Ulcerative Colitis

    Bristol Myers Squibb announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of Zeposia for the treatment of adults with moderately to severely active ulcerative colitis who have had an inadequate response, lost response, or were intolerant to either conventional therapy or a biologic agent.
    [Bristol Myers Squibb]

    Press Release

    Pfizer’s Abrocitinib Receives Positive CHMP Opinion for the Treatment of Adults with Moderate to Severe Atopic Dermatitis

    Pfizer, Inc. announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has adopted a positive opinion recommending the 100 mg and 200 mg doses of abrocitinib, an oral, once-daily, Janus kinase 1 inhibitor, for marketing authorization to treat moderate to severe atopic dermatitis in adults who are candidates for systemic therapy.
    [Pfizer, Inc.]

    Press Release

    FEATURED EVENT

    FSSCR French Society for Stem Cell Research

    November 9 – 10, 2021
    Montpellier, France

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Hematological Trait Genomics

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Assistant Professor – Cancer Research

    University of Manitoba – Winnipeg, Manitoba, Canada

    Postdoctoral Fellow – Inflammatory Bowel Diseases

    Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Position – Cancer Biology

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Position – Translational Oncology

    Medical University of Vienna – Vienna, Austria

    > See All Jobs

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