 | | Vol. 9.28 – 4 August, 2023 |
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| Hollowed nanocarriers with poly-l-lysine coating and mammalian orthoreovirus cell attachment protein σ1 functionalization were explored as functional oral drug delivery vehicles.
[Bioactive Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Inspired from the structure of native intestinal villi, scientists engineered an intestinal organoid chip embedded with engineered artificial microvessels based on co-axial microfluidic technology by using pH-responsive ZIF-8/sodium alginate scaffold.
[Bioactive Materials] |
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| Investigators reported the development of thiol–disulfide hybrid mesoporous organosilica nanoparticles that improved the storage and sustained release of nitric oxide (NO), broadening the therapeutic window of NO-based therapy against colitis.
[Research] |
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| Researchers reported that FERM domain-containing 8 (FRMD8) inhibited cyclin-dependent kinase 4 (CDK4) activation and stabilized retinoblastoma protein, thereby causing cell-cycle arrest and inhibiting colorectal cancer cell growth.
[Cell Reports] |
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| Scientists revealed that 1α,25-dihydroxyvitamin D3, the active metabolite of vitamin D, promoted SIRT1 activation through auto-deacetylation in human colon carcinoma cells, and identified lysine 610 as an essential driver of SIRT1 activity.
[eLife] |
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| Using an intestinal stem cell culture system, investigators cultured colonic cells from normal tissue adjacent to tumor and paired colorectal cancer tissue, as well as cells from healthy tissue.
[Cell Communication And Signaling] |
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| Researchers explored the effect of human plasma alpha-1 antitrypsin protein in the chemically induced mouse model of colorectal cancer.
[BMC Cancer] |
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| Investigators explored the molecular mechanism of circ_0001666 in regulating epithelial–mesenchymal transition -mediated fibrosis in Crohn’s disease in vitro.
[Kaohsiung Journal Of Medical Sciences] |
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| Scientists investigated the probable correlation between cell-free supernatant of Bacillus subtilis and radiation response in normal and cancerous cell lines.
[molecular biology reports] |
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| The authors analyze the evidence for Crohn’s disease as well as ulcerative colitis in order to optimize and ‘personalize’ the choice of therapy, especially in difficult cases.
[Expert Review Of Gastroenterology & Hepatology] |
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| Telavant announced the initiation of the TAHOE study, a Phase II clinical trial of RVT-3101 for the treatment of moderate to severely active Crohn’s disease, with the first patient dosed.
[Telavant] |
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| August 28 – 30, 2023
Santa Fe, New Mexico, United States |
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| | University of Miami – Miami, Florida, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | City of Hope – Monrovia, California, United States |
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