Intestinal Cell News Volume 7.34 | Sep 10 2021

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    2021-09-10 | ICN 7.34


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.34 – 10 September, 2021
    TOP STORY

    Autophagy Is Required during High MUC2 Mucin Biosynthesis in Colonic Goblet Cells to Contend Metabolic Stress

    Investigators analyzed the autophagy process in high MUC2-producing human HT29-H and a clone HT29-L silenced for MUC2 expression by lentivirus-mediated shRNA, and wild-type and CRISPR/Cas9 MUC2 knock out LS174T cells.
    [American Journal of Gastrointestinal and Liver Physiology]

    Abstract

    PneumaCult for primary airway epithelial cell culture at the air-liquid interface or as airway organoid.
    PUBLICATIONSRanked by the impact factor of the journal

    Cells of the Human Intestinal Tract Mapped across Space and Time

    Researchers used single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to five anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut.
    [Nature]

    Full Article

    STAT1 Coordinates Intestinal Epithelial Cell Death during Gastrointestinal Infection Upstream of Caspase-8

    Scientists elucidated the contribution of central mechanisms of regulated cell death and upstream regulatory components during gastrointestinal infection.
    [Mucosal Immunology]

    Full Article

    KFP-1, a Novel Calcium-Binding Peptide Isolated from Kefir, Promotes Calcium Influx through TRPV6 Channels

    The authors suggested that KFP-1, a novel calcium-binding peptide, bound extracellular calcium ions and entered Caco-2 and IEC-6 cells, and promoted calcium uptake through TRPV6 calcium channels.
    [Molecular Nutrition & Food Research]

    Abstract

    Cytokeratin 7 Expression as a Predictor of an Unfavorable Prognosis in Colorectal Carcinoma

    Scientists determined the prevalence of cytokeratins 7 (CK7) expression in Colorectal carcinoma (CRC) and its impact on overall survival. They analyzed 300 randomly selected surgically treated CRC cases using paraffin embedded tumor tissue samples and evaluated CK7 and CK20 expression using the tissue microarray method.
    [Scientific Reports]

    Full Article

    RAS Specific Protease Induces Irreversible Growth Arrest via p27 in Several KRAS Mutant Colorectal Cancer Cell Lines

    Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.
    [Scientific Reports]

    Full Article

    Berberine Activates the β-Catenin/TCF4 Signaling Pathway by Down-Regulating miR-106b to Promote GLP-1 Production by Intestinal L Cells

    The mechanism analysis demonstrated that a dose of 100 μM berberine down-regulated the miR-106b expression by elevating the methylation levels of miR-106b in STC-1 cells and miR-106b bound to TCF4 in 293T cells.
    [European Journal of Pharmacology]

    Abstract

    Cucumis sativus Extract Elicits Chloride Secretion by Stimulation of the Intestinal TMEM16A Ion Channel

    The effect of C. sativus fruit extract on intestinal chloride secretion was investigated in human colonic T84 cells, ex vivo mouse intestinal tissue using an Ussing chamber, and the two-electrode voltage-clamp technique to record calcium sensitive TMEM16A chloride currents in Xenopus laevis oocytes.
    [Pharmaceutical Biology]

    Full Article

    RecQ-Like Helicase 4 (RECQL4) Exacerbates Resistance to Oxaliplatin in Colon Adenocarcinoma via Activation of the PI3K/AKT Signaling Pathway

    Researchers found RECQL4 was upregulated in colon adenocarcinoma (COAD), especially in oxaliplatin-resistant COAD tissues and cells.
    [Bioengineered]

    Full Article

    Scientific resources to support your cancer research. Learn More!
    REVIEWS

    TLR4 Signaling in the Development of Colitis-Associated Cancer and Its Possible Interplay with MicroRNA-155

    Considerable attention has been focused on the regulation of TLR4 signaling in the context of colitis-associated tumorigenesis. MicroRNA-155 and TLR4 exhibited a similar dynamic expression change during colitis-associated cancer (CAC) development and shared similar CAC-promoting properties.
    [Cell Communication and Signaling]

    Full ArticleGraphical Abstract

    The Role of Fatty Acids in Crohn’s Disease Pathophysiology – an Overview

    The authors highlight the role of fatty acids in maintenance of intestinal and immune homeostasis and supports the supplementation of fatty acids as a promising adjunctive treatment for Crohn’s disease.
    [Molecular and Cellular Endocrinology]

    Full Article

    INDUSTRY AND POLICY NEWS

    AzurRx BioPharma Activates New Clinical Trial Sites in India for Phase II RESERVOIR Trial Evaluating Niclosamide for the Treatment of COVID-19 Gastrointestinal Infections

    AzurRx BioPharma, Inc. announced the activation of seven new clinical trial sites in India for the ongoing RESERVOIR trial evaluating FW-1022. FW-1022 is a proprietary oral tablet formulation of micronized niclosamide developed for the treatment of COVID-19-related gastrointestinal infections.
    [AzurRx BioPharma, Inc.]

    Press Release

    FEATURED EVENT

    Annual London Stem Cell Network Symposium

    October 19, 2021
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Faculty – Urology, Clinical Pharmacy

    Zhejiang University School of Medicine – Hangzhou, China

    Postdoctoral Fellow – Immune Homeostasis of the Intestinal Tract

    University of North Dakota – Grand Forks, North Dakota, United States

    Faculty Position – Cancer Biology and Signal Transduction

    Purdue University – West Lafayette, Indiana, United States

    Investigator – Host Immunity and Microbiome

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    Scientist – Autoimmune and Inflammatory Diseases

    Amgen – San Francisco, California, United States

    > See All Jobs

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