 | | Vol. 7.03 – 29 January, 2021 |
| |
|
|
| Scientists investigated the in vivo role of DEAD-box Helicase 15 (Dhx15) in intestinal antibacterial responses by generating mice that were intestinal epithelial cell-specific deficient for Dhx15.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers applied chromosome conformation capture combined with chromatin immunoprecipitation and sequencing to measure enhancer-promoter interactions in progenitor and differentiated cells of the intestinal epithelium.
[Cell Reports] |
|
|
|
| Paneth cell-specific knockout of Cdk5rap3 caused partial loss of Paneth cells, while inducible acute deletion of Cdk5rap3 resulted in disassembly of the rough endoplasmic reticulum and abnormal zymogen granules in the mature Paneth cells, as well as loss of Paneth cells.
[Cell Death & Disease] |
|
|
|
| Investigators found that pumilio-1 (PUM1) mRNA expression was high in primary and metastatic colon cancer cell lines when compared to the normal colon cell line.
[International Journal of Biological Macromolecules] |
|
|
|
| α‐Defensin 5 (DEFA5) directly bound with BMI‐1, which subsequently decreased its binding at the CDKN2a locus and upregulated the expression of two cyclin‐dependent kinase inhibitors, p16 and p19.
[Cancer Science] |
|
|
|
| Using in vivo and organoid models of intestinal epithelial tumorigenesis, scientists found that Wnt pathway activity controls intestinal epithelial villi and crypt structure, morphological features lost upon adenomatous polyposis coli inactivation.
[Journal of Cell Science] |
|
|
|
| Human intestinal stem cell-derived enteroids did not support virus replication from every human norovirus-positive stool sample, which led the authors to test and optimize new medium conditions, identify characteristics of stool samples that allow replication, and evaluate consistency of replication over time.
[mSphere] |
|
|
|
| Surfactant protein A reduced expression of toll-like receptor 4 (TLR4) and proinflammatory cytokines in normal human intestinal epithelial cells.
[Scientific Reports] |
|
|
|
| Investigators provided the first demonstration that farnesyl dimethyl chromanol inhibited colon cancer stem cell viability, survival, self-renewal, pluripotent transcription factors expression, organoids formation, and Wnt/β-catenin signalling, as evidenced by comparisons with vehicle-treated controls.
[Scientific Reports] |
|
|
|
|
| Researchers emphasize on composite prognostic scores from diverse resources with clinical utility in colorectal cancer.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
|
|
|
|
| Merck announced that the European Commission has approved KEYTRUDA, Merck’s anti-PD-1 therapy, as a monotherapy for the first-line treatment of adult patients with MSI-H or dMMR colorectal cancer.
[Merck & Co., Inc.] |
|
|
|
|
| May 17 – 21, 2021
Virtual |
|
|
|
|
|
| | BioMed X Institute – Heidelberg, Germany |
|
|
|
| | University of Freiburg – Freiburg, Germany |
|
|
|
| | Medical University of Gdańsk – Gdańsk, Poland |
|
|
|
| | Karolinska Institutet – Huddinge, Sweden |
|
|
|
| | Aichi Cancer Center – Nagoya, Japan |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
