 | | Vol. 10.18 – 24 May, 2024 |
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| Investigators showed that SOX13 boosted protein remodeling of electron transport chain complexes by directly transactivating SCAF1. This led to increased supercomplex assembly, mitochondrial respiration, mitochondrial energetics and chemo- and immune-resistance.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that deficiency of Lgr4 in intestinal epithelium decreased the proportion of enterocytes selective for long-chain fatty acid absorption, leading to reduction in lipid absorption and subsequent improvement in lipid and glucose metabolism.
[Nature Communications] |
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| Researchers developed and validated a pathomics-driven ensemble model for predicting the response to immune checkpoint inhibitors in gastric cancer, using H&E-stained whole slide images.
[Journal Of Immunotherapy of Cancer] |
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| Investigators reported that inhibition of RAF1 suppressed the activation of both wild-type KIT and primary KIT mutations in gastrointestinal stromal tumor, with primary KIT mutations showing greater sensitivity.
[Oncogene] |
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| Scientists reported that the oncogenic factor nucleoporin 43 (NUP43) impacted the process of programmed cell death-ligand 1 (PD-L1) nuclear translocation by regulating the expression level of the PD-L1 chaperone protein Importin 5.
[Cell Death Discovery] |
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| Researchers explored the upstream transcription factors responsible for elevating prostaglandin-endoperoxide synthase 2 (PTGS2) expression in coloretal cancer (CRC) cells. PTGS2 silencing repressed cell growth, migration and invasion in CRC cells.
[Scientific Reports] |
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| The authors review current challenge in inflammatory bowel disease drug discovery, and examine how advances in machine learning and tissue engineering could be used at the preclinical stage where attrition rates are high.
[Nature Reviews Drug Discovery] |
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| The Vrije Universiteit Brussel (VUB) has been awarded a €2.5 million grant to further research FLASH radiation. This new technique means that a cancer patient needs to be treated with radiation only once, instead of dozens of time. The research will first be offered to people with skin cancer, rectal cancer and sarcomas.
[UZ Brussel-VUB] |
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| July 6 – 10, 2024
Copenhagen, Denmark |
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| | University of California, Riverside – Riverside, California, United States |
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| | University Health Network – Toronto, Ontario, Canada |
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| | CRUK Scotland Institute – Glasgow, Scotland, United Kingdom |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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