 | | Vol. 10.30 – 20 September, 2024 |
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| In the NICHE-3 study, a total of 59 patients with locally advanced mismatch repair deficiency colorectal cancer were treated with two four-weekly cycles of nivolumab plus relatlimab before surgery. Results showed that neoadjuvant nivolumab/relatlimab induced high rates of pathologic responses.
[Nature Medicine] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| The authors deciphered the potential function of Fusobacterium nucleatum in modulating anti-PD-1 monoclonal antibody immunotherapy response in microsatellite stable colorectal cancer and its underlying molecular mechanisms.
[Cancer Cell] |
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| TNF-like cytokine 1A (TL1A) and death-domain receptor 3 (DR3) were expressed by cellular subsets with important roles for the initiation and maintenance of intestinal inflammation, serving as potent universal costimulators of effector immune responses, indicating their participation in the pathogenesis of IBD.
[Gut] |
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| Psen1 expression was regulated in experimental gut inflammation and in patients with IBD. On a molecular level, intestinal epithelial cells lacking Psen showed impaired Notch signaling and dysregulated epithelial differentiation.
[Gut] |
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| Researchers developed a rodent injury model where, through luminal delivery, demonstrated that fragmented human intestinal organoids engrafted, proliferated, and persisted throughout the bowel following repair.
[Cell Stem Cell] |
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| Scientists investigated the function and molecular mechanism of glucosidase I (GCS1) in regulating endoplasmic reticulum stress (ER) in colorectal cancer (CRC). GCS1 stimulated CRC growth and migration and reduced ER stress-mediated apoptosis via USP10-mediated deubiquitination of GRP78.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors showed that the kinase activity of doublecortin-like kinase 1 (DCLK1) orchestrated cancer cell–intrinsic and–extrinsic processes that led to pro-invasive and pro-metastatic reprogramming of gastric cancer cells.
[Science Signaling] |
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| Investigators showed that DDX21 was a direct transcriptional target gene of β-catenin and mediated the protumorigenic function of β-catenin in colorectal cancer (CRC). Loss of DDX21 led to cytoplasmic translocation and suppressed the proliferation and migration of CRC cells.
[Oncogene] |
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| Through analyses of chromatin accessibility and gene expression in intestinal progenitor cells during aging, researchers discovered changes of chromatin accessibility and gene expression that had a propensity to exhaust intestinal stem cells.
[iScience] |
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| Scientists summarize recent advances in identifying novel clinical biomarkers, diagnostics, treatment targets, and emerging therapeutics in ulcerative colitis.
[Trends in Pharmacological Sciences] |
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| The authors discuss the use of patient-derived organoids in validation and optimization of multi-drug combinations for personalized treatment strategies in colorectal cancer.
[Journal of Experimental & Clinical Cancer Research] |
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| Investigators provide an overview of the pathophysiological mechanisms underlying IBD and summarize recent advancements in microenvironmental stimulus-responsive nanocarriers for IBD therapy.
[Acta Biomaterialia] |
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| A University of Chicago (UChicago) Medicine patient became the first in the world to receive the drug guselkumab since its approval by the FDA for treating moderate to severe ulcerative colitis.
[UChicago Medicine] |
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| Alamos Gold, Inc. announced a contribution to The Princess Margaret Cancer Foundation to create the new Alamos Gold Chair in Gastrointestinal Surgical Oncology. The $2 million contribution will support the new Chair in making an impact on gastrointestinal cancer research.
[Alamos Gold, Inc. (GlobeNewswire, Inc.)] |
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| October 23-25, 2024
Barcelona, Spain |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Westlake University – Zhejiang, China |
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| | University of Würzburg – Würzburg, Germany |
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| | City of Hope – Monrovia, California, United States |
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