 | | Vol. 10.21 – 1 June, 2022 |
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| Researchers analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, over 20% of whom had delayed viral clearance. Delayed clearance was associated with loss of antibodies to nucleocapsid and spike proteins with a compensatory increase in functional T cell responses.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists evaluated virus-neutralizing capacity against SARS-CoV-2 variants by age-stratified analyses in 177 pediatric patients hospitalized with severe acute COVID-19, acute multisystem inflammatory syndrome in children (MIS-C), and in convalescent samples of outpatients with mild COVID-19.
[Nature Communications] |
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| To define host defense and immunosuppressive functions of normal density neutrophils and low density neutrophils from COVID-19 patients, investigators recruited 64 patients with severe COVID-19 and 26 healthy donors.
[Frontiers in Immunology] |
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| The authors conducted infection experiments in bronchial organoids (BO) and an BO-derived air-liquid interface model using eight SARS-CoV-2 variants.
[Communications Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists showed that acute respiratory distress syndrome patients were hypoxemic and monocytopenic within the first 48 hours of ventilation. Monocytopenia was also observed in mouse models of hypoxic acute lung injury, in which hypoxemia drove the suppression of type I interferon signaling in the bone marrow.
[Nature Immunology] |
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| The authors showed that human cytomegalovirus-encoded UL37 exon-1 protein (UL37x1) not only inhibited apoptosis but also suppressed the cGAS-STING immune pathway.
[Nature Microbiology] |
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| Investigators showed that rhesus macaques regularly cleared acute Hepatitis B virus infection, similar to adult humans, but could develop long-term infection if immunosuppressed.
[Nature Communications] |
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| Researchers explored the role of antigen valency in MHC class II-targeted vaccines delivered as DNA.
[Cell Reports] |
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| Investigators used rhesus macaques to study the early effects of simian immunodeficiency virus (SIV) co-infection on pulmonary granulomas.
[Cell Reports] |
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| Using an S. aureus strain engineered to express a trackable CD4+ T cell epitope and a murine model of S. aureus pneumonia, scientists showed strategies that lodged Th1 polarised bacterium specific CD4+ tissue-resident memory T cells in the lung could significantly attenuate the severity of S. aureus pneumonia.
[Mucosal Immunology] |
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| The authors tested two accelerated three-dose schedules of accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens assessing efficacy by controlled human malaria infection against placebo.
[npj Vaccines] |
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| To overcome the limited cross protection and low efficacy by hemagglutinin (HA) stem vaccination, scientists genetically engineered a chimeric conjugate of thermostable H1 HA stem and highly conserved M2e repeat, which was expressed at high yields in Escherichia coli.
[Molecular Therapy-Methods & Clinical Development] |
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Using a spaceflight analogue low fluid shear culture system, researchers investigated the effect of low shear modeled microgravity culture on the colonization of Salmonella Typhimurium in a 3D biomimetic model of human colonic epithelium containing macrophages.
[Frontiers in Cellular and infection Microbiology] |
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| Scientists adress the involvement of persistent enterovirus infection in triggering islet autoimmunity and type 1 diabetes mellitus (T1DM), as well as current strategies to control enterovirus infections for preventing or reducing the risk of T1DM onset.
[Nature Reviews Endocrinology] |
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| The authors review the common features and peculiarities of precursor cells in acute infections, different types of persistent infection, and cancer.
[Nature Immunology] |
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| Scientists summarize the origin, intermediate hosts, and the current understanding of interspecies transmission of MERS-CoV, SARS-CoV, SARS-CoV-2, Nipah, Hendra, Ebola, Marburg virus and rotaviruses.
[Cell Reports] |
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| Clover Biopharmaceuticals, Ltd. announced the first participants have been dosed in a Phase I clinical trial to assess the safety and immunogenicity of several formulations of SCB-2020S.
[Clover Biopharmaceuticals, Ltd.] |
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| A highly infectious and deadly strain of avian influenza virus has infected tens of millions of poultry birds across Europe, Asia, Africa and North America. But scientists are particularly concerned about the unprecedented spread in wild birds.
[Nature News] |
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| It’s been three weeks since public-health authorities confirmed a case of monkeypox in the United Kingdom. The situation has scientists on alert because the monkeypox virus has emerged in separate populations across multiple countries, and there is no obvious link between many of the clusters.
[Nature News] |
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| For nearly two years, as the Covid pandemic disrupted life around the globe, other infectious diseases were in retreat. Now, as the world rapidly dismantles the measures put in place to slow spread of Covid, the viral and bacterial nuisances that were on hiatus are returning — and behaving in unexpected ways.
[STAT News] |
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| June 21 – 24, 2022
San Francisco, California, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The Walter and Eliza Hall Institute – Parkville, Australia |
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| | Nationwide Children’s Hospital – Columbus, Ohio, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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