 | | Vol. 9.06 – 17 February, 2023 |
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| Researchers carried out multilevel proteomic analyses, including proteome, phospho-proteome, and transcription factor activity profiles, of 196 cases covering diffuse-type gastric cancer and intestinal-type gastric cancer in Chinese patients.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists applied elemental imaging to the mapping of chemotherapy (CT) biodistribution after therapy in residual colorectal cancer and achieved a comprehensive analysis of the genetic program induced by oxaliplatin-based CT in the tumor microenvironment.
[Nature Communications] |
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| The authors used ERdj5-knockout mice to investigate the potential roles of ERdj5 in IBD. ERdj5 deficiency caused severe inflammation in mouse colitis models and weakened gut barrier function by increasing NF-κB-mediated inflammation.
[Experimental & Molecular Medicine] |
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| Litchi procyanidins significantly inhibited CT26 colon cancer cells proliferation and metastasis in vivo and in vitro. LPC significantly inhibited CT26 colon cancer cells metastasis through increasing CD8+ cytotoxic T lymphocytes infiltration and decreasing the number of macrophages.
[Cell Death & Disease] |
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| Scientists reported that Gab1 expression was decreased in patients with IBD and inversely correlated with IBD severity.
[JCI Insight] |
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| Researchers examined the role of Atg16l1 in protecting the murine small intestinal epithelium from T cell-mediated damage using the anti-CD3 model of enteropathy.
[Mucosal Immunology] |
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| An oxaliplatin-resistant colorectal cancer cell line was established and lncRNA-Neighboring Enhancer of FOXA2 (NEF) was down-regulated in this resistant cell line.
[Cancer Gene Therapy] |
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| Scientists identified a novel crosstalk between protein kinase C α (PKCα) and transforming growth factor β (TGFβ) signaling. RNA-Seq analysis of non-transformed intestinal crypt-like cells and colorectal cancer cells identified TGFβ receptor 1 as a target of PKCα signaling.
[Journal of Biological Chemistry] |
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| Researchers investigated the possible modulating effect of the Slc11a1 R and S variants in DSS-induced colitis by using low acute inflammatory responses (AIRmin) mice homozygous for Slc11a1 R (AIRminRR) or S (AIRminSS) alleles.
[Genes And Immunity] |
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| The authors summarize the mechanisms by which altered copper status causes colorectal cancer (CRC) progression and emphasize the potential of regulating copper status in treating CRC.
[Clinical and Translational Oncology] |
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| The US FDA voted in support of the question of whether data from two proposed single-arm trials will be “sufficient to characterize the benefits and risks” of Jemperli in the curative-intent setting for patients with mismatch repair-deficient/microsatellite instability-high locally advanced rectal cancer.
[GSK plc] |
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| March 6 – 8, 2023
Paris, France |
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| | Luxembourg Institute of Health – Esch-sur-Alzette, Luxembourg |
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| | Vanderbilt-Ingram Cancer Center – Nashville, Tennessee, United States |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | Beckman Research Institute – Monrovia, California, United States |
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| | Imperial College London – London, England, United Kingdom |
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