 | | Vol. 10.36 – 14 September, 2022 |
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| Scientists used genome-scale CRISPR screens to identify lysosomal enzyme trafficking factor (LYSET) as essential for infection by cathepsin-dependent viruses including SARS-CoV-2.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The N proteins of highly pathogenic human coronaviruses were found to bind MASP-2, resulting in excessive complement activation by potentiating MBL-dependent MASP-2 activation, and the deposition of MASP-2, C4b, activated C3, and C5b-9.
[Signal Transduction and Targeted Therapy] |
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| In patients with severe COVID-19, lung macrophages expressed a robust inflammatory signature, which correlated with persistent IFN-I signaling at the single-cell level.
[Science Immunology] |
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| The authors investigated HLA-A*24:02-restricted CD8+ T cells specific for SARS-CoV-2-derived spike epitopes in individuals immunized with the BNT162b2 mRNA vaccine.
[Nature Communications] |
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| Impaired response to COVID-19 vaccination is of particular concern in immunosuppressed patients. To determine the best vaccination strategy for this vulnerable group, researchers performed a single center, 1:1 randomized blinded clinical trial.
[Nature Communications] |
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| Investigators employed super-resolution imaging of cultured mammalian cells to show that hydroxychloroquine directly perturbed clustering of ACE2 receptor with both endocytic lipids and PIP2 clusters.
[Communications Biology] |
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| Researchers performed serological, neutralization, and T cell assays among 100 hospital workers aged 22–73 years who received the COVID-19 vaccine.
[Scientific Reports] |
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| The authors investigated whether the human gut microbiota and metabolic function correlated with the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) vaccine response.
[Cell Reports Medicine] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists demonstrated that the formation of a small C. neoformans morphotype — called “seed” cells due to their colonizing ability — was critical for extrapulmonary organ entry.
[Cell Host & Microbe] |
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| Using murine leukemia virus, investigators found that some commensal bacteria promoted the development of leukemia induced by this retrovirus.
[Cell Reports] |
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| Researchers profiled the staphylococcal and C. acnes landscape across four different skin sites of 30 individuals using amplicon-based next-generation sequencing.
[Communications Biology] |
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| The author discusses the virology of Lassa virus, the clinical course of Lassa fever, and the progress towards developing medical countermeasures.
[Nature Reviews Microbiology] |
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| Scientists present what is known about distinct states of immunologic vulnerability to SARS-CoV-2 and how this information can be harnessed to improve prevention and treatment strategies for immunologically high-risk populations.
[Immunity] |
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| Tetra Bio-Pharma, Inc. announced that they signed an agreement with Cellvera Global Holdings LLC for the co-development of ARDS-003 as a combination product with Qifenda 400MG, a commercial-stage broad-spectrum antiviral drug.
[Tetra Bio-Pharma, Inc.] |
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| Dynavax Technologies Corporation announced that the first participant has been dosed in a Phase II clinical trial evaluating the immunogenicity, safety, and tolerability of the JPEO-CBRND’s Recombinant Plague vaccine combined with Dynavax’s CpG 1018® adjuvant, in adults 18 to 55 years of age.
[Dynavax Technologies Corporation] |
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| Cidara Therapeutics, Inc. announced the initiation of its Phase IIa trial to evaluate the pre-exposure prophylactic activity of CD388 against influenza virus.
[Cidara Therapeutics, Inc.] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | Louisiana State University – Baton Rouge, Louisiana, United States |
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| | Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States |
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| | Rutgers New Jersey Medical School – Rutgers, New Jersey, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Boston University – Boston, Massachusetts, United States |
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