Intestinal Cell News Volume 11.02 | Feb 14 2025

February 14, 2025

2025-02-14 | ICN 11.02

Intestinal Cell News by STEMCELL Technologies

Vol. 11.02 – 14 February, 2025

TOP STORY

HMGA1 Acts as an Epigenetic Gatekeeper of ASCL2 and Wnt Signaling during Colon Tumorigenesis

Researchers established high mobility group A (HMGA1) as an epigenetic gatekeeper of Wnt signals and cell state under conditions of Adenomatous polyposis coli inactivation, illuminating HMGA1 as a potential therapeutic target in colon cancer.
[Journal of Clinical Investigation]

Full Article Graphical Abstract

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PUBLICATIONSListed by the impact factor of the journal

ROS-Induced Cytosolic Release of Mitochondrial PGAM5 Promotes Colorectal Cancer Progression by Interacting with MST3

Investigators showed that upon sensing excessive mitochondrial reactive oxygen species, phosphatase phosphoglycerate mutase 5 (PGAM5), which normally localizes to the mitochondria, underwent aberrant cleavage by presenilin-associated rhomboid-like protein, becoming released into the cytoplasm.
[Nature Communications]

Full Article

PRMT5 Maintains Homeostasis of the Intestinal Epithelium by Modulating Cell Proliferation and Survival

Conditional knockout of protein arginine methyltransferases 5 (Prmt5) in the mouse intestinal epithelium led to a reduction in stem cell population, suppression of cell proliferation, and increased cell apoptosis within the intestinal crypts, accompanied with shortened gut length, and eventual animal mortality.
[Advanced Science]

Full Article

Akkermansia muciniphila Identified as Key Strain to Alleviate Gut Barrier Injury through Wnt Signaling Pathway

Researchers showed that fecal microbiota transplantation regulated gut microbiota and enhanced the protection of antibiotic-induced microbiome-disordered piglets against Escherichia coli K88 challenge, as demonstrated by reduced intestinal pathogen colonization and alleviated gut barrier injury.

[eLife]

Full Article

Single-Cell and Spatial-Resolved Profiling Reveals Cancer-Associated Fibroblast Heterogeneity in Colorectal Cancer Metabolic Subtypes

Investigators identified and described the potential protumor biological properties of secreted frizzled related protein 2 cancer-associated fibroblasts, and agmatinase may be a valuable target for disrupting their properties.

[Journal of Translational Medicine]

Full Article

Oxidative Stress Caused by 3-Monochloro-1,2-Propanediol Provokes Intestinal Stem Cell Hyperproliferation and the Protective Role of Quercetin

Scientists revealed that exposure to 3-monochloropropane-1,2-diol led to a decrease in the number of enterocyte cells and an elevation in apoptosis levels, ultimately disrupting the intestinal epithelial barrier and its function.

[Ecotoxicology and Environmental Safety]

Full Article Graphical Abstract

Odoribacter splanchnicus-Derived Extracellular Vesicles Alleviate Inflammatory Bowel Disease by Modulating Gastrointestinal Inflammation and Intestinal Barrier Function via the NLRP3 Inflammasome Suppression

Researchers indicated that Odoribacter splanchnicus-extracellular vesicles (EVs) effectively ameliorated IBD through repressing NLRP3, strongly supporting the potential of probiotic-derived EVs for alleviating IBD.
[Molecular Medicine]

Full Article

Decoupling Chemical and Mechanical Signaling in Colorectal Cancer Cell Migration

Scientists deconvoluted the chemical from mechanical signaling in the case of the colon cancer cell line HCT-116 and cancer-associated fibroblasts (CAFs). They examined three chemoattractants which allegedly were secreted by CAFs and induced HCT-116 cell migration.
[Scientific Reports]

Full Article

Grow Intestinal Organoids from hPSCs With STEMdiff™ Intestinal Organoid Kit

REVIEWS

TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review

The authors review the role of TL1A in inflammatory bowel disease, evaluate the efficacy of anti-TL1A therapies in clinical trials, and discuss future directions for research and treatment.
[BioDrugs]

Abstract

INDUSTRY AND POLICY NEWS

Local Student Wins $5,000 Scholarship from Crohn’s and Colitis Canada

Wynne Fitzpatrick, a Vanderhoof, BC student from the College of New Caledonia has won a $5,000 national scholarship from Crohn’s and Colitis Canada.
[Caledonia Courier]

Press Release

FEATURED EVENT

Intestinal Cell News Volume 11.02 | Feb 14 2025

HMGA1 Acts as an Epigenetic Gatekeeper of ASCL2 and Wnt Signaling during Colon Tumorigenesis

ROS-Induced Cytosolic Release of Mitochondrial PGAM5 Promotes Colorectal Cancer Progression by Interacting with MST3

PRMT5 Maintains Homeostasis of the Intestinal Epithelium by Modulating Cell Proliferation and Survival

Akkermansia muciniphila Identified as Key Strain to Alleviate Gut Barrier Injury through Wnt Signaling Pathway

Single-Cell and Spatial-Resolved Profiling Reveals Cancer-Associated Fibroblast Heterogeneity in Colorectal Cancer Metabolic Subtypes

Oxidative Stress Caused by 3-Monochloro-1,2-Propanediol Provokes Intestinal Stem Cell Hyperproliferation and the Protective Role of Quercetin

Odoribacter splanchnicus-Derived Extracellular Vesicles Alleviate Inflammatory Bowel Disease by Modulating Gastrointestinal Inflammation and Intestinal Barrier Function via the NLRP3 Inflammasome Suppression

Decoupling Chemical and Mechanical Signaling in Colorectal Cancer Cell Migration

TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review

Local Student Wins $5,000 Scholarship from Crohn’s and Colitis Canada

Advanced Therapies UK

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Postdoctoral Position – Glycobiology of the Intestinal Mucosal

Clinical Faculty – Pediatric Gastroenterology

Research Associate – Epithelial Stem Cell Biology

Postdoctoral Fellow – Cellular Processes and Cancer

Postdoctoral Research Scientist – Computational Biology Group

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