 | | Vol. 6.21 – 10 June, 2022 |
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| Scientists reported that PCDHB14 was inactivated by aberrant methylation of its promoter in HCC patients and that PCDHB14 functioned as a tumor suppressor to promote cell cycle arrest, inhibit cell proliferation, and induce ferroptosis.
[Oncogene] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that loss- and gain-of-function studies confirmed that low expression of GBA1 promoted metastasis of liver cancer both in vitro and in vivo.
[Cell Death & Disease] |
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| Researchers investigated the functional outcome of regulating hyaluronan synthase 2 (HAS2) expression in three murine models: CCl4-induced acute liver injury, CCl4-induced chronic liver fibrosis, and bile duct ligation-induced liver fibrosis.
[Experimental and Molecular Medicine] |
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| Investigators reported that stable knockdown of integrin α6 (ITGA6) with different ITGA6 shRNA expression lentivectors significantly inhibited proliferation, migration, and anchorage-independent growth of HCC cell lines in vitro, and xenograft tumor growth in vitro.
[International Journal of Cancer] |
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| Researchers investigated the role of Dectin-1 in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Condition media generated from Dectin-1 deficient macrophages failed to cause hepatocyte lipid accumulation and hepatic stellate activation.
[Acta Pharmacologica Sinica] |
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Scientists discovered that exosomal Gremlin-1 derived from cancer-associated fibroblasts (CAFs) contributes to epithelial-mesenchymal transition of hepatoma cells.
[Molecular Carcinogenesis] |
| | Investigators developed a diethylnitrosamine-induced liver cancer model in rats to examine hepatocarcinogenesis, and delivered liposomal capsaicin through the subcutaneous transposition of the spleen to the liver.
[Cancer Medicine] |
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| The authors reported that the miR-138-5p mimic or inhibitor decreased or increased, respectively, tube formation capacity in HepG2 and Hep3B cells.
[Journal of Immunology Research] |
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| Researchers reported that over-expression or knock-down miR-27a-3p could significantly affect the proliferation ability of HCCLM3 and Huh-7.
[Chemical Biology & Drug Design] |
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| The authors discuss the latest advances in cell identity conversion during liver regeneration, including conversions between hepatocytes and cholangiocytes and hepatocyte reprogramming to liver progenitor-like cells.
[Current Opinion in Genetics & Development] |
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| Scientists report recent studies on organoids to model human liver diseases and discuss the advantages and limitations of current liver organoids for translational applications.
[Archives of Pharmacal Research] |
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| Arbutus Biopharma Corporation and Vaccitech plc announced the first patient dosed in a Phase IIa clinical trial for the treatment of patients with virologically-suppressed chronic Hepatitis B virus infection.
[Arbutus Biopharma Corporation] |
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| November 10 – 12, 2022
Bordeaux, France |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | La Jolla Institute for Immunology – La Jolla, California, United States |
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| | Norwegian University of Science and Technology -Trondheim, Norway |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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Cancer Stem Cell News
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