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| Investigators showed that Apc-mutant intestinal stem cells (ISCs) functioned as bona fide supercompetitors by secreting WNT antagonists, thereby inducing differentiation of neighbouring wild-type ISCs.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Prostaglandin E2 signaling via the E-type prostanoid receptor 4 (EP4) on intestinal epithelial cells repressed epithelial necroptosis and induced resolution of colitis. EP4 expression correlated with an improved inflammatory bowel disease outcome.
[Nature Cell Biology] |
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| The authors used an inducible model of Braf mutation to direct recombination of the oncogenic Braf V637E allele to the murine intestine. Braf mutation was activated after periods of aging, and tissue was assessed for histological, DNA methylation and gene expression changes thereafter.
[Gut] |
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| Using junctional adhesion molecules (JAM)-A knockdown, re-expression and rescue experiments in cell line monolayers, 3D spheroids, patient-derived organoids and xenotransplants, researchers demonstrated that JAM-A silencing promoted proliferation and migration in 2D and 3D cell models and increased tumor volume and metastases in vivo.
[Cell Death & Differentiation] |
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| Scientists showed that cancer cells used competitive cell interactions to actively eliminate wild-type intestine cells in enteroid monolayers and organoids. This apoptosis-dependent process boosted proliferation of intestinal cancer cells.
[Cell Reports] |
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| Investigators demonstrated that inhibition of a high-fat diet (HFD)-activated fatty acid oxidation program created a therapeutic opportunity to counter the effects of a HFD on intestinal stem cells and intestinal tumorigenesis.
[Cell Reports] |
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| Researchers found that fat mass and obesity-associated (FTO) protein levels, but not RNA levels, were downregulated in colorectal cancer (CRC) tissues. Reduced FTO protein expression was correlated with a high recurrence rate and poor prognosis in resectable CRC patients.
[Oncogene] |
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| A delivery system was designed through layer-by-layer (LbL) encapsulating a single Ligilactobacillus salivarius Li01 (Li01) cell with chitosan and alginate. The LbL Li01 displayed improved viability under simulated gastrointestinal conditions and mucoadhesive function.
[NPJ Biofilms and Microbiomes] |
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| The authors revealed a series of key pathways and hub long non-coding RNAs involved in the malignant transformation of gastrointestinal stromal tumors (GISTs). DNM3OS promoted GIST cell proliferation and mitosis by regulating the expression of GLUT4 and CD36.
[Cell Death & Disease] |
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| Ectopic expression and knockdown experiments indicated that MYBL2 was essential for colorectal cell proliferation, DNA synthesis, and cell cycle progression in an ribonucleotide reductase small subunit M2 (RRM2)-dependent manner.
[Cell Death & Disease] |
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| Gene ontology identified gene enrichment related to cytoskeletal organization and apoptotic signaling processes, suggesting modular involvement in tumor cell survival, migration, and epithelial-mesenchymal transformation.
[iScience] |
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| Scientists demonstrated that membrane vesicles from Lacticaseibacillus rhamnosus JB-1 were endocytosed in a likely clathrin-dependent manner by both mouse and human intestinal epithelial cells (IECs) in vitro and by mouse IECs in vivo.
[Scientific Reports] |
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| Researchers demonstrated a novel finding in which miR-29a, b and c down-regulated SMCT-1 expression in colonic epithelial cells and may have partly explained the differential expression of monocarboxylate transporters along the length of the gastrointestinal tract.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Investigators review the current state of the role of IL-6 cytokines in hepatology and gastroenterology and discuss the progress achieved in translating therapeutics targeting gp130 signaling into clinical practice.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors review recent findings on how adult intestinal stem cells differentiate, interact with their environment, and change during aging.
[Current Opinion in Cell Biology] |
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| Scientists discuss the mechanisms underlying immune checkpoint inhibitor resistance and their potential specific applications of this knowledge towards precision medicine strategies in the management of gastro-oesophageal cancers in clinical practice.
[British Journal of Cancer] |
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| MIMETAS, a developer of organ-on-chip-based disease models, and Roche announced that they have entered into a collaboration to develop human disease models to characterize novel compounds in inflammatory bowel disease and hepatitis B virus infections.
[MIMETAS] |
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| A blood test to help guide the treatment of oesophageal, stomach and bowel cancers will be evaluated in a new Flinders University trial set to get underway. The blood test is currently offered under the brand name COLVERA® in the US as a tool to aid in the detection of cancer relapse after treatment.
[Flinders University] |
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| August 12 – 14, 2021
Busan, South Korea |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | The Hebrew University of Jerusalem – Jerusalem, Israel |
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| | University of Maryland, College Park – College Park, Maryland, United States |
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