 | | Vol. 10.25 – 29 June, 2022 |
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| Mycobacteria played a critical role in tumor necrosis factor (TNF)-induced necrosis at two distinct steps. They were required together with TNF to increase glutaminolysis and then again with the resultant mitochondrial reactive oxygen species (ROS) to induce necrosis.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers compared virological attributes of the SARS-CoV-2 Omicron variant of concern with those of the Delta variant in a Syrian hamster model of COVID-19.
[Science] |
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| Investigators combined influenza and SARS-CoV-2 infection with fluorescent-reporter mice to identify memory B cells regardless of antigen specificity.
[Immunity] |
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| The authors investigated virus spread and associated pathology in the upper and lower respiratory tracts of Syrian golden hamsters at four days post intranasal SARS-CoV-2 Omicron infection, in comparison to infection with variants of concern Gamma and Delta as well as ancestral strain 614 G.
[Nature Communications] |
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| Combining homology modeling, protein-protein docking, and molecular dynamics simulations, scientists developed a full spike structure in a native membrane.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| To evaluate whether the aminothiol cysteamine exerted antiviral effects against SARS-CoV-2 variants, investigators performed different infected cell-based assays using Wild type, Delta, or Omicron variants of concern.
[Cell Death Discovery] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors showed that Aire+MHCII+ type 3 innate lymphoid cells could sense, internalize, and present C. albicans and had a critical role in the induction of Candida-specific T helper 17 (TH17) cell clones.
[Nature Immunology] |
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| Investigators used fluorescently labeled probes and flow cytometry to evaluate the antigen specificity and phenotype of respiratory syncytial virus F–specific B cells longitudinally after DS-Cav1 immunization.
[Science Translational Medicine] |
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| Scientists reported the identification and characterization of the M. marinum actin-based motility factor designated mycobacterial intracellular rockets A, which is a member of the glycine-rich PE_PGRS protein family.
[Nature Communications] |
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| Researchers identified the copper transporter CTR1 as the entry receptor for feline leukemia virus subgroup D and genotype I endogenous retrovirus in domestic cats.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators showed that mitochondrial cyclophilin D protected against influenza A virus via disease tolerance.
[Cell Reports] |
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| By combining an unbiased large-scale screening approach with a functional assay, the authors identified TRAIL to be associated with NK cell degranulation against HIV-1-infected target cells.
[EMBO Reports] |
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| Researchers utilized a computational design strategy to produce epitope-optimized, broadly cross-reactive H3 hemagglutinins in order to create a universal H3N2 influenza vaccine.
[NPJ Vaccines] |
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| Scientists summarize key observations of humoral immune responses in people with COVID-19, discuss key features of infection- and vaccine-induced neutralizing antibodies, and consider vaccine designs for inducing antibodies that are broadly protective against different variants of the SARS-CoV-2 virus.
[Nature Immunology] |
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| The authors summarize and discuss the recent discoveries of the physiological roles of virulence factors in V. vulnificus and their regulation by transcription factors in response to various environmental signals.
[Trends in Microbiology] |
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| Investigators review new insights into how commensal microbes that are spatially restricted to the gut lumen can engage in long-distance relationships with innate and adaptive immune cells at systemic sites to fortify host defenses against infections.
[Mucosal Immunology] |
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| Pfizer, Inc. and BioNTech SE announced positive data evaluating the safety, tolerability, and immunogenicity of two Omicron-adapted COVID-19 vaccine candidates: one monovalent and the other bivalent, a combination of the Pfizer-BioNTech COVID-19 Vaccine and a vaccine candidate.
[Pfizer, Inc.] |
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| One of Merck’s next-generation pneumococcal vaccines has sailed through a mid-stage trial and is being readied for a Phase III study in July.
[Fierce Biotech] |
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| FluGen, Inc. announced the dosing of its first subject in a study of older adults ages 65-85 years that will evaluate the safety, tolerability, and immunological response to FluGen’s investigational supra-seasonal, live, single-replication, intranasal M2SR influenza vaccine, and high dose inactivated vaccine.
[FluGen, Inc. (Cision US, Inc.)] |
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| The Coalition for Community and Healthcare Acquired Infection Reduction (CHAIR) selected Dr. Victor Leung as the 2021 CHAIR Leadership Award recipient. Dr. Leung is the Medical Director of Infection Prevention and Control at Providence Health Care in Vancouver, British Columbia, Canada.
[Financial Post] |
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| October 3 – 4, 2022
San Diego, California, United States |
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| | The Pirbright Institute – Surrey, England, United Kingdom |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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