 | | Vol. 8.12 – 1 April, 2022 |
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| Scientists investigated early infection events using both Trichuris muris infections of mice and murine caecaloids, the first in vitro system for whipworm infection and organoid model for live helminths.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers profiled 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidate the potential origin and regulation of tumor-enriched cell types in colorectal cancer.
[Nature Communications] |
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| To gain novel insights into the downstream signaling pathways of receptor tyrosine kinases specific to diffuse-type gastric cancer (DGC), phosphotyrosine-containing proteins associated with activated fibroblast growth factor receptor 2 were purified through two sequential rounds of immunoprecipitation.
[Oncogene] |
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| Given the link between IBD and colitis-associated cancer, as well as the involvement of other IL-1 family members in intestinal tumorigenesis, scientists investigated whether IL-36 cytokines played a role in the pathogenesis of colon cancer.
[Oncogene] |
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| Serine/threonine/tyrosine interacting protein (STYX) overexpression facilitated the proliferation and migration in gastric cancer cells, whereas STYX knockdown had the opposite effects.
[Cell Death & Disease] |
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| Investigators explored a prognostic model for the estimation of tumor-associated mortality in gastric cancer (GC) patients and revealed the RNA-binding protein RBMS1 as a candidate promoter gene for GC metastasis by analyzing GOBO and oncomine high-throughput sequencing datasets for 408 GC patients.
[Cell Death & Disease] |
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| The authors revealed new roles for aryl-hydrocarbon receptor-interacting protein in regulating proteins associated with cancer and metastasis to induce tumorigenic and metastatic properties in colon cancer cells driving liver metastasis.
[British Journal of Cancer] |
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| 4’,5,7-trihydroxyisoflavone probe was a new chemical probe inhibitor of signal transducer and activator of transcription 1 (STAT1) that reduced stemness and angiogenesis in colorectal cancer.
[Journal of Biomedical Science] |
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| Alcohol dehydrogenase 1C (ADH1C) was identified as a target gene closely associated with the development of CRC by the comprehensive application of transcriptomics, proteomics, metabonomics and in silico analysis.
[Acta Pharmacologica Sinica] |
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| Scientists conducted a phosphoproteomic analysis using paired endoscopic biopsy specimens of pre- and post-treatment tumors (Ts) and non-tumor adjacent tissues (NATs) obtained from 4 HER2-positive gastric cancer patients who received trastuzumab-based treatment and from pre-treatment Ts and NATs of 4 HER2-negative gastric cancer patients.
[Scientific Reports] |
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| Using MRI, researchers determined the correlation between glutamine uptake and the distribution of glutamine transporters, namely ASCT2 and SLC38A2, glutaminase, and cancer stem cell markers, such as CD44 and CD166, in a mouse xenograft model of HT29 human colorectal cancer cells.
[Scientific Reports] |
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| Scientists evaluated the selective inhibition of α-mangostin on cancer stem cell (CSCs) in colorectal cancer and the suppressive effect on 5-fluorouracil-induced CSCs.
[BMC Cancer] |
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| The authors provide new evidence explaining the pathogenesis of necrotizing enterocolitis (NEC), explore new findings indicating that NEC development has origins before birth, and discuss future questions and opportunities for discovery in this field.
[Nature Reviews Gastroenterology & Hepatology] |
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| First Wave BioPharma, Inc. announced the continued enhancement of the intellectual property portfolio governing niclosamide as a treatment for COVID-19-related gastrointestinal infections.
[First Wave BioPharma, Inc.] |
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| May 11 – 15, 2022
Amsterdam, Netherlands |
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| Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| | Princeton University – Princeton, New Jersey, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | University of Southern Denmark – Odense M, Denmark |
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