Mammary Cell News Volume 14.17 | May 5 2022

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    Danielle Corrigan
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    2022-05-05 | MCN 14.17


    Mammary Cell News by STEMCELL Technologies
    Vol. 14.17 – 5 May, 2022
    TOP STORY

    OVOL1 Inhibits Breast Cancer Cell Invasion by Enhancing the Degradation of TGF-β Type I Receptor

    Researchers showed that ovo-like transcriptional repressor 1 (OVOL1) was inversely correlated with the epithelial-mesenchymal transition signature, and was an indicator of a favorable prognosis for breast cancer patients.
    [Signal Transduction and Targeted Therapy]

    Full Article

    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    Reduced miR-371b-5p Expression Drives Tumor Progression via CSDE1/RAC1 Regulation in Triple-Negative Breast Cancer

    Scientists identified dysregulated miRNAs in TNBC by profiling miRNA and mRNA expression.
    [Oncogene]

    Full Article

    A Novel HSP90 Inhibitor SL-145 Suppresses Metastatic Triple-Negative Breast Cancer without Triggering the Heat Shock Response

    SL-145 was a novel, rationally-designed C-terminal HSP90 inhibitor that induced apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling.
    [Oncogene]

    Full Article

    Matrix Stiffness Enhances Cancer-Macrophage Interactions and M2-Like Macrophage Accumulation in the Breast Tumor Microenvironment

    The authors applied single-cell RNA sequencing to investigate the differences in the transcriptional landscapes between stiff and compliant MMTV-PyMT mouse mammary tumors.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    CTCF-Induced lncRNA C5orf66-AS1 Facilitates the Progression of Triple-Negative Breast Cancer via Sponging miR-149-5p to Up-Regulate CTCF and CTNNB1 to Activate Wnt/β-Catenin Pathway

    Investigators tested C5orf66-AS1 expression in TNBC cells using qRT-PCR and used functional assays to detect cell behaviors, which showed that C5orf66-AS1 was highly expressed in TNBC cells and that C5orf66-AS1 knockdown attenuated cell proliferation, migration, and invasion while promoting cell apoptosis.
    [American Society for Microbiology]

    Abstract

    HMGA1 Positively Regulates the Microtubule-Destabilizing Protein Stathmin Promoting Motility in TNBC Cells and Decreasing Tumor Sensitivity to Paclitaxel

    Researchers found that the expression of high mobility group A1 (HMGA1) and of the microtubule-destabilizing protein stathmin correlated in breast cancer patients.
    [Cell Death & Disease]

    Full Article

    Lipid Exposure Activates Gene Expression Changes Associated with Estrogen Receptor Negative Breast Cancer

    Utilizing both an in vitro model and samples from women at high risk for estrogen receptor negative breast cancer (ER− BC), the authors showed that lipid exposure engendered gene expression, signaling pathway activation, and histone marks associated with the development of ER− BC.
    [npj Breast Cancer]

    Full Article

    Gold(III)-P-Chirogenic Complex Induce Mitochondrial Dysfunction in Triple-Negative Breast Cancer

    Scientists described AuPhos-19, a small-molecule gold(III)-based agent bearing chiral phosphine ligands that selectively disrupted mitochondrial metabolism in murine and human TNBC cells but not normal epithelial cells.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Polarity Protein SCRIB Interacts with SLC3A2 to Regulate Proliferation and Tamoxifen Resistance in ER+ Breast Cancer

    Researchers showed an unexpected role for the cell polarity protein SCRIB as a tumor-promoter and a regulator of endocrine resistance in estrogen receptor (ER)-positive breast cancer cells.
    [Communications Biology]

    Full Article

    Long Non-Coding RNA MAFG-AS1 Promotes Proliferation and Metastasis of Breast Cancer by Modulating STC2 Pathway

    A long non-coding RNA MAFG-AS1 was explored in detail to understand the significance in the etiology of breast cancer.
    [Cell Death Discovery]

    Full Article

    Growth Factor Dependency in Mammary Organoids Regulates Ductal Morphogenesis during Organ Regeneration

    The authors showed that organoids grown in suspension with minimal concentration of Matrigel and in the presence of a cocktail of growth factors (GFs) regulating EGF and FGF signaling could recapitulate key epithelial layers of adult mammary gland.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Feed-Forward Loops between Metastatic Cancer Cells and Their Microenvironment — the Stage of Escalation

    Scientists summarize how the environment of the most common metastatic sites is influenced by the primary tumor and by the varying dormancy of disseminated tumor cells, with a special focus on how established metastases persist and grow in distant organs due to feed-forward loops.
    [EMBO Molecular Medicine]

    Full Article

    Mesenchymal Stem Cells and Cancer-Associated Fibroblasts as a Therapeutic Strategy for Breast Cancer

    The authors discuss the currently available information regarding the possible use of mesenchymal stromal/stem cells-derived anti-tumor therapies, as well as the utilization of therapies that target cancer-associated fibroblasts in the breast cancer microenvironment.
    [British Journal of Pharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Enhertu Approved in the US for Patients with HER2-Positive Metastatic Breast Cancer Treated with a Prior Anti-HER2-Based Regimen

    AstraZeneca and Daiichi Sankyo’s Enhertu has been approved in the US for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received a prior anti-HER2-based regimen either in the metastatic setting, or in the neoadjuvant or adjuvant setting.
    [AstraZeneca]

    Press Release

    FEATURED EVENT

    Endothelial Cell Phenotypes in Health and Disease

    June 26 – July 1, 2022
    Castelldefels, Spain

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Cancer Research

    Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Cancer Biology

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellow – Cancer Epidemiology and Health Services

    Luxembourg Institute of Health – Strassen, Luxembourg

    Postdoctoral Training Fellow – Functional Genomics

    Institute of Cancer Research – London, England, United Kingdom

    Principal Investigator – Breast Cancer

    Mayo Clinic – Rochester, Minnesota, United States

    > See All Jobs

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