 | | Vol. 10.09 – 15 March, 2024 |
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| Co-culture of intestinal organoids with a colibactin-producing polyketide synthase E. coli strain revealed mutational signatures also found in colorectal cancer.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Based on the over-expression of P2Y14R in the intestinal epithelium of mice with experimental colitis, investigators reported that male mice lacking P2Y14R in intestinal epithelial cells exhibited less intestinal injury induced by dextran sulfate sodium.
[Nature Communications] |
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| Researchers engineered a dual endogenous reporter system by genome-editing the SOX9 and KRT20 loci of human colorectal cancer cell lines to express fluorescent reporters, broadcasting aberrant stem cell-like and differentiation activity, respectively.
[Nature Communications] |
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| The authors used transcriptomic analysis along with in vitro and in vivo models of RAS/RAF wild-type colorectal cancer to study YAP1 Ser397 phosphorylation as a potential biomarker for cetuximab resistance.
[British Journal Of Cancer] |
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| Leukemia inhibitory factor-treated gastric cancer cell lines, patient-derived xenograft cells and/or cancer stem cell tumorspheres underwent transcriptomics, laser microdissection-associated proteomics, 2D and 3D invasion assays and in vivo xenograft in mice blood circulation.
[Cell Death Discovery] |
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| Researchers explored the role of solute carrier family 26 member 9 (SLC26A9) in colorectal cancer (CRC) and its related mechanisms through clinical samples from CRC patients, CRC cell lines and mouse models.
[Cell Death Discovery] |
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| Scientists assessed the prognosis of colorectal cancer based on early growth response 4 (EGR4) using the Kaplan-Meier plotter tool and tissue microarray.
[Cancer Gene Therapy] |
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| The authors highlight reported examples of direct, protein-coded isoform variation of ubiquitination enzymes influencing cancer development and progression in gastrointestinal malignancies.
[Cell Death & Disease] |
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| Researchers at the University of Strathclyde have been awarded £2.6 million to develop a preclinical lead drug candidate targeted at advanced prostate and colorectal cancers.
[University of Strathclyde] |
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| Johnson & Johnson announced the submission of a supplemental Biologics License Application to the US FDA seeking approval of TREMFYA® for treatment of adults with moderately to severely active ulcerative colitis.
[Johnson & Johnson] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | University of Montpellier – Montpellier, France |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University of Groningen – Groningen, Netherlands |
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| | Augusta University – Augusta, Georgia, United States |
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